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Structure and dynamics of human complication-disease network

Author

Listed:
  • Jiang, Xiong-Fei
  • Xiong, Long
  • Bai, Ling
  • Lin, Jie
  • Zhang, Jing-Feng
  • Yan, Kun
  • Zhu, Jia-Zhen
  • Zheng, Bo
  • Zheng, Jian-Jun

Abstract

A complication is an unanticipated disease arisen following, induced by a disease, a treatment or a procedure. We compile a human disease-complication network from the medical data and investigate the characteristics of the network. It is observed that the modules of the network are dominated by the classes of diseases. The relations between modules are unveiled in detail. Three nontrivial motifs are identified from the network. We further simulate the dynamics of motifs with the Boolean dynamic model. Each motif represents a specific dynamic behavior, which is potentially functional in the disease system, such as generating temporal progressions and governing the responses to fluctuating external stimuli.

Suggested Citation

  • Jiang, Xiong-Fei & Xiong, Long & Bai, Ling & Lin, Jie & Zhang, Jing-Feng & Yan, Kun & Zhu, Jia-Zhen & Zheng, Bo & Zheng, Jian-Jun, 2022. "Structure and dynamics of human complication-disease network," Chaos, Solitons & Fractals, Elsevier, vol. 164(C).
    • Handle: RePEc:eee:chsofr:v:164:y:2022:i:c:s0960077922008141
    DOI: 10.1016/j.chaos.2022.112633
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    References listed on IDEAS

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