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Bifurcation analysis of a delayed mathematical model for tumor growth

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  • Khajanchi, Subhas

Abstract

In this study, we present a modified mathematical model of tumor growth by introducing discrete time delay in interaction terms. The model describes the interaction between tumor cells, healthy tissue cells (host cells) and immune effector cells. The goal of this study is to obtain a better compatibility with reality for which we introduced the discrete time delay in the interaction between tumor cells and host cells. We investigate the local stability of the non-negative equilibria and the existence of Hopf-bifurcation by considering the discrete time delay as a bifurcation parameter. We estimate the length of delay to preserve the stability of bifurcating periodic solutions, which gives an idea about the mode of action for controlling oscillations in the tumor growth. Numerical simulations of the model confirm the analytical findings.

Suggested Citation

  • Khajanchi, Subhas, 2015. "Bifurcation analysis of a delayed mathematical model for tumor growth," Chaos, Solitons & Fractals, Elsevier, vol. 77(C), pages 264-276.
    • Handle: RePEc:eee:chsofr:v:77:y:2015:i:c:p:264-276
    DOI: 10.1016/j.chaos.2015.06.001
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    References listed on IDEAS

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    1. M. Saleem & Tanuja Agrawal, 2012. "Chaos in a Tumor Growth Model with Delayed Responses of the Immune System," Journal of Applied Mathematics, Hindawi, vol. 2012, pages 1-16, April.
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    Cited by:

    1. Liu, Xiangdong & Li, Qingze & Pan, Jianxin, 2018. "A deterministic and stochastic model for the system dynamics of tumor–immune responses to chemotherapy," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 500(C), pages 162-176.
    2. Dzyubak, Larysa & Dzyubak, Oleksandr & Awrejcewicz, Jan, 2023. "Nonlinear multiscale diffusion cancer invasion model with memory of states," Chaos, Solitons & Fractals, Elsevier, vol. 168(C).
    3. Khajanchi, Subhas & Nieto, Juan J., 2019. "Mathematical modeling of tumor-immune competitive system, considering the role of time delay," Applied Mathematics and Computation, Elsevier, vol. 340(C), pages 180-205.
    4. Liu, Yujuan & Lu, Qiong, 2020. "Hopf bifurcations in 3D competitive system with mixing exponential and rational growth rates," Applied Mathematics and Computation, Elsevier, vol. 378(C).
    5. Bera, Sovan & Khajanchi, Subhas & Roy, Tapan Kumar, 2022. "Dynamics of an HTLV-I infection model with delayed CTLs immune response," Applied Mathematics and Computation, Elsevier, vol. 430(C).
    6. Khajanchi, Subhas & Ghosh, Dibakar, 2015. "The combined effects of optimal control in cancer remission," Applied Mathematics and Computation, Elsevier, vol. 271(C), pages 375-388.
    7. Han, Haoming & Zhang, Jing & Liu, Yan, 2023. "Stability analysis of hybrid high-order nonlinear multiple time-delayed coupled systems via aperiodically intermittent control," Chaos, Solitons & Fractals, Elsevier, vol. 172(C).
    8. Khajanchi, Subhas, 2021. "The impact of immunotherapy on a glioma immune interaction model," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    9. Khajanchi, Subhas & Bera, Sovan & Roy, Tapan Kumar, 2021. "Mathematical analysis of the global dynamics of a HTLV-I infection model, considering the role of cytotoxic T-lymphocytes," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 180(C), pages 354-378.
    10. Khajanchi, Subhas, 2018. "Modeling the dynamics of glioma-immune surveillance," Chaos, Solitons & Fractals, Elsevier, vol. 114(C), pages 108-118.
    11. Duan, Wei-Long & Lin, Ling, 2021. "Noise and delay enhanced stability in tumor-immune responses to chemotherapy system," Chaos, Solitons & Fractals, Elsevier, vol. 148(C).
    12. Li, Qian & Xiao, Yanni, 2019. "Bifurcation analyses and hormetic effects of a discrete-time tumor model," Applied Mathematics and Computation, Elsevier, vol. 363(C), pages 1-1.
    13. Sardar, Mrinmoy & Biswas, Santosh & Khajanchi, Subhas, 2021. "The impact of distributed time delay in a tumor-immune interaction system," Chaos, Solitons & Fractals, Elsevier, vol. 142(C).

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