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Content
2025
- 42 Adverse Outcome Pathway on Deposition of Energy Leading to Learning and Memory Impairment
by Ahmad Sleiman & Kathleen Miller & Danicia Flores & Jacqueline Kuan & Kaitlyn Altwasser & Benjamin Smith & Hailey Adams & Tatiana Kozbenko & Robyn Hocking & Carole Yauk & Ruth Wilkins & Vinita Chauhan - 41 Adverse Outcome Pathway on Deposition of Energy Leading to Occurrence of Bone Loss
by Snehpal Sandhu & Mitchell Keyworth & Syna Karimi-Jashni & Dalya Alomar & Benjamin Smith & Tatiana Kozbenko & Robyn Hocking & Carole Yauk & Ruth C. Wilkins & Vinita Chauhan - 40 Adverse Outcome Pathway on Deposition of Energy Leading to Cataracts
by Emma Carrothers & Meghan Appleby & Vita Lai & Tatiana Kozbenko & Dalya Alomar & Benjamin Smith & Robyn Hocking & Carole Yauk & Ruth Wilkins & Vinita Chauhan - 39 Adverse Outcome Pathway on Deposition of Energy Leading to Abnormal Vascular Remodeling
by Tatiana Kozbenko & Nadine Adam & Veronica Grybas & Benjamin Smith & Dalya Alomar & Robyn Hocking & Janna Abdelaziz & Amanda Pace & Carole Yauk & Ruth Wilkins & Vinita Chauhan - 38 Adverse Outcome Pathway on Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
by Prarthana Shankar & Dan Villeneuve - 37 Adverse Outcome Pathway on Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
by Prarthana Shankar & Dan Villeneuve - 36 Adverse Outcome Pathway on Binding to voltage gate sodium channels during development leading to cognitive impairment
by Iris Mangas & Antonio F. Hernandez & Kevin Crofton & Mary Gilbert & Martin Paparella & Anna Price & Tim Shafer & Laura Martino & Martina Panzarea & Andrea Terron
2023
- 35 Adverse Outcome Pathway on Androgen receptor agonism leading to male-biased sex ratio
by Kelvin J. Santana Rodriguez & Daniel L. Villeneuve & Kathleen M. Jensen & Gerald T. Ankley & David H. Miller - 34 Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation
by Kelvin J. Santana Rodriguez & Daniel L. Villeneuve & Kathleen M. Jensen & Gerald T. Ankley & David H. Miller - 33 Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
by Sabina Halappanavar & Monita Sharma & Silvia Solorio-Rodriguez & Hakan Wallin & Ulla Vogel & Kristie Sullivan & Amy J. Clippinger - 32 Adverse Outcome Pathway on deposition of energy leading to lung cancer
by Samantha Sherman & Zakara Said & Baki Sadi & Carole Yauk & Danielle Beaton & Ruth Wilkins & Robert Stainforth & Nadine Adam & Vinita Chauhan - 31 Disruption of VEGFR signaling leading to developmental defects
by Thomas B. Knudsen & Katerine Saili & Jill Franzosa & Nancy Baker & Richard Spencer & Tamara Tal & Nicole Kleinstreuer & Tuula Heinonen & Rob Ellis-Hutchings & Neil Vargesson & Maria Bondesson - 30 Adverse Outcome Pathway on impaired interleukin-1 receptor type I (IL-1R1) signaling leading to impaired T-cell dependent antibody response
by Yutaka Kimura & Setsuya Aiba & Takao Ashikaga & Takumi Ohishi & Kiyoshi Kushima - 29 Oxidative DNA damage leading to chromosomal aberrations and mutations
by Eunnara Cho & Ashley Allemang & Marc Audebert & Vinita Chauhan & Stephen Dertinger & Giel Hendriks & Mirjam Luijten & Francesco Marchetti & Sheroy Minocherhomji & Stefan Pfuhler & Daniel J. Roberts & Kristina Trenz & Carole L. Yauk
2022
- 28 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
by You Song & Daniel L. Villeneuve - 27 Chitin synthase 1 inhibition leading to mortality
by Simon Schmid & You Song & Knut Erik Tollefsen - 26 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
by Lucia Vergauwen & Evelyn Stinckens & Daniel L. Villeneuve & Dries Knapen - 25 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
by Lucia Vergauwen & Evelyn Stinckens & Daniel L. Villeneuve & Dries Knapen - 24 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
