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Virus dynamic behavior of a stochastic HIV/AIDS infection model including two kinds of target cell infections and CTL immune responses

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  • Qi, Kai
  • Jiang, Daqing
  • Hayat, Tasawar
  • Alsaedi, Ahmed

Abstract

This study investigated the impact of white noise on the HIV/AIDS model with a cytotoxic T lymphocyte (CTL) immune response. The model introduced the interactions between the virus and two kinds of target cells, CD4+ T cells and macrophages. It was theoretically proved that the solution of the stochastic model is positive and global, as well as the existence of an ergodic stationary distribution. The sufficient conditions were established for viral eradication. By comparing these new results to those of a deterministic model, it is determined that white noise can promote the extinction of the virus. Theoretical results have been verified by numerical simulation of several examples.

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  • Qi, Kai & Jiang, Daqing & Hayat, Tasawar & Alsaedi, Ahmed, 2021. "Virus dynamic behavior of a stochastic HIV/AIDS infection model including two kinds of target cell infections and CTL immune responses," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 188(C), pages 548-570.
    • Handle: RePEc:eee:matcom:v:188:y:2021:i:c:p:548-570
    DOI: 10.1016/j.matcom.2021.05.009
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    References listed on IDEAS

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    Cited by:

    1. Tan, Yiping & Cai, Yongli & Sun, Xiaodan & Wang, Kai & Yao, Ruoxia & Wang, Weiming & Peng, Zhihang, 2022. "A stochastic SICA model for HIV/AIDS transmission," Chaos, Solitons & Fractals, Elsevier, vol. 165(P1).
    2. Shi, Zhenfeng & Jiang, Daqing, 2022. "Dynamical behaviors of a stochastic HTLV-I infection model with general infection form and Ornstein–Uhlenbeck process," Chaos, Solitons & Fractals, Elsevier, vol. 165(P2).
    3. A. M. Elaiw & N. H. AlShamrani & E. Dahy & A. A. Abdellatif & Aeshah A. Raezah, 2023. "Effect of Macrophages and Latent Reservoirs on the Dynamics of HTLV-I and HIV-1 Coinfection," Mathematics, MDPI, vol. 11(3), pages 1-26, January.
    4. Zhou, Baoquan & Jiang, Daqing & Han, Bingtao & Hayat, Tasawar, 2022. "Threshold dynamics and density function of a stochastic epidemic model with media coverage and mean-reverting Ornstein–Uhlenbeck process," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 196(C), pages 15-44.
    5. Elaiw, A.M. & Alsaedi, A.J. & Hobiny, A.D. & Aly, S., 2023. "Stability of a delayed SARS-CoV-2 reactivation model with logistic growth and adaptive immune response," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 616(C).

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