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A stochastic delay model of HIV pathogenesis with reactivation of latent reservoirs

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  • Qesmi, Redouane
  • Hammoumi, Aayah

Abstract

In this paper, we propose a stochastic HIV model with latency to describe the factors that are responsible for extinction and persistence of the infection. This model incorporates latent period of reservoirs that inhibits the eradication of the virus. It is shown that this model leads naturally to a stochastic system of differential delay equations. We derived the global existence, positivity and boundedness properties of solutions of the proposed stochastic system. Analyzing the model, sufficient conditions for the eradication and the persistence of the disease are also obtained. Furthermore, numerical simulations are performed to study the impact of several strategies of drug therapy on the persistence and the extinction of HIV virus. Our results constitute an important step towards control strategies to reduce HIV infection.

Suggested Citation

  • Qesmi, Redouane & Hammoumi, Aayah, 2020. "A stochastic delay model of HIV pathogenesis with reactivation of latent reservoirs," Chaos, Solitons & Fractals, Elsevier, vol. 132(C).
    • Handle: RePEc:eee:chsofr:v:132:y:2020:i:c:s096007791930551x
    DOI: 10.1016/j.chaos.2019.109594
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    References listed on IDEAS

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    1. Wang, Yan & Jiang, Daqing & Hayat, Tasawar & Ahmad, Bashir, 2017. "A stochastic HIV infection model with T-cell proliferation and CTL immune response," Applied Mathematics and Computation, Elsevier, vol. 315(C), pages 477-493.
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    3. Yan Wang & Daqing Jiang, 2017. "Stationary Distribution and Extinction of a Stochastic Viral Infection Model," Discrete Dynamics in Nature and Society, Hindawi, vol. 2017, pages 1-13, October.
    4. Huang, Zaitang & Yang, Qigui & Cao, Junfei, 2011. "Complex dynamics in a stochastic internal HIV model," Chaos, Solitons & Fractals, Elsevier, vol. 44(11), pages 954-963.
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    Cited by:

    1. Liu, Qun & Jiang, Daqing, 2020. "Dynamical behavior of a higher order stochastically perturbed HIV/AIDS model with differential infectivity and amelioration," Chaos, Solitons & Fractals, Elsevier, vol. 141(C).

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