IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0140565.html
   My bibliography  Save this article

Impact of Treatment with Metformin on Adipocytokines in Patients with Polycystic Ovary Syndrome: A Meta-Analysis

Author

Listed:
  • Wen Kong
  • Xun Niu
  • Tianshu Zeng
  • Meixia Lu
  • Lulu Chen

Abstract

Background: Metformin is effective for the treatment of polycystic ovary syndrome, but conflicting results regarding its effect on adipocytokine levels (adiponectin, resistin, visfatin, and leptin) in patients with polycystic ovary syndrome receiving metformin treatment have been reported. To provide high-quality evidence about the effect of metformin treatment on adipocytokines in patients with polycystic ovary syndrome, relevant studies that assessed the levels of adipocytokines (adiponectin, resistin, visfatin, and leptin) in patients with polycystic ovary syndrome receiving treatment with metformin administration were reviewed and analyzed. Methods: A literature search was conducted in the SCI, PUBMED, EMBASE, and Elsevier databases, and personal contact was made with the authors. Standard mean differences and 95% confidence intervals were calculated and combined appropriately. To ensure synthesis of the best available evidence, sensitivity analyses were performed. Results: A total of 34 data sets were included in 4 different outcomes, involving 744 women with polycystic ovary syndrome and adipocytokine levels measured both before and after metformin administration. Metformin treatment was associated with significantly elevated serum adiponectin concentrations (standard mean differences [95% confidence interval], −0.43 [−0.75 to −0.11]) and decreased serum leptin concentrations (0.65 [0.26 to 1.04]), whereas no significant difference in resistin level (−0.01 [−0.49 to 0.45]) or visfatin level (−0.04 [−1.55 to 1.46]) was found. Conclusions: Metformin administration was associated with increased serum adiponectin concentrations and decreased serum leptin levels. Further study is needed to elucidate whether this apparent effect decreases the incidence of type 2 diabetes and other metabolic diseases in patients with polycystic ovary syndrome later in life.

