Author
Listed:
- Ali Allam
(Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt)
- Ahmed Abdeen
(Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt
Center of Excellence in Screening of Environmental Contaminants (CESEC), Benha University, Toukh 13736, Egypt)
- Hari Prasad Devkota
(Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan)
- Samar S. Ibrahim
(Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt)
- Gehan Youssef
(Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt)
- Ahmed Soliman
(Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt)
- Mohamed M. Abdel-Daim
(Department of Pharmaceutical Sciences, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia
Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt)
- Khalid J. Alzahrani
(Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia)
- Khaled Shoghy
(Department of Anatomy and Embryology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32897, Egypt)
- Samah F. Ibrahim
(Department of Clinical Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia)
- Mohamed Aboubakr
(Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt)
Abstract
Deltamethrin (DLM) is a synthetic pyrethroid with anti-acaricide and insecticidal properties. It is commonly used in agriculture and veterinary medicine. Humans and animals are exposed to DLM through the ingestion of polluted food and water, resulting in severe health issues. N -acetylcysteine (NAC) is a prodrug of L-cysteine, the precursor to glutathione. It can restore the oxidant-antioxidant balance. Therefore, this research aimed to examine whether NAC may protect broiler chickens against oxidative stress, at the level of biochemical and molecular alterations caused by DLM intoxication. The indicators of liver and kidney injury in the serum of DLM-intoxicated and NAC-treated groups were examined. Furthermore, lipid peroxidation, antioxidant markers, superoxide dismutase activity, and apoptotic gene expressions (caspase-3 and Bcl-2) were investigated. All parameters were significantly altered in the DLM-intoxicated group, suggesting that DLM could induce oxidative damage and apoptosis in hepato-renal tissue. The majority of the changes in the studied parameters were reversed when NAC therapy was used. In conclusion, by virtue of its antioxidant and antiapoptotic properties, NAC enabled the provision of significant protection effects against DLM-induced hepato-renal injury.
Suggested Citation
Ali Allam & Ahmed Abdeen & Hari Prasad Devkota & Samar S. Ibrahim & Gehan Youssef & Ahmed Soliman & Mohamed M. Abdel-Daim & Khalid J. Alzahrani & Khaled Shoghy & Samah F. Ibrahim & Mohamed Aboubakr, 2022.
"N -Acetylcysteine Alleviated the Deltamethrin-Induced Oxidative Cascade and Apoptosis in Liver and Kidney Tissues,"
IJERPH, MDPI, vol. 19(2), pages 1-13, January.
Handle:
RePEc:gam:jijerp:v:19:y:2022:i:2:p:638-:d:719119
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