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Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers

Author

Listed:
  • Hsin-Liang Liu

    (Division of Internal Medicine, Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Hung-Yi Chuang

    (Department of Public Health, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    Department of Environmental and Occupational Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan)

  • Chien-Ning Hsu

    (Department of Pharmacy in Kaohsiung Chang Gung Memorial Hospital, and School of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Su-Shin Lee

    (Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

  • Chen-Cheng Yang

    (Department of Environmental and Occupational Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan)

  • Kuan-Ting Liu

    (Division of Internal Medicine, Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
    School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan)

Abstract

Chronic exposure to lead is neurotoxic to the human peripheral sensory system. Variant vitamin D receptor (VDR) genes and polymorphisms of metallothioneins (MTs) are associated with different outcomes following lead toxicity. However, no evidence of a relationship between lead neurotoxicity and polymorphisms has previously been presented. In this study, we investigated the relationship between the polymorphisms of VDR , MT1A , and MT2A genes and lead toxicity following chronic occupational lead exposure. We measured vibration perception thresholds (VPT) and current perception thresholds (CPT) in 181 workers annually for five years. The outcome variables were correlated to the subject’s index of long-term lead exposure. Polymorphisms of VDR , MT1A , and MT2A were defined. The potential confounders, including age, sex, height, smoking, alcohol consumption, and working life span, were also collected and analyzed using linear regression. The regression coefficients of some gene polymorphisms were at least 20 times larger than regression coefficients of time-weighted index of cumulative blood lead (TWICL) measures. All regression coefficients of TWICL increased slightly. MT1A rs11640851 (AA/CC) was associated with a statistically significant difference in all neurological outcomes except hand and foot VPT. MT1A rs8052394 was associated with statistically significant differences in hand and foot CPT 2000 Hz. In MT2A rs10636, those with the C allele showed a greater effect on hand CPT than those with the G allele. Among the VDR gene polymorphisms, the Apa rs7975232 (CC/AA) single nucleotide polymorphism was associated with the greatest difference in hand CPT. MT2A rs28366003 appeared to have a neural protective effect, whereas Apa (rs7975232) of VDR and MT2A rs10636 increased the neurotoxicity as measured by CPT in the hands. MT1A rs8052394 had a protective effect on large myelinated nerves. MT1A rs11640851 was associated with susceptibility to neurotoxicity.

Suggested Citation

  • Hsin-Liang Liu & Hung-Yi Chuang & Chien-Ning Hsu & Su-Shin Lee & Chen-Cheng Yang & Kuan-Ting Liu, 2020. "Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers," IJERPH, MDPI, vol. 17(8), pages 1-12, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2909-:d:349151
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    References listed on IDEAS

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    1. Emmanuel Obeng-Gyasi, 2018. "Hepatobiliary Related Outcomes in US Adults Exposed to Lead," 2018 Stata Conference 81, Stata Users Group.
    2. Pei Jiang & Wen-Ye Zhu & Xin He & Mi-Mi Tang & Rui-Li Dang & Huan-De Li & Ying Xue & Li-Hong Zhang & Yan-Qin Wu & Ling-Juan Cao, 2015. "Association between Vitamin D Receptor Gene Polymorphisms with Childhood Temporal Lobe Epilepsy," IJERPH, MDPI, vol. 12(11), pages 1-10, October.
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