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Mechanistic Aspects of Autism Involving Electron Transfer, Reactive Oxygen Species, Oxidative Stress, Pollutants, Antioxidants, Cell Signaling and Genes

Author

Listed:
  • Peter Kovacic
  • Ratnasamy Somanathan

    (Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182-1030, USA
    Centro de Graduados e Investigación del Instituto Tecnológico de Tijuana, Apdo. postal 1166, Tijuana, B.C. Mexico)

Abstract

Autism is a center of attention both in research and the media. This review is mainly concerned with mechanistic involvement of electron transfer, reactive oxygen species, oxidative stress and antioxidants, in addition to cell signaling and genetic aspects. Pollution from the environment is a factor. The most sensitive stage is the fetus. The neuronal network in the brain plays an important role. Antioxidants can act in prevention or amelioration. Interaction between the various aspects is addressed. The effect of vaccine is discussed.

Suggested Citation

  • Peter Kovacic & Ratnasamy Somanathan, 2017. "Mechanistic Aspects of Autism Involving Electron Transfer, Reactive Oxygen Species, Oxidative Stress, Pollutants, Antioxidants, Cell Signaling and Genes," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 1(3), pages 40-47, May.
  • Handle: RePEc:adp:jnapdd:v:1:y:2017:i:3:p:40-47
    DOI: 10.19080/NAPDD.2017.01.555562
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    Cited by:

    1. Peter Kovacic, 2017. "Phenolic Antioxidants as Drugs for Alzheimer’s Disease: Oxidative Stress and Selectivity," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 2(5), pages 95-97, October.
    2. Peter Kovacic & Wil Weston, 2017. "Phenolic Antioxidants as Drugs for Alzheimer’s Disease: Oxidative Stress and Selectivity," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 3(2), pages 24-27, November.

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