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Micronuclei in Exfoliated Buccal Cells of Children Living in a Cluster Area of Salento (Southern Italy) with a High Incidence of Lung Cancer: The IMP.AIR Study

Author

Listed:
  • Adele Idolo

    (Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy
    These authors contributed equally to this work.)

  • Tiziana Grassi

    (Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy
    These authors contributed equally to this work.)

  • Francesco Bagordo

    (Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy)

  • Alessandra Panico

    (Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy)

  • Mattia De Giorgi

    (Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy)

  • Francesca Serio

    (Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy)

  • Marcello Guido

    (Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy
    Interuniversity Research Centre on Influenza and other Tnsmitted Infections (CIRI-IT), 16132 Genoa, Italy)

  • Prisco Piscitelli

    (Local Health Authority ASL LE, 73100 Lecce, Italy
    Euro Mediterranean Scientific Biomedical Institute, 72100 Brindisi, Italy)

  • Giovanni De Filippis

    (Local Health Authority ASL LE, 73100 Lecce, Italy)

  • Annamaria Raho

    (Local Health Authority ASL LE, 73100 Lecce, Italy)

  • Antonella De Donno

    (Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy)

Abstract

During the years 2014–2016 the University of Salento performed the “Impact of Air Quality on Health of Residents in the Municipalities of Cutrofiano, Galatina, Sogliano Cavour, Soleto and Sternatia” (IMP.AIR) study, an epidemiological-molecular research project aiming to evaluate early DNA damage in children living in an area of Salento with high incidence of lung cancer among the male population. One hundred and twenty-two children aged 6–8 years attending primary school were enrolled and the frequency of micronucleated cells (MNC) in oral mucosa was evaluated. In addition, a questionnaire was administered to parents to obtain information about personal data, anthropometric characteristics and lifestyles (physical activity, food habits, family context) of the children and perform a multivariate analysis to detect any factors associated with MNC occurrence. Data on airborne pollutants detected in the study area were acquired by the Regional Agency for the Environmental Protection. The presence of MNC was highlighted in about 42% of children with a mean MNC frequency of 0.49‰. The frequency of MNC was associated to obesity, consumption of red or processed meat and having a mother who smokes. Moreover, the prevalence of biomarkers was higher than in another area of Salento not included in the cluster area.

Suggested Citation

  • Adele Idolo & Tiziana Grassi & Francesco Bagordo & Alessandra Panico & Mattia De Giorgi & Francesca Serio & Marcello Guido & Prisco Piscitelli & Giovanni De Filippis & Annamaria Raho & Antonella De Do, 2018. "Micronuclei in Exfoliated Buccal Cells of Children Living in a Cluster Area of Salento (Southern Italy) with a High Incidence of Lung Cancer: The IMP.AIR Study," IJERPH, MDPI, vol. 15(8), pages 1-15, August.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:8:p:1659-:d:162005
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    References listed on IDEAS

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    1. Tiziana Grassi & Antonella De Donno & Francesco Bagordo & Francesca Serio & Prisco Piscitelli & Elisabetta Ceretti & Claudia Zani & Gaia C. V. Viola & Milena Villarini & Massimo Moretti & Sara Levorat, 2016. "Socio-Economic and Environmental Factors Associated with Overweight and Obesity in Children Aged 6–8 Years Living in Five Italian Cities (the MAPEC_LIFE Cohort)," IJERPH, MDPI, vol. 13(10), pages 1-11, October.
    2. Pier Paolo Miglietta & Pierluigi Toma & Francesco Paolo Fanizzi & Antonella De Donno & Benedetta Coluccia & Danilo Migoni & Francesco Bagordo & Francesca Serio, 2017. "A Grey Water Footprint Assessment of Groundwater Chemical Pollution: Case Study in Salento (Southern Italy)," Sustainability, MDPI, vol. 9(5), pages 1-10, May.
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    1. Alessandra Panico & Tiziana Grassi & Francesco Bagordo & Adele Idolo & Francesca Serio & Maria Rosaria Tumolo & Mattia De Giorgi & Marcello Guido & Maria Tutino & Antonella De Donno, 2020. "Micronucleus Frequency in Exfoliated Buccal Cells of Children Living in an Industrialized Area of Apulia (Italy)," IJERPH, MDPI, vol. 17(4), pages 1-18, February.
    2. Fabrizio Minichilli & Francesca Gorini & Giovanni De Filippis & Elisa Bustaffa & Anna Maria Raho & Anna Melcarne & Fabrizio Quarta & Giuseppe Maggiore & Adele Idolo & Francesca Serio & Tiziana Grassi , 2022. "Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy)," IJERPH, MDPI, vol. 19(14), pages 1-22, July.

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