by Lucia Vergauwen & Evelyn Stinckens & Daniel L. Villeneuve & Dries Knapen - 23 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
by Lucia Vergauwen & Evelyn Stinckens & Daniel L. Villeneuve & Dries Knapen - 22 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
by Lucia Vergauwen & Evelyn Stinckens & Daniel L. Villeneuve & Dries Knapen - 21 Inhibitor binding to topoisomerase II leading to infant leukaemia
by Olavi Pelkonen & Andrea Terron & Antonio F. Hernandez & Pablo Menendez & Susanne Hougaard Bennekou - 20 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory
by Florianne Tschudi-Monnet & Marie-Gabrielle Zurich & Carolina Nunes & Jenny Sandström & Rex FitzGerald & Michael Aschner & Joao Rocha
2021
- 19 Adverse Outcome Pathway on Cyp2E1 activation leading to liver cancer
by Francina Webster & Iain B. Lambert & Carole L. Yauk - 18 Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response
by Hiroyuki Komatsu & Junichiro Sugimoto & Ken Goto & Kiyoshi Kushima & Naohisa Tsutsui & Shigeru Hisada & Shiho Ito & Tadashi Kosaka & Takumi Ohishi & Yasuharu Otsubo & Yoshihiro Takahashi - 17 Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy
by Shihori Tanabe & Akihiko Hirose & Takashi Yamada
2019
- 16 Adverse Outcome Pathway on Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
by Amani Farhat & Sean W. Kennedy - 15 Adverse Outcome Pathway on Aryl hydrocarbon receptor activation leading to uroporphyria
by Amani Farhat & Gillian Manning & Jason O’Brien & Sean W. Kennedy - 14 Adverse Outcome Pathway on inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
by Alexandra Rolaki & Francesca Pistollato & Sharon Munn & Anna Bal-Price - 13 Adverse Outcome Pathway on inhibition of Thyroperoxidase and subsequent adverse neurodevelopmental outcomes in mammals
by Kevin M. Crofton & Mary Gilbert & Katie Paul Friedman & Barbara Demeneix & Mary Sue Marty & R. Thomas Zoeller - 12 Adverse Outcome Pathway on aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
by Jon Doering & Markus Hecker & Daniel L. Villeneuve & Xiaowei Zhang - 11 Adverse Outcome Pathway on binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
by Ping Gong & Edward J. Perkins - 10 Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss
by Kurt A. Gust & Mitchell S. Wilbanks & Zachary A. Collier & Lyle D. Burgoon & Edward J. Perkins
2018
- 9 Adverse Outcome Pathway on Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
by Daniel L. Villeneuve - 8 Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors during brain development leading to neurodegeneration with impairment in learning and memory in aging
by Florianne Tschudi-Monnet & Rex FitzGerald - 7 Adverse Outcome Pathway on Inhibition of the mitochondrial complex I of nigro-striatal neurons leading to parkinsonian motor deficits
by Anna Bal-Price & Marcel Leist & Stefan Schildknecht & Florianne Tschudi-Monnet & Alicia Paini & Andrea Terron - 1 Users' Handbook supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways
by Oecd
2016
- 6 Adverse Outcome Pathway on binding of agonists to ionotropic glutamate receptors in adult brain leading to excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment
by Magdalini Sachana & Sharon Munn & Anna Bal-Price - 5 Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
by Magdalini Sachana & Sharon Munn & Anna Bal-Price - 4 Adverse Outcome Pathway on Aromatase Inhibition Leading to Reproductive Dysfunction (in Fish)
by Daniel L. Villeneuve - 3 Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations
by Carole Yauk & Iain Lambert & Francesco Marchetti & George Douglas - 2 Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis
by Brigitte Landesmann