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Phenolic Antioxidants as Drugs for Alzheimer’s Disease: Oxidative Stress and Selectivity

Author

Listed:
  • Peter Kovacic

    (Department of Chemistry and Biochemistry, San Diego State University, USA)

  • Wil Weston

    (Library and Information Access, San Diego State University, USA)

Abstract

Oxidative stress (OS) is a well-recognized feature of Alzheimer’s disease. However, even up to the present time, there is controversy and conflicting results concerning the role of antioxidants (AO). This review provides evidence for the beneficial influence of phenols and phenolic ethers as AOs. Other mechanisms were advanced for these drugs previously; however, this report adds validity to the positive influence of AOs on Alzheimer’s disease. An important aspect to be recognized is the variability of action with a class based on competing pathways. The AOs involved are the following: curcumin, seasamol, rivastigmine, galantamine, donepezil, and piperine.

Suggested Citation

  • Peter Kovacic & Wil Weston, 2017. "Phenolic Antioxidants as Drugs for Alzheimer’s Disease: Oxidative Stress and Selectivity," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 3(2), pages 24-27, November.
    • Handle: RePEc:adp:jnapdd:v:3:y:2017:i:2:p:24-27
    DOI: 10.19080/NAPDD.2017.03.555606
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    References listed on IDEAS

    as
    1. Peter Kovacic & Ratnasamy Somanathan, 2017. "Mechanistic Aspects of Autism Involving Electron Transfer, Reactive Oxygen Species, Oxidative Stress, Pollutants, Antioxidants, Cell Signaling and Genes," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 1(3), pages 40-47, May.
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    Cited by:

    1. Peter Kovacic & Wil Weston, 2018. "Stroke: Unifying Mechanism Involving Antioxidant Therapy, Reactive Oxygen Species, and Oxidative Stress," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 4(4), pages 88-94, December.

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