IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v114y2018icp108-118.html
   My bibliography  Save this article

Modeling the dynamics of glioma-immune surveillance

Author

Listed:
  • Khajanchi, Subhas

Abstract

The proposed mathematical model describes how glioma cells evolve and survive the brief encounter with the immune system mediated by macrophages and the tumor specific CD8+T cells. We characterize the dynamics of the system by observing biologically realistic singular points and their stability analysis. The global asymptotic stability of the interior equilibrium point is studied with the help of Lyapunov method and we prove the uniform persistence by using the method of average Lyapunov function. The numerical simulation demonstrates that the model, with the parameter assumptions and values we used, is capable of reproducing glioma escape from immune surveillance in a biologically realistic time frame. We investigate the conditions under which the macrophages can be infiltrated, and identify the parameter values for which the inhibition of the gliomas proliferation is acquired.

Suggested Citation

  • Khajanchi, Subhas, 2018. "Modeling the dynamics of glioma-immune surveillance," Chaos, Solitons & Fractals, Elsevier, vol. 114(C), pages 108-118.
    • Handle: RePEc:eee:chsofr:v:114:y:2018:i:c:p:108-118
    DOI: 10.1016/j.chaos.2018.06.028
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077918305034
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.chaos.2018.06.028?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Álvaro G López & Jesús M Seoane & Miguel A F Sanjuán, 2016. "Decay Dynamics of Tumors," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-15, June.
    2. Khajanchi, Subhas & Ghosh, Dibakar, 2015. "The combined effects of optimal control in cancer remission," Applied Mathematics and Computation, Elsevier, vol. 271(C), pages 375-388.
    3. Khajanchi, Subhas, 2015. "Bifurcation analysis of a delayed mathematical model for tumor growth," Chaos, Solitons & Fractals, Elsevier, vol. 77(C), pages 264-276.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Khajanchi, Subhas & Nieto, Juan J., 2019. "Mathematical modeling of tumor-immune competitive system, considering the role of time delay," Applied Mathematics and Computation, Elsevier, vol. 340(C), pages 180-205.
    2. Das, Dhiraj Kumar & Khajanchi, Subhas & Kar, T.K., 2020. "The impact of the media awareness and optimal strategy on the prevalence of tuberculosis," Applied Mathematics and Computation, Elsevier, vol. 366(C).
    3. Khajanchi, Subhas, 2021. "The impact of immunotherapy on a glioma immune interaction model," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    4. Khajanchi, Subhas & Bera, Sovan & Roy, Tapan Kumar, 2021. "Mathematical analysis of the global dynamics of a HTLV-I infection model, considering the role of cytotoxic T-lymphocytes," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 180(C), pages 354-378.
    5. Li, Qian & Xiao, Yanni, 2019. "Bifurcation analyses and hormetic effects of a discrete-time tumor model," Applied Mathematics and Computation, Elsevier, vol. 363(C), pages 1-1.
    6. Sardar, Mrinmoy & Biswas, Santosh & Khajanchi, Subhas, 2021. "The impact of distributed time delay in a tumor-immune interaction system," Chaos, Solitons & Fractals, Elsevier, vol. 142(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Khajanchi, Subhas, 2021. "The impact of immunotherapy on a glioma immune interaction model," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    2. Sardar, Mrinmoy & Biswas, Santosh & Khajanchi, Subhas, 2021. "The impact of distributed time delay in a tumor-immune interaction system," Chaos, Solitons & Fractals, Elsevier, vol. 142(C).
    3. Khajanchi, Subhas & Nieto, Juan J., 2019. "Mathematical modeling of tumor-immune competitive system, considering the role of time delay," Applied Mathematics and Computation, Elsevier, vol. 340(C), pages 180-205.
    4. Li, Qian & Xiao, Yanni, 2019. "Bifurcation analyses and hormetic effects of a discrete-time tumor model," Applied Mathematics and Computation, Elsevier, vol. 363(C), pages 1-1.
    5. Liu, Xiangdong & Li, Qingze & Pan, Jianxin, 2018. "A deterministic and stochastic model for the system dynamics of tumor–immune responses to chemotherapy," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 500(C), pages 162-176.
    6. Khajanchi, Subhas & Ghosh, Dibakar, 2015. "The combined effects of optimal control in cancer remission," Applied Mathematics and Computation, Elsevier, vol. 271(C), pages 375-388.
    7. Dzyubak, Larysa & Dzyubak, Oleksandr & Awrejcewicz, Jan, 2023. "Nonlinear multiscale diffusion cancer invasion model with memory of states," Chaos, Solitons & Fractals, Elsevier, vol. 168(C).
    8. Bera, Sovan & Khajanchi, Subhas & Roy, Tapan Kumar, 2022. "Dynamics of an HTLV-I infection model with delayed CTLs immune response," Applied Mathematics and Computation, Elsevier, vol. 430(C).
    9. Khajanchi, Subhas & Das, Dhiraj Kumar & Kar, Tapan Kumar, 2018. "Dynamics of tuberculosis transmission with exogenous reinfections and endogenous reactivation," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 497(C), pages 52-71.
    10. Duan, Wei-Long & Lin, Ling, 2021. "Noise and delay enhanced stability in tumor-immune responses to chemotherapy system," Chaos, Solitons & Fractals, Elsevier, vol. 148(C).
    11. Khajanchi, Subhas & Bera, Sovan & Roy, Tapan Kumar, 2021. "Mathematical analysis of the global dynamics of a HTLV-I infection model, considering the role of cytotoxic T-lymphocytes," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 180(C), pages 354-378.
    12. Das, Parthasakha & Das, Samhita & Das, Pritha & Rihan, Fathalla A. & Uzuntarla, Muhammet & Ghosh, Dibakar, 2021. "Optimal control strategy for cancer remission using combinatorial therapy: A mathematical model-based approach," Chaos, Solitons & Fractals, Elsevier, vol. 145(C).
    13. Liu, Yujuan & Lu, Qiong, 2020. "Hopf bifurcations in 3D competitive system with mixing exponential and rational growth rates," Applied Mathematics and Computation, Elsevier, vol. 378(C).
    14. Han, Haoming & Zhang, Jing & Liu, Yan, 2023. "Stability analysis of hybrid high-order nonlinear multiple time-delayed coupled systems via aperiodically intermittent control," Chaos, Solitons & Fractals, Elsevier, vol. 172(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:114:y:2018:i:c:p:108-118. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.