IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i5p2261-d505451.html
   My bibliography  Save this article

Association between Urinary Phthalate Metabolite Concentration and Atopic Dermatitis in Korean Adolescents Participating in the Third Korean National Environmental Health Survey, 2015–2017

Author

Listed:
  • Sang-Woo Kim

    (Department of Occupational and Environmental Medicine, Soonchunhyang University Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul 04401, Korea)

  • Jeongho Lee

    (Department of Pediatrics, Soonchunhyang University Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul 04401, Korea)

  • Soon-Chan Kwon

    (Department of Occupational and Environmental Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Korea)

  • June-Hee Lee

    (Department of Occupational and Environmental Medicine, Soonchunhyang University Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul 04401, Korea)

Abstract

Previous studies have highlighted the potential health effects of phthalate exposure, such as atopic dermatitis and asthma. However, evidence supporting the association between phthalate exposure and atopic dermatitis is limited and based on data collected from Western populations. This study aimed to analyze the association between phthalate exposure and atopic dermatitis in Korean adolescents aged 12–17 years using a nationally representative dataset. We conducted a cross-sectional study using a publicly available dataset from the third Korean National Environmental Health Survey ( n = 797). We divided the study participants into four quartiles according to urinary phthalate metabolite concentrations. The odds ratio of having atopic dermatitis was calculated using the first quartile as the reference group in binary logistic regression. We found that in the logistic regression model, both the urinary Mono-(2-ethyl-5-carboxypentyl) phthalate (MECCP; OR: 1.81; CI: 1.01–3.25) and Mono-benzyl phthalate (MBzP; OR: 1.81; CI: 1.01–3.25) concentrations in the highest quartile were positively associated with atopic dermatitis. The atopic dermatitis group had a significantly higher mean urinary MECCP and MBzP concentration. In the future, longitudinal studies involving repeated measurements are warranted to analyze the long-term effects of phthalate.

