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Polypharmacy and the Change of Self-Rated Health in Community-Dwelling Older Adults

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  • Muhammad Helmi Barghouth

    (Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Public Health, Charitéplatz 1, 10117 Berlin, Germany)

  • Elke Schaeffner

    (Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Public Health, Charitéplatz 1, 10117 Berlin, Germany)

  • Natalie Ebert

    (Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Public Health, Charitéplatz 1, 10117 Berlin, Germany)

  • Tim Bothe

    (Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Public Health, Charitéplatz 1, 10117 Berlin, Germany)

  • Alice Schneider

    (Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Univer-sität zu Berlin, Institute of Biometry and Clinical Epidemiology, Charitéplatz 1, 10117 Berlin, Germany)

  • Nina Mielke

    (Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Public Health, Charitéplatz 1, 10117 Berlin, Germany)

Abstract

Polypharmacy is associated with poorer self-rated health (SRH). However, whether polypharmacy has an impact on the SRH progression is unknown. This study investigates the association of polypharmacy with SRH change in 1428 participants of the Berlin Initiative Study aged 70 years and older over four years. Polypharmacy was defined as the intake of ≥5 medications. Descriptive statistics of SRH-change categories stratified by polypharmacy status were reported. The association of polypharmacy with being in SRH change categories was assessed using multinomial regression analysis. At baseline, mean age was 79.1 (6.1) years, 54.0% were females, and prevalence of polypharmacy was 47.1%. Participants with polypharmacy were older and had more comorbidities compared to those without polypharmacy. Over four years, five SRH-change categories were identified. After covariate adjustment, individuals with polypharmacy had higher odds of being in the stable moderate category (OR 3.55; 95% CI [2.43–5.20]), stable low category (OR 3.32; 95% CI [1.65–6.70]), decline category (OR 1.87; 95% CI [1.34–2.62]), and improvement category (OR 2.01; [1.33–3.05]) compared to being in the stable high category independent of the number of comorbidities. Reducing polypharmacy could be an impactful strategy to foster favorable SRH progression in old age.

Suggested Citation

  • Muhammad Helmi Barghouth & Elke Schaeffner & Natalie Ebert & Tim Bothe & Alice Schneider & Nina Mielke, 2023. "Polypharmacy and the Change of Self-Rated Health in Community-Dwelling Older Adults," IJERPH, MDPI, vol. 20(5), pages 1-16, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:5:p:4159-:d:1080708
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    References listed on IDEAS

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    1. Sheung-Tak Cheng & Helene Fung & Alfred Chan, 2007. "Maintaining Self-Rated Health Through Social Comparison in Old Age," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 62(5), pages 277-285.
    2. Jersey Liang & Benjamin A. Shaw & Neal Krause & Joan M. Bennett & Erika Kobayashi & Taro Fukaya & Yoko Sugihara, 2005. "How Does Self-Assessed Health Change With Age? A Study of Older Adults in Japan," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 60(4), pages 224-232.
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