Suggested Citation

  • Wen Kong & Xun Niu & Tianshu Zeng & Meixia Lu & Lulu Chen, 2015. "Impact of Treatment with Metformin on Adipocytokines in Patients with Polycystic Ovary Syndrome: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-20, October.
    • Handle: RePEc:plo:pone00:0140565
    DOI: 10.1371/journal.pone.0140565
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140565
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140565&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0140565?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Peter Libby, 2002. "Inflammation in atherosclerosis," Nature, Nature, vol. 420(6917), pages 868-874, December.
    2. Claire M. Steppan & Shannon T. Bailey & Savitha Bhat & Elizabeth J. Brown & Ronadip R. Banerjee & Christopher M. Wright & Hiralben R. Patel & Rexford S. Ahima & Mitchell A. Lazar, 2001. "The hormone resistin links obesity to diabetes," Nature, Nature, vol. 409(6818), pages 307-312, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Marit Skogstad & Asgeir Mamen & Lars-Kristian Lunde & Bente Ulvestad & Dagfinn Matre & Hans Christian D. Aass & Reidun Øvstebø & Pia Nielsen & Kari N. Samuelsen & Øivind Skare & Per Anton Sirnes, 2019. "Shift Work Including Night Work and Long Working Hours in Industrial Plants Increases the Risk of Atherosclerosis," IJERPH, MDPI, vol. 16(3), pages 1-11, February.
    2. Anne Mette Fisker Hag & Sune Folke Pedersen & Christina Christoffersen & Tina Binderup & Mette Munk Jensen & Jesper Tranekjær Jørgensen & Dorthe Skovgaard & Rasmus Sejersten Ripa & Andreas Kjaer, 2012. "18F-FDG PET Imaging of Murine Atherosclerosis: Association with Gene Expression of Key Molecular Markers," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-9, November.
    3. Padayachee Trishanta & Khamiakova Tatsiana & Shkedy Ziv & Burzykowski Tomasz & Salo Perttu & Perola Markus, 2019. "A multivariate linear model for investigating the association between gene-module co-expression and a continuous covariate," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 18(2), pages 1-13, April.
    4. Salvatore Santo Signorelli & Elisa Marino & Salvatore Scuto, 2019. "Inflammation and Peripheral Arterial Disease," J, MDPI, vol. 2(2), pages 1-10, April.
    5. Cailan Lindsay Feingold & Abbas Smiley, 2022. "Healthy Sleep Every Day Keeps the Doctor Away," IJERPH, MDPI, vol. 19(17), pages 1-35, August.
    6. Nonanzit Pérez-Hernández & Gilberto Vargas-Alarcón & Rosalinda Posadas-Sánchez & Nancy Martínez-Rodríguez & Carlos Alfonso Tovilla-Zárate & Adrián Asael Rodríguez-Cortés & Oscar Pérez-Méndez & Ruben B, 2016. "PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population," IJERPH, MDPI, vol. 13(8), pages 1-9, August.
    7. Anna Czajkowska & Jadwiga Ambroszkiewicz & Anna Mróz & Katarzyna Witek & Dariusz Nowicki & Łukasz Małek, 2020. "The Effect of the Ultra-Marathon Run at a Distance of 100 Kilometers on the Concentration of Selected Adipokines in Adult Men," IJERPH, MDPI, vol. 17(12), pages 1-11, June.
    8. Quefeng Li & Sijian Wang & Chiang-Ching Huang & Menggang Yu & Jun Shao, 2014. "Meta-analysis based variable selection for gene expression data," Biometrics, The International Biometric Society, vol. 70(4), pages 872-880, December.
    9. Mouna Achoui & David Appleton & Mahmood Ameen Abdulla & Khalijah Awang & Mustafa Ali Mohd & Mohd Rais Mustafa, 2010. "In Vitro and In Vivo Anti-Inflammatory Activity of 17-O-Acetylacuminolide through the Inhibition of Cytokines, NF-κB Translocation and IKKβ Activity," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-13, December.
    10. Ted R Miller & Geetha M Waehrer & Debora L Oh & Sukhdip Purewal Boparai & Sheila Ohlsson Walker & Sara Silverio Marques & Nadine Burke Harris, 2020. "Adult health burden and costs in California during 2013 associated with prior adverse childhood experiences," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-15, January.
    11. Jinke Tan & Yafeng Wang, 2019. "Social Integration, Social Support, and All-Cause, Cardiovascular Disease and Cause-Specific Mortality: A Prospective Cohort Study," IJERPH, MDPI, vol. 16(9), pages 1-11, April.
    12. Satoko Hayakawa & Koji Ohashi & Rei Shibata & Ryotaro Takahashi & Naoya Otaka & Hayato Ogawa & Masanori Ito & Noriyoshi Kanemura & Mizuho Hiramatsu-Ito & Nobuo Ikeda & Toyoaki Murohara & Noriyuki Ouch, 2016. "Association of Circulating Follistatin-Like 1 Levels with Inflammatory and Oxidative Stress Markers in Healthy Men," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-8, May.
    13. Murasko, Jason E., 2008. "Male-female differences in the association between socioeconomic status and atherosclerotic risk in adolescents," Social Science & Medicine, Elsevier, vol. 67(11), pages 1889-1897, December.
    14. Jonas Helgertz & Tommy Bengtsson, 2019. "The Long-Lasting Influenza: The Impact of Fetal Stress During the 1918 Influenza Pandemic on Socioeconomic Attainment and Health in Sweden, 1968–2012," Demography, Springer;Population Association of America (PAA), vol. 56(4), pages 1389-1425, August.
    15. Anna Lubkowska & Aleksandra Radecka & Iwona Bryczkowska & Iwona Rotter & Maria Laszczyńska & Wioleta Dudzińska, 2015. "Serum Adiponectin and Leptin Concentrations in Relation to Body Fat Distribution, Hematological Indices and Lipid Profile in Humans," IJERPH, MDPI, vol. 12(9), pages 1-21, September.
    16. Lars-Kristian Lunde & Øivind Skare & Asgeir Mamen & Per Anton Sirnes & Hans C. D. Aass & Reidun Øvstebø & Elisabeth Goffeng & Dagfinn Matre & Pia Nielsen & Hanne Siri Amdahl Heglum & Stine Eriksen Ham, 2020. "Cardiovascular Health Effects of Shift Work with Long Working Hours and Night Shifts: Study Protocol for a Three-Year Prospective Follow-Up Study on Industrial Workers," IJERPH, MDPI, vol. 17(2), pages 1-16, January.
    17. Tahereh Raeisi & Hossein Rezaie & Mina Darand & Akram Taheri & Nazila Garousi & Bahman Razi & Leonardo Roever & Reza Mohseni & Shimels Hussien Mohammed & Shahab Alizadeh, 2021. "Circulating resistin and follistatin levels in obese and non-obese women with polycystic ovary syndrome: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(3), pages 1-18, March.
    18. Liang Zhou & Jianguang Cai & Gang Liu & Yuan Wei & Hui Tang, 2012. "Associations between Interleukin-1 Gene Polymorphisms and Coronary Heart Disease Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-10, September.
    19. Elżbieta Dembowska & Aleksandra Jaroń & Ewa Gabrysz-Trybek & Joanna Bladowska & Grzegorz Trybek, 2022. "Evaluation of Common Factors of Periodontitis and Cardiovascular Disease in Patients with the Acute Coronary Syndrome," IJERPH, MDPI, vol. 19(13), pages 1-14, July.
    20. Yun Hwan Kim & Min Ki Jeong & Hyuntae Park & Sang Kab Park, 2021. "Effects of Regular Taekwondo Intervention on Health-Related Physical Fitness, Cardiovascular Disease Risk Factors and Epicardial Adipose Tissue in Elderly Women with Hypertension," IJERPH, MDPI, vol. 18(6), pages 1-14, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0140565. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.