IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2020i1p119-d468753.html
   My bibliography  Save this article

Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China

Author

Listed:
  • Mengying Wang

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Siyue Wang

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Xiaowen Wang

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Junhui Wu

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Yao Wu

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Zijing Wang

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Jiating Wang

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Tao Wu

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Yonghua Hu

    (Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

Abstract

Background: Carotid intima-media thickness (cIMT) has been associated with an elevated risk of ischemic stroke (IS) in several studies, but the results are inconsistent. We investigated whether the association between cIMT and IS varied across different IS subtypes, and further assessed gene–cIMT interactions’ association with IS risk. Methods: A total of 1048 IS cases (795 large-artery atherosclerosis (LAA) cases, 103 small-vessel occlusion (SVO) cases, and 150 other subtypes) and 2696 IS-free controls across 2179 families were included in the analysis. Self-reported IS cases were confirmed through medical records’ review and head imaging by computed tomography and/or magnetic resonance imaging. The mean values of the common cIMT obtained in bilateral distal and proximal carotid artery segments were used. The genotype information of rs2910164 polymorphism in microRNA-146a (miR-146a) was also collected. Results: We found that cIMT was significantly associated with a higher risk of IS and LAA subtype but not SVO subtype in the multivariate-adjusted models. The odds ratio (OR) and 95% confidence interval (CI) in the highest quartile versus the lowest quartile of cIMT was 2.48 (1.92–3.20) for IS and 2.75 (2.08–3.64) for LAA (both p trend <0.001). The results also showed that there was a significant interaction between cIMT and rs2910164 genotype with the risk of IS ( p interaction = 0.03) and LAA ( p interaction = 0.02). The associations of cIMT with IS and LAA were strengthened among participants carried rs2910164_GG genotype compared with those with rs2910164_CC genotype. Conclusions: Our results indicate that higher cIMT levels were significantly associated with IS and LAA subtype but not SVO subtype, and the relations were modified by rs2910164 polymorphism in miR-146a.

