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Stroke: Unifying Mechanism Involving Antioxidant Therapy, Reactive Oxygen Species, and Oxidative Stress

Author

Listed:
  • Peter Kovacic

    (Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, USA)

  • Wil Weston

    (Library and Information Access, San Diego State University, San Diego, CA, USA)

Abstract

Reactive oxygen species (ROS) and oxidative stress (OS) play roles in stroke, as also in Alzheimer’s (AD), Parkinson’s (PD) disease and Schizophrenia (SCZ). Various sources, including oxidases, serve as generators of ROS-OS, such as mitochondria, NADPH, cytochromes P450, monoamines, ET metal complexes, G72 gene, and microglia. Many novel examples of antioxidants (AOs) exert a positive influence on the harmful effects, namely through a unifying mechanism based on ET-ROS-OS-AO. Drugs for treatment of stroke are discussed in relation to the unifying theme including phenolic and phenolic ethers.

Suggested Citation

  • Peter Kovacic & Wil Weston, 2018. "Stroke: Unifying Mechanism Involving Antioxidant Therapy, Reactive Oxygen Species, and Oxidative Stress," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 4(4), pages 88-94, December.
    • Handle: RePEc:adp:jnapdd:v:4:y:2018:i:4:p:88-94
    DOI: 10.19080/NAPDD.2018.04.555641
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    References listed on IDEAS

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    1. Peter Kovacic, 2017. "Phenolic Antioxidants as Drugs for Alzheimer’s Disease: Oxidative Stress and Selectivity," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 2(5), pages 95-97, October.
    2. Peter Kovacic & Wil Weston, 2017. "Phenolic Antioxidants as Drugs for Alzheimer’s Disease: Oxidative Stress and Selectivity," Novel Approaches in Drug Designing & Development, Juniper Publishers Inc., vol. 3(2), pages 24-27, November.
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