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Amikacin Therapy in Japanese Pediatric Patients: Narrative Review

Author

Listed:
  • Hideo Kato

    (Department of Pharmacy, Mie University Hospital, Tsu 514-8507, Japan
    Department of Clinical Pharmaceutics, Division of Clinical Medical Science, Mie University Graduate School of Medicine, Tsu 514-8507, Japan)

  • Yukihiro Hamada

    (Department of Pharmacy, Tokyo Women’s Medical University Hospital, Tokyo 162-8666, Japan)

Abstract

Children show a very wide range of physical development processes. These changes impact pharmacokinetic (PK) variability in pediatric patients. Most PK studies have been conducted on the Caucasian population. Therefore, whether current evidence of how developmental change affects PK and exposure-response relationships applies to Japanese pediatric patients remains unclear. This narrative review focuses on amikacin therapy in Japanese pediatric patients and shows the relationship between amikacin concentrations and efficacy/toxicity. Ten relevant articles were identified. Of these, nine articles were published in the 1980s. All studies reported a maximum concentration (Cmax) and minimum concentration (Cmin) of amikacin. Overall, articles reporting PK/pharmacodynamic (PD) indices and minimum inhibitory concentration (MIC) of isolated bacteria in Japanese pediatric patients is lacking, whereas all patients recovered from an infection state and showed negative cultures. Five of the included studies reported the association between Cmin and toxicity. The Cmin in three of four patients who developed toxicity was above 10 mg/L. This narrative review shows that further PK study of amikacin in Japanese pediatric patients is necessary. In particular, the pursuit of knowledge of Cmax/MIC ratio is vital. On the other hand, this review demonstrates that the optimal Cmin for Japanese pediatric patients is below 10 mg/L as a candidate concentration. However, it is noted that the number of patients who developed toxicity is very small.

Suggested Citation

  • Hideo Kato & Yukihiro Hamada, 2022. "Amikacin Therapy in Japanese Pediatric Patients: Narrative Review," IJERPH, MDPI, vol. 19(4), pages 1-10, February.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:4:p:1972-:d:745952
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    1. Atanu Sengupta & Sanjoy De, 2020. "Review of Literature," India Studies in Business and Economics, in: Assessing Performance of Banks in India Fifty Years After Nationalization, chapter 0, pages 15-30, Springer.
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