Suggested Citation

  • Mengying Wang & Siyue Wang & Xiaowen Wang & Junhui Wu & Yao Wu & Zijing Wang & Jiating Wang & Tao Wu & Yonghua Hu, 2020. "Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China," IJERPH, MDPI, vol. 18(1), pages 1-11, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:119-:d:468753
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/1/119/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/1/119/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Peter Libby, 2002. "Inflammation in atherosclerosis," Nature, Nature, vol. 420(6917), pages 868-874, December.
    2. Peter Libby & Paul M Ridker & Göran K. Hansson, 2011. "Progress and challenges in translating the biology of atherosclerosis," Nature, Nature, vol. 473(7347), pages 317-325, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Marit Skogstad & Asgeir Mamen & Lars-Kristian Lunde & Bente Ulvestad & Dagfinn Matre & Hans Christian D. Aass & Reidun Øvstebø & Pia Nielsen & Kari N. Samuelsen & Øivind Skare & Per Anton Sirnes, 2019. "Shift Work Including Night Work and Long Working Hours in Industrial Plants Increases the Risk of Atherosclerosis," IJERPH, MDPI, vol. 16(3), pages 1-11, February.
    2. Anne Mette Fisker Hag & Sune Folke Pedersen & Christina Christoffersen & Tina Binderup & Mette Munk Jensen & Jesper Tranekjær Jørgensen & Dorthe Skovgaard & Rasmus Sejersten Ripa & Andreas Kjaer, 2012. "18F-FDG PET Imaging of Murine Atherosclerosis: Association with Gene Expression of Key Molecular Markers," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-9, November.
    3. Abderrahim Nemmar & Deepa Subramaniyan & Badreldin H Ali, 2012. "Protective Effect of Curcumin on Pulmonary and Cardiovascular Effects Induced by Repeated Exposure to Diesel Exhaust Particles in Mice," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-9, June.
    4. Padayachee Trishanta & Khamiakova Tatsiana & Shkedy Ziv & Burzykowski Tomasz & Salo Perttu & Perola Markus, 2019. "A multivariate linear model for investigating the association between gene-module co-expression and a continuous covariate," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 18(2), pages 1-13, April.
    5. Salvatore Santo Signorelli & Elisa Marino & Salvatore Scuto, 2019. "Inflammation and Peripheral Arterial Disease," J, MDPI, vol. 2(2), pages 1-10, April.
    6. Cailan Lindsay Feingold & Abbas Smiley, 2022. "Healthy Sleep Every Day Keeps the Doctor Away," IJERPH, MDPI, vol. 19(17), pages 1-35, August.
    7. Wen Kong & Xun Niu & Tianshu Zeng & Meixia Lu & Lulu Chen, 2015. "Impact of Treatment with Metformin on Adipocytokines in Patients with Polycystic Ovary Syndrome: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-20, October.
    8. Nonanzit Pérez-Hernández & Gilberto Vargas-Alarcón & Rosalinda Posadas-Sánchez & Nancy Martínez-Rodríguez & Carlos Alfonso Tovilla-Zárate & Adrián Asael Rodríguez-Cortés & Oscar Pérez-Méndez & Ruben B, 2016. "PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population," IJERPH, MDPI, vol. 13(8), pages 1-9, August.
    9. Quefeng Li & Sijian Wang & Chiang-Ching Huang & Menggang Yu & Jun Shao, 2014. "Meta-analysis based variable selection for gene expression data," Biometrics, The International Biometric Society, vol. 70(4), pages 872-880, December.
    10. Mouna Achoui & David Appleton & Mahmood Ameen Abdulla & Khalijah Awang & Mustafa Ali Mohd & Mohd Rais Mustafa, 2010. "In Vitro and In Vivo Anti-Inflammatory Activity of 17-O-Acetylacuminolide through the Inhibition of Cytokines, NF-κB Translocation and IKKβ Activity," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-13, December.
    11. Ted R Miller & Geetha M Waehrer & Debora L Oh & Sukhdip Purewal Boparai & Sheila Ohlsson Walker & Sara Silverio Marques & Nadine Burke Harris, 2020. "Adult health burden and costs in California during 2013 associated with prior adverse childhood experiences," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-15, January.
    12. Jinke Tan & Yafeng Wang, 2019. "Social Integration, Social Support, and All-Cause, Cardiovascular Disease and Cause-Specific Mortality: A Prospective Cohort Study," IJERPH, MDPI, vol. 16(9), pages 1-11, April.
    13. Patricia Hernández-López & Miguel A. Martínez & Estefanía Peña & Myriam Cilla, 2023. "Understanding the Parameter Influence on Lesion Growth for a Mechanobiology Model of Atherosclerosis," Mathematics, MDPI, vol. 11(4), pages 1-25, February.
    14. Satoko Hayakawa & Koji Ohashi & Rei Shibata & Ryotaro Takahashi & Naoya Otaka & Hayato Ogawa & Masanori Ito & Noriyoshi Kanemura & Mizuho Hiramatsu-Ito & Nobuo Ikeda & Toyoaki Murohara & Noriyuki Ouch, 2016. "Association of Circulating Follistatin-Like 1 Levels with Inflammatory and Oxidative Stress Markers in Healthy Men," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-8, May.
    15. Murasko, Jason E., 2008. "Male-female differences in the association between socioeconomic status and atherosclerotic risk in adolescents," Social Science & Medicine, Elsevier, vol. 67(11), pages 1889-1897, December.
    16. Jonas Helgertz & Tommy Bengtsson, 2019. "The Long-Lasting Influenza: The Impact of Fetal Stress During the 1918 Influenza Pandemic on Socioeconomic Attainment and Health in Sweden, 1968–2012," Demography, Springer;Population Association of America (PAA), vol. 56(4), pages 1389-1425, August.
    17. Lars-Kristian Lunde & Øivind Skare & Asgeir Mamen & Per Anton Sirnes & Hans C. D. Aass & Reidun Øvstebø & Elisabeth Goffeng & Dagfinn Matre & Pia Nielsen & Hanne Siri Amdahl Heglum & Stine Eriksen Ham, 2020. "Cardiovascular Health Effects of Shift Work with Long Working Hours and Night Shifts: Study Protocol for a Three-Year Prospective Follow-Up Study on Industrial Workers," IJERPH, MDPI, vol. 17(2), pages 1-16, January.
    18. Stephanie D. Ansley & Jeffrey T. Howard, 2021. "Dietary Intake and Elevated C-Reactive Protein Levels in US Military Veterans," IJERPH, MDPI, vol. 18(2), pages 1-15, January.
    19. Liang Zhou & Jianguang Cai & Gang Liu & Yuan Wei & Hui Tang, 2012. "Associations between Interleukin-1 Gene Polymorphisms and Coronary Heart Disease Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-10, September.
    20. Elżbieta Dembowska & Aleksandra Jaroń & Ewa Gabrysz-Trybek & Joanna Bladowska & Grzegorz Trybek, 2022. "Evaluation of Common Factors of Periodontitis and Cardiovascular Disease in Patients with the Acute Coronary Syndrome," IJERPH, MDPI, vol. 19(13), pages 1-14, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:119-:d:468753. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.