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A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS)

Author

Listed:
  • Chuan Gao
  • Nan Wang
  • Xiuqing Guo
  • Julie T Ziegler
  • Kent D Taylor
  • Anny H Xiang
  • Yang Hai
  • Steven J Kridel
  • Jerry L Nadler
  • Fouad Kandeel
  • Leslie J Raffel
  • Yii-Der I Chen
  • Jill M Norris
  • Jerome I Rotter
  • Richard M Watanabe
  • Lynne E Wagenknecht
  • Donald W Bowden
  • Elizabeth K Speliotes
  • Mark O Goodarzi
  • Carl D Langefeld
  • Nicholette D Palmer

Abstract

Obesity is growing epidemic affecting 35% of adults in the United States. Previous genome-wide association studies (GWAS) have identified numerous loci associated with obesity. However, the majority of studies have been completed in Caucasians focusing on total body measures of adiposity. Here we report the results from genome-wide and exome chip association studies focusing on total body measures of adiposity including body mass index (BMI), percent body fat (PBF) and measures of fat deposition including waist circumference (WAIST), waist-hip ratio (WHR), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) in Hispanic Americans (nmax = 1263) from the Insulin Resistance Atherosclerosis Family Study (IRASFS). Five SNPs from two novel loci attained genome-wide significance (P

Suggested Citation

  • Chuan Gao & Nan Wang & Xiuqing Guo & Julie T Ziegler & Kent D Taylor & Anny H Xiang & Yang Hai & Steven J Kridel & Jerry L Nadler & Fouad Kandeel & Leslie J Raffel & Yii-Der I Chen & Jill M Norris & J, 2015. "A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS)," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-17, November.
    • Handle: RePEc:plo:pone00:0134649
    DOI: 10.1371/journal.pone.0134649
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    2. Bryan N Howie & Peter Donnelly & Jonathan Marchini, 2009. "A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies," PLOS Genetics, Public Library of Science, vol. 5(6), pages 1-15, June.
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