IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i6p3434-d771037.html
   My bibliography  Save this article

Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Author

Listed:
  • Sang-Dol Kim

    (Department of Nursing, College of Health Science, Kangwon National University, Samcheok 25949, Korea)

  • Young-Ran Yeun

    (Department of Nursing, College of Health Science, Kangwon National University, Samcheok 25949, Korea)

Abstract

Chronic low-grade inflammation that accompanies aging is associated with adverse health outcomes and may exacerbate the severity of infectious disease such as COVID-19. Resistance training (RT) has the potential to improve chronic low-grade inflammation, but the evidence remains inconclusive. This study evaluated the effects of RT on chronic low-grade inflammation in elderly adults. MEDLINE, EMBASE, Cochrane Library, CINAHL, RISS, NDSL, and KoreaMed were searched. We included studies that assessed the effect of RT on C-reactive protein (CRP), interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α in those aged ≥60 years. The effect size was estimated using fixed or random-effects models. Subgroup analysis was performed regarding age, health status, training method, number of exercises, intensity, weekly frequency, and duration. In the 18 randomized controlled trials (539 patients) included, RT was effective in alleviating CRP (effect size = −0.72, 95% confidence interval = −1.06 to −0.38, p < 0.001), IL-10 (−3.34, −6.16 to −0.53, p = 0.02), and TNF-α (−0.56, −1.08 to −0.03, p = 0.04) in elderly adults and tended to reduce IL-6 (−0.59, −1.18 to 0.00, p = 0.05). Subgroup analyses showed CRP reduction regardless of age, training method, number of exercises, intensity, weekly frequency, and duration. RT can be used to ameliorate chronic low-grade inflammation in elderly adults.

