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Remarkable concordance in associations between epigenetic clocks and health behaviors across three countries

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Listed:
  • Klopack, Eric T.
  • Hernandez, Belinda
  • Potter, Claire
  • Faul, Jessica D.
  • Hill, Claire
  • Smyth, Laura
  • Mitchell, Colter
  • McCrory, Cathal
  • Kenny, Rose Anne
  • McKnight, Amy Jayne
  • McGuinness, Bernadette
  • Crimmins, Eileen M.

Abstract

Research utilizing epigenetic clocks has accelerated in recent years, but it is largely unknown how consistently these measures perform across country and cultural contexts, and thus, how useful they are for understanding the large differences in health outcomes across countries. We assess epigenetic aging in three countries (the US, Ireland, and Northern Ireland) utilizing survey data from each country and evaluated how these measures are associated with three well-studied health behaviors (heavy alcohol use, smoking, and BMI). In general, we found remarkable consistency across these studies, suggesting epigenetic clocks are potentially highly useful for monitoring health and aging processes in different contexts. More research is needed on other health risks and in non-Western and low- and middle-income countries.

Suggested Citation

  • Klopack, Eric T. & Hernandez, Belinda & Potter, Claire & Faul, Jessica D. & Hill, Claire & Smyth, Laura & Mitchell, Colter & McCrory, Cathal & Kenny, Rose Anne & McKnight, Amy Jayne & McGuinness, Bern, 2025. "Remarkable concordance in associations between epigenetic clocks and health behaviors across three countries," Social Science & Medicine, Elsevier, vol. 381(C).
    • Handle: RePEc:eee:socmed:v:381:y:2025:i:c:s0277953625006185
    DOI: 10.1016/j.socscimed.2025.118287
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    References listed on IDEAS

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    1. Martinez, Rae Anne M. & Howard, Annie Green & Fernández-Rhodes, Lindsay & Maselko, Joanna & Pence, Brian W. & Dhingra, Radhika & Galea, Sandro & Uddin, Monica & Wildman, Derek E. & Aiello, Allison E., 2024. "Does biological age mediate the relationship between childhood adversity and depression? Insights from the Detroit Neighborhood Health Study," Social Science & Medicine, Elsevier, vol. 340(C).
    2. Lumley, Thomas, 2004. "Analysis of Complex Survey Samples," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 9(i08).
    3. Phelps, Nowell H & Singleton, Rosie K & Zhou, Bin & Heap, Rachel A & Mishra, Anu & Bennett, James E & Paciorek, Christopher J & Lhoste, Victor PF & Carrillo-Larco, Rodrigo M & Stevens, Gretchen A & Ro, 2024. "Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults," Open Access Publications from Kiel Institute for the World Economy 295105, Kiel Institute for the World Economy.
    4. World Health Organization, 2017. "WHO report on the global tobacco epidemic 2017: Monitoring tobacco use and prevention policies," University of California at San Francisco, Center for Tobacco Control Research and Education qt8nw5p0zt, Center for Tobacco Control Research and Education, UC San Francisco.
    5. Karen Sugden & Terrie E Moffitt & Thalida Em Arpawong & Louise Arseneault & Daniel W Belsky & David L Corcoran & Eileen M Crimmins & Eilis Hannon & Renate Houts & Jonathan S Mill & Richie Poulton & Sa, 2023. "Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 78(8), pages 1375-1385.
    6. Simons, Ronald L. & Ong, Mei Ling & Lei, Man-Kit & Klopach, Eric & Berg, Mark & Zhang, Yue & Philibert, Robert & Gibbons, Frederick X. & Beach, Steven R.H., 2022. "Shifts in lifestyle and socioeconomic circumstances predict change—for better or worse—in speed of epigenetic aging: A study of middle-aged black women," Social Science & Medicine, Elsevier, vol. 307(C).
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