IDEAS home Printed from https://ideas.repec.org/a/eee/phsmap/v516y2019icp280-307.html
   My bibliography  Save this article

Modelling and optimal control of HIV/AIDS prevention through PrEP and limited treatment

Author

Listed:
  • Saha, Sangeeta
  • Samanta, G.P.

Abstract

Epidemic outbreak is one of the primary issue that induce behavioural changes in healthy individuals to avoid contracting infection. We here propose a compartmental model for the transmission of HIV/AIDS including treatment and Pre-exposure prophylaxis (PrEP). It accounts for the effect of individual’s behavioural response due to information of PrEP also. Taking PrEP by uninfected individuals actually can prevent the acquisition of HIV infection. Model analysis has been performed as well as the local and global stability of equilibrium points is established. Further, an optimal control problem has been formulated to minimize the cost and disease fatality by choosing the treatment and the effect of information regarding PrEP as control variables. Numerical analysis gives that if only control via information regarding PrEP is used, then it will be economical for early phase of the time period whereas treatment works well for long term control. Moreover, simultaneous use of both the control interventions is more useful than any single applied control policy and it reduces the number of infective individuals and also minimizes the economic cost generated from disease burden and controls. In the model it can be observed how uptake of PrEP can effect in the population by reducing the number of HIV infections. Moreover the combined effect of both the control policies is found to be more economical during the entire epidemic period whereas the implementation of a single policy is comparatively found less economical viable.

Suggested Citation

  • Saha, Sangeeta & Samanta, G.P., 2019. "Modelling and optimal control of HIV/AIDS prevention through PrEP and limited treatment," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 516(C), pages 280-307.
    • Handle: RePEc:eee:phsmap:v:516:y:2019:i:c:p:280-307
    DOI: 10.1016/j.physa.2018.10.033
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0378437118313815
    Download Restriction: Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000
    File URL: https://libkey.io/10.1016/j.physa.2018.10.033?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to

    for a different version of it.

    References listed on IDEAS

    as
    1. Wang, Yi & Cao, Jinde & Jin, Zhen & Zhang, Haifeng & Sun, Gui-Quan, 2013. "Impact of media coverage on epidemic spreading in complex networks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 392(23), pages 5824-5835.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Saha, Sangeeta & Samanta, Guruprasad, 2022. "Analysis of a host–vector dynamics of a dengue disease model with optimal vector control strategy," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 195(C), pages 31-55.
    2. Saha, Sangeeta & Dutta, Protyusha & Samanta, Guruprasad, 2022. "Dynamical behavior of SIRS model incorporating government action and public response in presence of deterministic and fluctuating environments," Chaos, Solitons & Fractals, Elsevier, vol. 164(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Fangzhou Li & Zhiming Feng & Peng Li & Zhen You, 2017. "Measuring directional urban spatial interaction in China: A migration perspective," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-19, January.
    2. Huo, Liang’an & Wang, Li & Song, Guoxiang, 2017. "Global stability of a two-mediums rumor spreading model with media coverage," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 482(C), pages 757-771.
    3. Han, Dun & Sun, Mei & Li, Dandan, 2015. "Epidemic process on activity-driven modular networks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 432(C), pages 354-362.
    4. Wu, Qingchu & Zhou, Rong & Hadzibeganovic, Tarik, 2019. "Conditional quenched mean-field approach for recurrent-state epidemic dynamics in complex networks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 518(C), pages 71-79.
    5. Fadwa El Kihal & Imane Abouelkheir & Mostafa Rachik & Ilias Elmouki, 2019. "Role of Media and Effects of Infodemics and Escapes in the Spatial Spread of Epidemics: A Stochastic Multi-Region Model with Optimal Control Approach," Mathematics, MDPI, vol. 7(3), pages 1-24, March.
    6. Han, Dun & Sun, Mei, 2014. "Can memory and conformism resolve the vaccination dilemma?," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 415(C), pages 95-104.
    7. Greenhalgh, David & Rana, Sourav & Samanta, Sudip & Sardar, Tridip & Bhattacharya, Sabyasachi & Chattopadhyay, Joydev, 2015. "Awareness programs control infectious disease – Multiple delay induced mathematical model," Applied Mathematics and Computation, Elsevier, vol. 251(C), pages 539-563.
    8. Javier Cifuentes-Faura & Ursula Faura-Martínez & Matilde Lafuente-Lechuga, 2022. "Mathematical Modeling and the Use of Network Models as Epidemiological Tools," Mathematics, MDPI, vol. 10(18), pages 1-14, September.
    9. Chang, Xinghua & Wang, Jianrong & Liu, Maoxing & Yan, Xue, 2025. "An SIS infectious disease model with nonlinear incidence and disease awareness on complex networks," Chaos, Solitons & Fractals, Elsevier, vol. 196(C).
    10. Huo, Liang’an & Wang, Li & Zhao, Xiaomin, 2019. "Stability analysis and optimal control of a rumor spreading model with media report," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 517(C), pages 551-562.
    11. Yao Hongxing & Zou Yushi, 2019. "Research on Rumor Spreading Model with Time Delay and Control Effect," Journal of Systems Science and Information, De Gruyter, vol. 7(4), pages 373-389, August.
    12. Zhang, Zizhen & Rahman, Ghaus ur & Gómez-Aguilar, J.F. & Torres-Jiménez, J., 2022. "Dynamical aspects of a delayed epidemic model with subdivision of susceptible population and control strategies," Chaos, Solitons & Fractals, Elsevier, vol. 160(C).
    13. Du, Yuxian & Gao, Cai & Hu, Yong & Mahadevan, Sankaran & Deng, Yong, 2014. "A new method of identifying influential nodes in complex networks based on TOPSIS," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 399(C), pages 57-69.
    14. Han, Dun & Sun, Mei & Li, Dandan, 2015. "The virus variation model by considering the degree-dependent spreading rate," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 433(C), pages 42-50.

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:phsmap:v:516:y:2019:i:c:p:280-307. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.journals.elsevier.com/physica-a-statistical-mechpplications/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.