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Prenatal Exposure to Traffic-Related Air Pollution and the DNA Methylation in Cord Blood Cells: MOCEH Study

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  • Jaehyun Park

    (Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Korea
    These authors contributed equally to this work.)

  • Woo Jin Kim

    (Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon 24341, Korea
    These authors contributed equally to this work.)

  • Jeeyoung Kim

    (Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon 24341, Korea)

  • Chan-Yeong Jeong

    (Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon 24341, Korea)

  • Hyesook Park

    (Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul 07804, Korea
    Graduate Program in System Health Science and Engineering (BK21 Plus Program), Ewha Womans University, Seoul 07804, Korea)

  • Yun-Chul Hong

    (Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 03080, Korea)

  • Mina Ha

    (Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan 31114, Korea)

  • Yangho Kim

    (Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Korea)

  • Sungho Won

    (Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, Seoul 08826, Korea
    Department of Public Health Sciences, Seoul National University, Seoul 08826, Korea
    Institute of Health and Environment, Seoul National University, Seoul 08826, Korea
    RexSoft Inc., Seoul 08826, Korea)

  • Eunhee Ha

    (Graduate Program in System Health Science and Engineering (BK21 Plus Program), Ewha Womans University, Seoul 07804, Korea
    Department of Occupational and Environmental Medicine, College of Medicine, Ewha Womans University, Seoul 07804, Korea
    Ewha Medical Research Institute, College of Medicine, Ewha Womans University, Seoul 07804, Korea)

Abstract

Particulate matter with a diameter of ≤10 µm (PM 10 ) and nitrogen dioxide (NO 2 ) affect the DNA methylation in the fetus, but epigenetic studies regarding prenatal exposure to air pollution in Asia are lacking. Therefore, this study aimed to assess whether there is any association between the ambient concentrations of PM 10 and NO 2 and CpG methylation in the cord blood DNA by using a Korean birth cohort. The concentrations of the air pollutants were incorporated into the final LUR model by using the maternal address data. The methylation level was determined using HumanMethylationEPIC BeadChip and a linear regression analysis model. A multipollutant model including both PM 10 and NO 2 and models with single pollutants were used for each trimester exposure. The number of differentially methylated positions was the largest for midpregnancy exposure in both the single pollutant models and the multipollutant regression analysis. Additionally, gene-set analysis regarding midpregnancy exposure revealed four gene ontology terms (cellular response to staurosporine, positive regulation of cytoskeleton organization, neurotransmitter transport, and execution phase of apoptosis). In conclusion, these findings show an association between prenatal PM 10 and NO 2 exposure and DNA methylation in several CpG sites in cord blood cells, especially for midpregnancy exposure.

Suggested Citation

  • Jaehyun Park & Woo Jin Kim & Jeeyoung Kim & Chan-Yeong Jeong & Hyesook Park & Yun-Chul Hong & Mina Ha & Yangho Kim & Sungho Won & Eunhee Ha, 2022. "Prenatal Exposure to Traffic-Related Air Pollution and the DNA Methylation in Cord Blood Cells: MOCEH Study," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3292-:d:768598
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    References listed on IDEAS

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    1. Bryan N Howie & Peter Donnelly & Jonathan Marchini, 2009. "A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies," PLOS Genetics, Public Library of Science, vol. 5(6), pages 1-15, June.
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    Cited by:

    1. Leen Rasking & Céline Roelens & Ben Sprangers & Bernard Thienpont & Tim S. Nawrot & Katrien De Vusser, 2022. "Lupus, DNA Methylation, and Air Pollution: A Malicious Triad," IJERPH, MDPI, vol. 19(22), pages 1-24, November.

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