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Investigation of the effects of static magnetic field on apoptosis in bone marrow stem cells of rat

Author

Listed:
  • Zeinab Tavasoli

    (Tarbiat Modares University)

  • Parviz Abdolmaleki

    (Tarbiat Modares University)

  • Seyed Javad Mowla

    (Tarbiat Modares University)

  • Faezeh Ghanati

    (Tarbiat Modares University)

  • Amir Sabet Sarvestani

    (Tarbiat Modares University)

Abstract

This research was carried out to evaluate the influence of static magnetic field on the rate of apoptosis in bone marrow stem cells (BMSCs) of rats. Extracted cells were suspended in αMEM as a culture media for 48 h. After that, cells were exposed to 15 mT static magnetic field (SMF) for 5 h, incessantly with or without FeCl2. The rate of apoptosis was then assessed via flow cytometery. The results showed that either treatment with FeCl2 or exposure to SMF enhanced the rate of apoptotic cells. Moreover, cells that were treated simultaneously with FeCl2 and SMF have higher rate of apoptosis. An increase in apoptosis by 26.5% was induced by SMF alone and an increase in apoptosis by 28.2% was induced by a combination of FeCl2 and SMF, compared to their corresponding controls. The results recommended that the effects of SMF on apoptosis may be related to increment of the number of free radicals in the cells.

Suggested Citation

  • Zeinab Tavasoli & Parviz Abdolmaleki & Seyed Javad Mowla & Faezeh Ghanati & Amir Sabet Sarvestani, 2009. "Investigation of the effects of static magnetic field on apoptosis in bone marrow stem cells of rat," Environment Systems and Decisions, Springer, vol. 29(2), pages 220-224, June.
    • Handle: RePEc:spr:envsyd:v:29:y:2009:i:2:d:10.1007_s10669-008-9210-4
    DOI: 10.1007/s10669-008-9210-4
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    References listed on IDEAS

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    1. Tannishtha Reya & Sean J. Morrison & Michael F. Clarke & Irving L. Weissman, 2001. "Stem cells, cancer, and cancer stem cells," Nature, Nature, vol. 414(6859), pages 105-111, November.
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