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Protective Roles of Sodium Selenite against Aflatoxin B 1 -Induced Apoptosis of Jejunum in Broilers

Author

Listed:
  • Xi Peng

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
    These authors contributed equally to this study.)

  • Shengqiang Zhang

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
    These authors contributed equally to this study.)

  • Jing Fang

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Hengmin Cui

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Zhicai Zuo

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Junliang Deng

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

Abstract

The effects of aflatoxin B 1 (AFB 1 ) exposure and sodium selenite supplementation on cell apoptosis of jejunum in broilers were studied. A total of 240 one-day-old male AA broilers were randomly assigned four dietary treatments containing 0 mg/kg of AFB 1 (control), 0.3 mg/kg AFB 1 (AFB 1 ), 0.4 mg/kg supplement Se (+ Se) and 0.3 mg/kg AFB 1 + 0.4 mg/kg supplement Se (AFB 1 + Se), respectively. Compared with the control broilers, the number of apoptotic cells, the expression of Bax and Caspase-3 mRNA were significantly increased, while the expression of Bcl-2 mRNA and the Bcl-2/Bax ratio were significantly decreased in AFB 1 broilers. The number of apoptotic cells and the expression of Caspase-3 mRNA in AFB 1 + Se broilers were significantly higher than those in the control broilers, but significantly lower than those in AFB 1 broilers. There were no significant changes in the expression of Bax mRNA between AFB 1 + Se and control broilers; the expression of Bcl-2 mRNA and the Bcl-2/Bax ratio in AFB 1 + Se broilers were significantly lower than those in the control broilers, but significantly higher than those in AFB 1 broilers. In conclusion, 0.3 mg/kg AFB 1 in the diet can increase cell apoptosis, decrease Bcl-2 mRNA expression, and increase of Bax and Caspase-3 mRNA expression in broiler’s jejunum. However, supplementation of dietary sodium selenite at the concentration of 0.4 mg/kg Se may ameliorate AFB 1 -induced apoptosis by increasing Bcl-2 mRNA expression, and decreasing Bax and Caspase-3 mRNA expression.

Suggested Citation

  • Xi Peng & Shengqiang Zhang & Jing Fang & Hengmin Cui & Zhicai Zuo & Junliang Deng, 2014. "Protective Roles of Sodium Selenite against Aflatoxin B 1 -Induced Apoptosis of Jejunum in Broilers," IJERPH, MDPI, vol. 11(12), pages 1-14, December.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:12:p:13130-13143:d:43665
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    References listed on IDEAS

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    1. Fengyuan Wang & Gang Shu & Xi Peng & Jing Fang & Kejie Chen & Hengmin Cui & Zhengli Chen & Zhicai Zuo & Junliang Deng & Yi Geng & Weimin Lai, 2013. "Protective Effects of Sodium Selenite against Aflatoxin B 1 -Induced Oxidative Stress and Apoptosis in Broiler Spleen," IJERPH, MDPI, vol. 10(7), pages 1-11, July.
    2. Jianying Huang & Hengmin Cui & Xi Peng & Jing Fang & Zhicai Zuo & Junliang Deng & Bangyuan Wu, 2013. "The Association between Splenocyte Apoptosis and Alterations of Bax, Bcl-2 and Caspase-3 mRNA Expression, and Oxidative Stress Induced by Dietary Nickel Chloride in Broilers," IJERPH, MDPI, vol. 10(12), pages 1-17, December.
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    Cited by:

    1. Na Liang & Fengyuan Wang & Xi Peng & Jing Fang & Hengmin Cui & Zhengli Chen & Weimin Lai & Yi Zhou & Yi Geng, 2015. "Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B 1," IJERPH, MDPI, vol. 12(9), pages 1-13, September.
    2. Xi Peng & Shiping Bai & Xuemei Ding & Keying Zhang, 2017. "Pathological Impairment, Cell Cycle Arrest and Apoptosis of Thymus and Bursa of Fabricius Induced by Aflatoxin-Contaminated Corn in Broilers," IJERPH, MDPI, vol. 14(1), pages 1-11, January.

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