Suggested Citation

  • Sang-Woo Kim & Jeongho Lee & Soon-Chan Kwon & June-Hee Lee, 2021. "Association between Urinary Phthalate Metabolite Concentration and Atopic Dermatitis in Korean Adolescents Participating in the Third Korean National Environmental Health Survey, 2015–2017," IJERPH, MDPI, vol. 18(5), pages 1-10, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:5:p:2261-:d:505451
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/5/2261/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/5/2261/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Jaakkola, J.J.K. & Parise, H. & Kislitsin, V. & Lebedeva, N.I. & Spengler, J.D., 2004. "Asthma, Wheezing, and Allergies in Russian Schoolchildren in Relation to New Surface Materials in the Home," American Journal of Public Health, American Public Health Association, vol. 94(4), pages 560-562.
    2. Matthias Wormuth & Martin Scheringer & Meret Vollenweider & Konrad Hungerbühler, 2006. "What Are the Sources of Exposure to Eight Frequently Used Phthalic Acid Esters in Europeans?," Risk Analysis, John Wiley & Sons, vol. 26(3), pages 803-824, June.
    3. Jaakkola, J.J.K. & Øie, L. & Nafstad, P. & Botten, G. & Samuelsen, S.O. & Magnus, P., 1999. "Interior surface materials in the home and the development of bronchial obstruction in young children in Oslo, Norway," American Journal of Public Health, American Public Health Association, vol. 89(2), pages 188-192.
    4. Jaakkola, J.J.K. & Verkasalo, P.K. & Jaakkola, N., 2000. "Plastic wall materials in the home and respiratory health in young children," American Journal of Public Health, American Public Health Association, vol. 90(5), pages 797-799.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. W. S. Kwan & D. Nikezic & Vellaisamy A. L. Roy & K. N. Yu, 2020. "Multiple Stressor Effects of Radon and Phthalates in Children: Background Information and Future Research," IJERPH, MDPI, vol. 17(8), pages 1-27, April.
    2. Hyunok Choi & Norbert Schmidbauer & John Spengler & Carl-Gustaf Bornehag, 2010. "Sources of Propylene Glycol and Glycol Ethers in Air at Home," IJERPH, MDPI, vol. 7(12), pages 1-25, December.
    3. Branislav Kolena & Ida Petrovicova & Tomas Pilka & Zuzana Pucherova & Michal Munk & Bohumil Matula & Viera Vankova & Peter Petlus & Zita Jenisova & Zdenka Rozova & Sona Wimmerova & Tomas Trnovec, 2014. "Phthalate Exposure and Health-Related Outcomes in Specific Types of Work Environment," IJERPH, MDPI, vol. 11(6), pages 1-12, May.
    4. Yun-Jung Yang & Taehyen Kim & Yeon-Pyo Hong, 2021. "Urinary Phthalate Levels Associated with the Risk of Nonalcoholic Fatty Liver Disease in Adults: The Korean National Environmental Health Survey (KoNEHS) 2012–2014," IJERPH, MDPI, vol. 18(11), pages 1-9, June.
    5. Jing Zhao & Yukari Nagai & Wei Gao & Tao Shen & Youming Fan, 2023. "The Effects of Interior Materials on the Restorativeness of Home Environments," IJERPH, MDPI, vol. 20(14), pages 1-11, July.
    6. Giovanna Tranfo & Lidia Caporossi & Daniela Pigini & Silvia Capanna & Bruno Papaleo & Enrico Paci, 2018. "Temporal Trends of Urinary Phthalate Concentrations in Two Populations: Effects of REACH Authorization after Five Years," IJERPH, MDPI, vol. 15(9), pages 1-13, September.
    7. Samantha E. Serrano & Catherine J. Karr & Noah S. Seixas & Ruby H. N. Nguyen & Emily S. Barrett & Sarah Janssen & Bruce Redmon & Shanna H. Swan & Sheela Sathyanarayana, 2014. "Dietary Phthalate Exposure in Pregnant Women and the Impact of Consumer Practices," IJERPH, MDPI, vol. 11(6), pages 1-23, June.
    8. Ruihua Dong & Shanzhen Zhao & Han Zhang & Jingsi Chen & Meiru Zhang & Min Wang & Min Wu & Shuguang Li & Bo Chen, 2017. "Sex Differences in the Association of Urinary Concentrations of Phthalates Metabolites with Self-Reported Diabetes and Cardiovascular Diseases in Shanghai Adults," IJERPH, MDPI, vol. 14(6), pages 1-15, June.
    9. Nipuni Nilakshini Wimalasena & Alice Chang-Richards & Kevin I-Kai Wang & Kim N. Dirks, 2021. "Housing Risk Factors Associated with Respiratory Disease: A Systematic Review," IJERPH, MDPI, vol. 18(6), pages 1-24, March.
    10. Mehzabeen Mannan & Sami G. Al-Ghamdi, 2021. "Indoor Air Quality in Buildings: A Comprehensive Review on the Factors Influencing Air Pollution in Residential and Commercial Structure," IJERPH, MDPI, vol. 18(6), pages 1-25, March.
    11. Barend L. van Drooge & Ioar Rivas & Xavier Querol & Jordi Sunyer & Joan O. Grimalt, 2020. "Organic Air Quality Markers of Indoor and Outdoor PM 2.5 Aerosols in Primary Schools from Barcelona," IJERPH, MDPI, vol. 17(10), pages 1-16, May.
    12. Cong Liu & Zhe Liu & John C Little & Yinping Zhang, 2013. "Convenient, Rapid and Accurate Measurement of SVOC Emission Characteristics in Experimental Chambers," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-9, August.
    13. Eun-Jung Yang & Byung-Sun Choi & Yun-Jung Yang, 2022. "Risk of Nonalcoholic Fatty Liver Disease Is Associated with Urinary Phthalate Metabolites Levels in Adults with Subclinical Hypothyroidism: Korean National Environmental Health Survey (KoNEHS) 2012–20," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    14. Sibylle Hildenbrand & Thomas Gabrio & Gerhard Volland, 2019. "Inter-Day Variability of Metabolites of DEHP and DnBP in Human Urine—Comparability of the Results of Longitudinal Studies with a Cross-Sectional Study," IJERPH, MDPI, vol. 16(6), pages 1-15, March.
    15. Te Liu & Yiyang Jia & Liting Zhou & Qi Wang & Di Sun & Jin Xu & Juan Wu & Huaiji Chen & Feng Xu & Lin Ye, 2016. "Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus–Uterus in Pubertal Female Rats," IJERPH, MDPI, vol. 13(11), pages 1-15, November.
    16. Matthias Wormuth & Evangelia Demou & Martin Scheringer & Konrad Hungerbühler, 2007. "Assessments of Direct Human Exposure—The Approach of EU Risk Assessments Compared to Scenario‐Based Risk Assessment," Risk Analysis, John Wiley & Sons, vol. 27(4), pages 979-990, August.
    17. David Trudel & Lea Horowitz & Matthias Wormuth & Martin Scheringer & Ian T. Cousins & Konrad Hungerbühler, 2008. "Estimating Consumer Exposure to PFOS and PFOA," Risk Analysis, John Wiley & Sons, vol. 28(2), pages 251-269, April.
    18. Jiahui Wang & Zefei Xu & Jingyu Yao & Maochao Hu & Yuewen Sun & Cong Dong & Zhongming Bu, 2022. "Identification of Phthalates from Artificial Products in Chinese Kindergarten Classrooms and the Implications for Preschool Children’s Exposure Assessments," IJERPH, MDPI, vol. 19(13), pages 1-12, June.
    19. Jingping Niu & Qingshan Qu & Juansheng Li & Xingrong Liu & Benzhong Zhang & Zhilan Li & Guowu Ding & Yingbiao Sun & Yanrong Shi & Yaxiong Wan & Xiaobin Hu & Lung-Chi Chen & Alan Mendelsohn & Yu Chen &, 2015. "Improving Knowledge about Children’s Environmental Health in Northwest China," IJERPH, MDPI, vol. 13(1), pages 1-10, December.
    20. Liujia Fan & Lixin Wang & Kexin Wang & Fang Liu & Gang Wang, 2022. "Phthalates in Glass Window Films of Chinese University Dormitories and Their Associations with Indoor Decorating Materials and Personal Care Products," IJERPH, MDPI, vol. 19(22), pages 1-12, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:5:p:2261-:d:505451. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.