Suggested Citation

  • Sang-Dol Kim & Young-Ran Yeun, 2022. "Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3434-:d:771037
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/6/3434/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/6/3434/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Camilo Germán Alberto Pérez Chaparro & Philipp Zech & Felipe Schuch & Bernd Wolfarth & Michael Rapp & Andreas Heiβel, 2018. "Effects of aerobic and resistance exercise alone or combined on strength and hormone outcomes for people living with HIV. A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-21, September.
    2. Andrew T. Levin & William P. Hanage & Nana Owusu-Boaitey & Kensington B. Cochran & Seamus P. Walsh & Gideon Meyerowitz-Katz, 2020. "Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-analysis, & Public Policy Implications," NBER Working Papers 27597, National Bureau of Economic Research, Inc.
    3. Denisa Margină & Anca Ungurianu & Carmen Purdel & Dimitris Tsoukalas & Evangelia Sarandi & Maria Thanasoula & Fotios Tekos & Robin Mesnage & Demetrios Kouretas & Aristidis Tsatsakis, 2020. "Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors," IJERPH, MDPI, vol. 17(11), pages 1-27, June.
    4. Paola Gonzalo-Encabo & Gonzalo Maldonado & David Valadés & Carmen Ferragut & Alberto Pérez-López, 2021. "The Role of Exercise Training on Low-Grade Systemic Inflammation in Adults with Overweight and Obesity: A Systematic Review," IJERPH, MDPI, vol. 18(24), pages 1-17, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Haotian Zhao & Zhijian He & Hezhang Yun & Ruifu Wang & Chang Liu, 2022. "A Meta-Analysis of the Effects of Different Exercise Modes on Inflammatory Response in the Elderly," IJERPH, MDPI, vol. 19(16), pages 1-13, August.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Fattahi, Mohammad & Keyvanshokooh, Esmaeil & Kannan, Devika & Govindan, Kannan, 2023. "Resource planning strategies for healthcare systems during a pandemic," European Journal of Operational Research, Elsevier, vol. 304(1), pages 192-206.
    2. Anna Scherbina, 2021. "Assessing the Optimality of a COVID Lockdown in the United States," Economics of Disasters and Climate Change, Springer, vol. 5(2), pages 177-201, July.
    3. Antonio Diez de los Rios, 2022. "A macroeconomic model of an epidemic with silent transmission and endogenous self‐isolation," Canadian Journal of Economics/Revue canadienne d'économique, John Wiley & Sons, vol. 55(S1), pages 581-625, February.
    4. Saskia Morwinsky & Natalie Nitsche & Enrique Acosta, 2021. "COVID-19 fatality in Germany: Demographic determinants of variation in case-fatality rates across and within German federal states during the first and second waves," Demographic Research, Max Planck Institute for Demographic Research, Rostock, Germany, vol. 45(45), pages 1355-1372.
    5. Miguel Casares & Paul Gomme & Hashmat Khan, 2022. "COVID‐19 pandemic and economic scenarios for Ontario," Canadian Journal of Economics/Revue canadienne d'économique, John Wiley & Sons, vol. 55(S1), pages 503-539, February.
    6. Lin Ma & Gil Shapira & Damien de Walque & Quy‐Toan Do & Jed Friedman & Andrei A. Levchenko, 2022. "The Intergenerational Mortality Trade‐Off Of Covid‐19 Lockdown Policies," International Economic Review, Department of Economics, University of Pennsylvania and Osaka University Institute of Social and Economic Research Association, vol. 63(3), pages 1427-1468, August.
    7. Michalski Tomasz & Stępień Joanna, 2021. "Ageing in European post-communist countries – is it a threat to the welfare system?," Environmental & Socio-economic Studies, Sciendo, vol. 9(2), pages 63-71, June.
    8. Tanmay Devi & Kaushik Gopalan, 2022. "A Statistical Model of COVID-19 Infection Incidence in the Southern Indian State of Tamil Nadu," IJERPH, MDPI, vol. 19(17), pages 1-10, September.
    9. Egor Malkov, 2021. "Spousal Occupational Sorting and COVID-19 Incidence: Evidence from the United States," Papers 2107.14350, arXiv.org, revised Sep 2021.
    10. Hilde C. Bjørnland & Malin C. Jensen & Leif Anders Thorsrud, 2023. "Business Cycle and Health Dynamics during the COVID-19 Pandemic. A Scandinavian Perspective," Working Papers No 15/2023, Centre for Applied Macro- and Petroleum economics (CAMP), BI Norwegian Business School.
    11. Jan Krzysztof Solarz & Krzysztof Waliszewski, 2020. "Holistic Framework for COVID-19 Pandemic as Systemic Risk," European Research Studies Journal, European Research Studies Journal, vol. 0(Special 2), pages 340-351.
    12. Ferdinand von Siemens, 2021. "Motivated Beliefs and the Elderly's Compliance With Covid-19 Measures," CESifo Working Paper Series 8832, CESifo.
    13. Andrew Perrault & Marie Charpignon & Jonathan Gruber & Milind Tambe & Maimuna Majumder, 2020. "Designing Efficient Contact Tracing Through Risk-Based Quarantining," NBER Working Papers 28135, National Bureau of Economic Research, Inc.
    14. Xin-Min Qin & Ji-Young Park & Bo-Ram Kim & Chang-Hwa Joo, 2022. "The Effects of Exercise on Acute Immune Responses in Relative Leisure-Deprived People Living with HIV/AIDS: A Pilot Study," IJERPH, MDPI, vol. 19(13), pages 1-13, July.
    15. Quang Dang Nguyen & Mikhail Prokopenko, 2022. "A general framework for optimising cost-effectiveness of pandemic response under partial intervention measures," Papers 2205.08996, arXiv.org, revised Nov 2022.
    16. Christina Bohk-Ewald & Enrique Acosta & Timothy Riffe & Christian Dudel & Mikko Myrskylä, 2021. "Magnitude, global variation, and temporal development of the COVID-19 infection fatality burden," MPIDR Working Papers WP-2021-024, Max Planck Institute for Demographic Research, Rostock, Germany.
    17. Kordonis, Ioannis & Lagos, Athanasios-Rafail & Papavassilopoulos, George P., 2022. "Nash social distancing games with equity constraints: How inequality aversion affects the spread of epidemics," Applied Mathematics and Computation, Elsevier, vol. 434(C).
    18. Cristina Mennitti & Annaluisa Ranieri & Ersilia Nigro & Lorella Tripodi & Mariarita Brancaccio & Jacopo Ulisse & Luca Gentile & Fabio Fimiani & Arturo Cesaro & Giovanni D’Alicandro & Giuseppe Limongel, 2022. "The Impact of Physical Exercise on Obesity in a Cohort of Southern Italian Obese Children: Improvement in Cardiovascular Risk and Immune System Biomarkers," IJERPH, MDPI, vol. 20(1), pages 1-14, December.
    19. Sameena Parveen & Yaser Ali Alhazmi, 2022. "Impact of Intermittent Fasting on Metabolic Syndrome and Periodontal Disease—A Suggested Preventive Strategy to Reduce the Public Health Burden," IJERPH, MDPI, vol. 19(21), pages 1-24, November.
    20. Claudius Gros & Thomas Czypionka & Daniel Gros, 2021. "When to end a lock down? How fast must vaccination campaigns proceed in order to keep health costs in check?," Papers 2103.15544, arXiv.org, revised Jan 2022.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3434-:d:771037. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.