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A chaos study of tumor and effector cells in fractional tumor-immune model for cancer treatment

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  • Kumar, Sunil
  • Kumar, Ajay
  • Samet, Bessem
  • Gómez-Aguilar, J.F.
  • Osman, M.S.

Abstract

A tumor is most dangerous disease of medical science which is a mass or lumps of tissue that’s formed by an accumulation of abnormal cells. A famous fractional tumor-immune model is interpreting the dynamics of tumor and effector cells. In this work, we provide a comparative and chaotic study of tumor and effector cells through fractional tumor-immune dynamical model. A new arbitrary operator based on the Mittag-Leffler law is assumed for this study. Again, we examine the interactions among distinct tumor cell inhabitants and immune structure through a model of real world problem of medical science. We First investigate the dynamical effect of the activation of the effector immune and tumor cells by using Adams-Bashforth-Moulton and Toufik-Atangana methods. Furthermore, this paper analyses the existence and uniqueness of given tumor-immune model of arbitrary order. Further, we have examined the dynamical behaviors of the fractional tumor-immunne model and obtained results are compared with exiting results by other methods. Numerical simulations are executed by Adams-Bashforth-Moulton and Toufik-Atangana methods using popular Atangana-Baleanu fractional derivative. Our obtained results will be useful for biologists to the treatment of cancer disease.

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  • Kumar, Sunil & Kumar, Ajay & Samet, Bessem & Gómez-Aguilar, J.F. & Osman, M.S., 2020. "A chaos study of tumor and effector cells in fractional tumor-immune model for cancer treatment," Chaos, Solitons & Fractals, Elsevier, vol. 141(C).
    • Handle: RePEc:eee:chsofr:v:141:y:2020:i:c:s0960077920307177
    DOI: 10.1016/j.chaos.2020.110321
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    7. Liao, Xiaozhong & Ran, Manjie & Yu, Donghui & Lin, Da & Yang, Ruocen, 2022. "Chaos analysis of Buck converter with non-singular fractional derivative," Chaos, Solitons & Fractals, Elsevier, vol. 156(C).
    8. Ahmad, Shabir & Ullah, Aman & Akgül, Ali, 2021. "Investigating the complex behaviour of multi-scroll chaotic system with Caputo fractal-fractional operator," Chaos, Solitons & Fractals, Elsevier, vol. 146(C).
    9. Das, Parthasakha & Das, Samhita & Das, Pritha & Rihan, Fathalla A. & Uzuntarla, Muhammet & Ghosh, Dibakar, 2021. "Optimal control strategy for cancer remission using combinatorial therapy: A mathematical model-based approach," Chaos, Solitons & Fractals, Elsevier, vol. 145(C).

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