IDEAS home Printed from https://ideas.repec.org/a/eee/jmvana/v187y2022ics0047259x21001056.html
   My bibliography  Save this article

Consistent estimation of a joint model for multivariate longitudinal and survival data with latent variables

Author

Listed:
  • Kang, Kai
  • Song, Xinyuan

Abstract

The investigation of the relationship between a time-to-event outcome and time-dependent risk factors is often of great interest in longitudinal studies. However, the time-dependent risk factors may not be directly observed or simply measured by a single variable. Instead, they are latent and should be characterized by several observed variables from different aspects. In this article, we consider a novel joint modeling framework to examine the effects of latent time-dependent risk factors on the hazard of interest. A factor analysis model is used to depict the dependence between time-dependent latent variables and multivariate longitudinal observed variables, and a proportional hazard model is adopted for linking latent time-dependent factors to the hazard of interest. We develop a hybrid procedure that combines an asymptotically distribution-free generalized least square approach and a conditional score method. Theoretical results are provided on the consistency and asymptotic normality of parameter estimators. The method is evaluated through simulation studies and applied to a dataset about Alzheimer’s disease.

Suggested Citation

  • Kang, Kai & Song, Xinyuan, 2022. "Consistent estimation of a joint model for multivariate longitudinal and survival data with latent variables," Journal of Multivariate Analysis, Elsevier, vol. 187(C).
    • Handle: RePEc:eee:jmvana:v:187:y:2022:i:c:s0047259x21001056
    DOI: 10.1016/j.jmva.2021.104827
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0047259X21001056
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.jmva.2021.104827?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Y. K. Tseng & Y. R. Su & M. Mao & J. L. Wang, 2015. "An extended hazard model with longitudinal covariates," Biometrika, Biometrika Trust, vol. 102(1), pages 135-150.
    2. Chen, Chyong-Mei & Shen, Pao-sheng & Tseng, Yi-Kuan, 2018. "Semiparametric transformation joint models for longitudinal covariates and interval-censored failure time," Computational Statistics & Data Analysis, Elsevier, vol. 128(C), pages 116-127.
    3. Erning Li & Naisyin Wang & Nae-Yuh Wang, 2007. "Joint Models for a Primary Endpoint and Multiple Longitudinal Covariate Processes," Biometrics, The International Biometric Society, vol. 63(4), pages 1068-1078, December.
    4. Xiao Song & Marie Davidian & Anastasios A. Tsiatis, 2002. "A Semiparametric Likelihood Approach to Joint Modeling of Longitudinal and Time-to-Event Data," Biometrics, The International Biometric Society, vol. 58(4), pages 742-753, December.
    5. Yeqian Liu & Tao Hu & Jianguo Sun, 2020. "Regression analysis of interval-censored failure time data with cured subgroup and mismeasured covariates," Communications in Statistics - Theory and Methods, Taylor & Francis Journals, vol. 49(1), pages 189-202, January.
    6. Deng Pan & Haijin He & Xinyuan Song & Liuquan Sun, 2015. "Regression Analysis of Additive Hazards Model With Latent Variables," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 110(511), pages 1148-1159, September.
    7. Yi, Fengting & Tang, Niansheng & Sun, Jianguo, 2020. "Regression analysis of interval-censored failure time data with time-dependent covariates," Computational Statistics & Data Analysis, Elsevier, vol. 144(C).
    8. Yi-Kuan Tseng & Fushing Hsieh & Jane-Ling Wang, 2005. "Joint modelling of accelerated failure time and longitudinal data," Biometrika, Biometrika Trust, vol. 92(3), pages 587-603, September.
    9. Molei Liu & Jiehuan Sun & Jose D. Herazo-Maya & Naftali Kaminski & Hongyu Zhao, 2019. "Joint Models for Time-to-Event Data and Longitudinal Biomarkers of High Dimension," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 11(3), pages 614-629, December.
    10. Shuwei Li & Jianguo Sun & Tian Tian & Xia Cui, 2020. "Semiparametric regression analysis of doubly censored failure time data from cohort studies," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 26(2), pages 315-338, April.
    11. Elizabeth R. Brown & Joseph G. Ibrahim & Victor DeGruttola, 2005. "A Flexible B-Spline Model for Multiple Longitudinal Biomarkers and Survival," Biometrics, The International Biometric Society, vol. 61(1), pages 64-73, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Dimitris Rizopoulos, 2011. "Dynamic Predictions and Prospective Accuracy in Joint Models for Longitudinal and Time-to-Event Data," Biometrics, The International Biometric Society, vol. 67(3), pages 819-829, September.
    2. repec:jss:jstsof:35:i09 is not listed on IDEAS
    3. Y. K. Tseng & Y. R. Su & M. Mao & J. L. Wang, 2015. "An extended hazard model with longitudinal covariates," Biometrika, Biometrika Trust, vol. 102(1), pages 135-150.
