IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v12y2015i11p13913-13922d58045.html
   My bibliography  Save this article

Association between Vitamin D Receptor Gene Polymorphisms with Childhood Temporal Lobe Epilepsy

Author

Listed:
  • Pei Jiang

    (Institute of Clinical Pharmacy and Pharmacology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Department of Pharmacy, Jining First People’s Hospital, Jining 272011, China
    These authors contributed equally to this work.)

  • Wen-Ye Zhu

    (Institute of Clinical Pharmacy and Pharmacology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    These authors contributed equally to this work.)

  • Xin He

    (Institute of Clinical Pharmacy and Pharmacology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    These authors contributed equally to this work.)

  • Mi-Mi Tang

    (Institute of Clinical Pharmacy and Pharmacology, Second Xiangya Hospital, Central South University, Changsha 410011, China)

  • Rui-Li Dang

    (Institute of Clinical Pharmacy and Pharmacology, Second Xiangya Hospital, Central South University, Changsha 410011, China)

  • Huan-De Li

    (Institute of Clinical Pharmacy and Pharmacology, Second Xiangya Hospital, Central South University, Changsha 410011, China)

  • Ying Xue

    (Institute of Clinical Pharmacy and Pharmacology, Second Xiangya Hospital, Central South University, Changsha 410011, China)

  • Li-Hong Zhang

    (Institute of Clinical Pharmacy and Pharmacology, Second Xiangya Hospital, Central South University, Changsha 410011, China)

  • Yan-Qin Wu

    (Institute of Clinical Pharmacy and Pharmacology, Second Xiangya Hospital, Central South University, Changsha 410011, China)

  • Ling-Juan Cao

    (Institute of Clinical Pharmacy and Pharmacology, Second Xiangya Hospital, Central South University, Changsha 410011, China)

Abstract

Vitamin D (VD) is implicated in multiple aspects of human physiology and vitamin D receptor ( VDR ) polymorphisms are associated with a variety of neuropsychiatric disorders. Although VD deficiency is highly prevalent in epilepsy patients and converging evidence indicates a role for VD in the development of epilepsy, no data is available on the possible relationship between epilepsy and genetic variations of VDR . In this study, 150 controls and 82 patients with temporal lobe epilepsy (TLE) were genotyped for five common VDR polymorphisms (Cdx-2, FokI, BsmI, ApaI and TaqI) by the polymerase chain reaction-ligase detection reaction method. Our results revealed that the frequency of FokI AC genotype was significantly higher in the control group than in the patients ( p = 0.003, OR = 0.39, 95% CI = 0.21–0.73), whereas the AA genotype of ApaI SNP was more frequent in patients than in controls ( p = 0.018, OR = 2.92, 95% CI = 1.2–7.1). However, no statistically significant association was found between Cdx-2, BsmI and TaqI polymorphisms and epilepsy. Additionally, in haplotype analysis, we found the haplotype GAT (BsmI/ApaI/TaqI) conferred significantly increased risk for developing TLE ( p = 0.039, OR = 1.62, 95% CI = 1.02–2.56). As far as we know, these results firstly underline the importance of VDR polymorphisms for the genetic susceptibility to epilepsy.

Suggested Citation

  • Pei Jiang & Wen-Ye Zhu & Xin He & Mi-Mi Tang & Rui-Li Dang & Huan-De Li & Ying Xue & Li-Hong Zhang & Yan-Qin Wu & Ling-Juan Cao, 2015. "Association between Vitamin D Receptor Gene Polymorphisms with Childhood Temporal Lobe Epilepsy," IJERPH, MDPI, vol. 12(11), pages 1-10, October.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:11:p:13913-13922:d:58045
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/12/11/13913/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/12/11/13913/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hsin-Liang Liu & Hung-Yi Chuang & Chien-Ning Hsu & Su-Shin Lee & Chen-Cheng Yang & Kuan-Ting Liu, 2020. "Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers," IJERPH, MDPI, vol. 17(8), pages 1-12, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:12:y:2015:i:11:p:13913-13922:d:58045. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.