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Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy)

Author

Listed:
  • Fabrizio Minichilli

    (Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56123 Pisa, Italy
    These authors contributed equally to this work.)

  • Francesca Gorini

    (Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56123 Pisa, Italy
    These authors contributed equally to this work.)

  • Giovanni De Filippis

    (Local Health Authority ASL Lecce, Via Miglietta 5, 73100 Lecce, Italy)

  • Elisa Bustaffa

    (Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56123 Pisa, Italy)

  • Anna Maria Raho

    (Local Health Authority ASL Lecce, Via Miglietta 5, 73100 Lecce, Italy)

  • Anna Melcarne

    (Local Health Authority ASL Lecce, Via Miglietta 5, 73100 Lecce, Italy)

  • Fabrizio Quarta

    (Local Health Authority ASL Lecce, Via Miglietta 5, 73100 Lecce, Italy)

  • Giuseppe Maggiore

    (Local Health Authority ASL Lecce, Via Miglietta 5, 73100 Lecce, Italy)

  • Adele Idolo

    (Local Health Authority ASL Lecce, Via Miglietta 5, 73100 Lecce, Italy)

  • Francesca Serio

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Monteroni 165, 73100 Lecce, Italy)

  • Tiziana Grassi

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Monteroni 165, 73100 Lecce, Italy)

  • Francesco Bagordo

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Monteroni 165, 73100 Lecce, Italy)

  • Idelberto Francesco Castorini

    (Local Health Authority ASL Lecce, Via Miglietta 5, 73100 Lecce, Italy)

  • Giovanni Imbriani

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Monteroni 165, 73100 Lecce, Italy)

  • Fabrizio Bianchi

    (Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56123 Pisa, Italy)

  • Prisco Piscitelli

    (Local Health Authority ASL Lecce, Via Miglietta 5, 73100 Lecce, Italy)

Abstract

In the province of Lecce (southern Italy), a higher incidence of lung cancer (LC) among men compared to regional and national data was reported. In a sub-area in the center of the province (cluster area), the incidence and mortality for LC was even higher. PROTOS is a case–control study aimed at investigating possible risk factors for LC in the province area. A total of 442 patients with LC and 1326 controls matched by sex and age living in the province of Lecce for at least 10 years were enrolled and georeferenced; they filled in a questionnaire with their personal information and exposures. For each risk factor, an Odds Ratio adjusted for all the other variables was calculated. The risk of LC increased with excessive use of alcohol in women, for those subjects with a family cancer history, for each increase in pack/year of cigarettes, for men more exposed considering the industrial district in the cluster area, and for those using pesticides in agriculture without wearing personal protective equipment. The higher incidence of adenocarcinoma in both sexes suggests that, in addition to cigarette smoking, concurrent exposures to other environmental, occupational, and life-style factors may play a role in increased cancer risk and should be more deeply explored.

Suggested Citation

  • Fabrizio Minichilli & Francesca Gorini & Giovanni De Filippis & Elisa Bustaffa & Anna Maria Raho & Anna Melcarne & Fabrizio Quarta & Giuseppe Maggiore & Adele Idolo & Francesca Serio & Tiziana Grassi , 2022. "Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy)," IJERPH, MDPI, vol. 19(14), pages 1-22, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:14:p:8775-:d:866200
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    References listed on IDEAS

    as
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