    4. Jimin Ding & Jane-Ling Wang, 2008. "Modeling Longitudinal Data with Nonparametric Multiplicative Random Effects Jointly with Survival Data," Biometrics, The International Biometric Society, vol. 64(2), pages 546-556, June.
    5. Yi, Fengting & Tang, Niansheng & Sun, Jianguo, 2020. "Regression analysis of interval-censored failure time data with time-dependent covariates," Computational Statistics & Data Analysis, Elsevier, vol. 144(C).
    6. Lisa M. McCrink & Adele H. Marshall & Karen J. Cairns, 2013. "Advances in Joint Modelling: A Review of Recent Developments with Application to the Survival of End Stage Renal Disease Patients," International Statistical Review, International Statistical Institute, vol. 81(2), pages 249-269, August.
    7. Wei Yang & Dawei Xie & Qiang Pan & Harold I. Feldman & Wensheng Guo, 2017. "Joint Modeling of Repeated Measures and Competing Failure Events in a Study of Chronic Kidney Disease," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 9(2), pages 504-524, December.
    8. Hongtu Zhu & Joseph G. Ibrahim & Yueh-Yun Chi & Niansheng Tang, 2012. "Bayesian Influence Measures for Joint Models for Longitudinal and Survival Data," Biometrics, The International Biometric Society, vol. 68(3), pages 954-964, September.
    9. Rizopoulos, Dimitris, 2012. "Fast fitting of joint models for longitudinal and event time data using a pseudo-adaptive Gaussian quadrature rule," Computational Statistics & Data Analysis, Elsevier, vol. 56(3), pages 491-501.
    10. Jaeun Choi & Jianwen Cai & Donglin Zeng, 2017. "Penalized Likelihood Approach for Simultaneous Analysis of Survival Time and Binary Longitudinal Outcome," Sankhya B: The Indian Journal of Statistics, Springer;Indian Statistical Institute, vol. 79(2), pages 190-216, November.
    11. Dimitris Rizopoulos & Geert Verbeke & Emmanuel Lesaffre & Yves Vanrenterghem, 2008. "A Two-Part Joint Model for the Analysis of Survival and Longitudinal Binary Data with Excess Zeros," Biometrics, The International Biometric Society, vol. 64(2), pages 611-619, June.
    12. Robert M. Elashoff & Gang Li & Ning Li, 2008. "A Joint Model for Longitudinal Measurements and Survival Data in the Presence of Multiple Failure Types," Biometrics, The International Biometric Society, vol. 64(3), pages 762-771, September.
    13. Jaeun Choi & Donglin Zeng & Andrew F. Olshan & Jianwen Cai, 2018. "Joint modeling of survival time and longitudinal outcomes with flexible random effects," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(1), pages 126-152, January.
    14. Chen, Chyong-Mei & Shen, Pao-sheng & Tseng, Yi-Kuan, 2018. "Semiparametric transformation joint models for longitudinal covariates and interval-censored failure time," Computational Statistics & Data Analysis, Elsevier, vol. 128(C), pages 116-127.
    15. Atanu B & Gajendra V & Jesna J & Ramesh V, 2017. "Multiple Imputations for Determining an Optimum Biological Dose of a Metronomic Chemotherapy," Biostatistics and Biometrics Open Access Journal, Juniper Publishers Inc., vol. 3(5), pages 129-140, October.
    16. Zhang, Zili & Charalambous, Christiana & Foster, Peter, 2023. "A Gaussian copula joint model for longitudinal and time-to-event data with random effects," Computational Statistics & Data Analysis, Elsevier, vol. 181(C).
    17. Roula Tsonaka & Geert Verbeke & Emmanuel Lesaffre, 2009. "A Semi-Parametric Shared Parameter Model to Handle Nonmonotone Nonignorable Missingness," Biometrics, The International Biometric Society, vol. 65(1), pages 81-87, March.
    18. Tang, Nian-Sheng & Tang, An-Min & Pan, Dong-Dong, 2014. "Semiparametric Bayesian joint models of multivariate longitudinal and survival data," Computational Statistics & Data Analysis, Elsevier, vol. 77(C), pages 113-129.
    19. Yih‐Huei Huang & Wen‐Han Hwang & Fei‐Yin Chen, 2016. "Improving efficiency using the Rao–Blackwell theorem in corrected and conditional score estimation methods for joint models," Biometrics, The International Biometric Society, vol. 72(4), pages 1136-1144, December.
    20. Yangxin Huang & Xiaosun Lu & Jiaqing Chen & Juan Liang & Miriam Zangmeister, 2018. "Joint model-based clustering of nonlinear longitudinal trajectories and associated time-to-event data analysis, linked by latent class membership: with application to AIDS clinical studies," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 24(4), pages 699-718, October.
    21. Samuel Iddi & Geert Molenberghs, 2012. "A joint marginalized multilevel model for longitudinal outcomes," Journal of Applied Statistics, Taylor & Francis Journals, vol. 39(11), pages 2413-2430, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:jmvana:v:187:y:2022:i:c:s0047259x21001056. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/wps/find/journaldescription.cws_home/622892/description#description .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.