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In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans

Author

Listed:
  • Lisa Chedik

    (Institut de Recherche en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, Université de Rennes 1, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France)

  • Dominique Mias-Lucquin

    (Institut de Génétique et Développement de Rennes, UMR CNRS 6290, Université de Rennes 1, 35043 Rennes, France)

  • Arnaud Bruyere

    (Institut de Recherche en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, Université de Rennes 1, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France)

  • Olivier Fardel

    (Institut de Recherche en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, Université de Rennes 1, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France
    Pôle Biologie, Centre Hospitalier Universitaire, 2 rue Henri le Guilloux, 35033 Rennes, France)

Abstract

Intestinal absorption and brain permeation constitute key parameters of toxicokinetics for pesticides, conditioning their toxicity, including neurotoxicity. However, they remain poorly characterized in humans. The present study was therefore designed to evaluate human intestine and brain permeation for a large set of pesticides ( n = 338) belonging to various chemical classes, using an in silico graphical BOILED-Egg/SwissADME online method based on lipophilicity and polarity that was initially developed for drugs. A high percentage of the pesticides (81.4%) was predicted to exhibit high intestinal absorption, with a high accuracy (96%), whereas a lower, but substantial, percentage (38.5%) displayed brain permeation. Among the pesticide classes, organochlorines ( n = 30) constitute the class with the lowest percentage of intestine-permeant members (40%), whereas that of the organophosphorus compounds ( n = 99) has the lowest percentage of brain-permeant chemicals (9%). The predictions of the permeations for the pesticides were additionally shown to be significantly associated with various molecular descriptors well-known to discriminate between permeant and non-permeant drugs. Overall, our in silico data suggest that human exposure to pesticides through the oral way is likely to result in an intake of these dietary contaminants for most of them and brain permeation for some of them, thus supporting the idea that they have toxic effects on human health, including neurotoxic effects.

Suggested Citation

  • Lisa Chedik & Dominique Mias-Lucquin & Arnaud Bruyere & Olivier Fardel, 2017. "In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans," IJERPH, MDPI, vol. 14(7), pages 1-17, June.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:7:p:708-:d:103236
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    References listed on IDEAS

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    1. Christos A. Damalas & Ilias G. Eleftherohorinos, 2011. "Pesticide Exposure, Safety Issues, and Risk Assessment Indicators," IJERPH, MDPI, vol. 8(5), pages 1-18, May.
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