IDEAS home Printed from https://ideas.repec.org/p/oec/envaad/36-en.html
   My bibliography  Save this paper

Adverse Outcome Pathway on Binding to voltage gate sodium channels during development leading to cognitive impairment

Author

Listed:
  • Iris Mangas
  • Antonio F. Hernandez
  • Kevin Crofton
  • Mary Gilbert
  • Martin Paparella
  • Anna Price
  • Tim Shafer
  • Laura Martino
  • Martina Panzarea
  • Andrea Terron

Abstract

This adverse outcome pathway links the binding of xenobiotics to voltage gate sodium channels (VGSCs) during development, to cognitive impairment. The binding of xenobiotics to VGSCs may lead to disruption of action potential generation and consequently to an alteration in neurotransmission. Neurotransmitter release is essential for neural activity and neural activity is critical for normal brain development. Therefore, chemicals that bind with VGSCs have the potential to cause adverse effects on the developing brain. This AOP focuses on the hippocampus because of its well-known ties to cognition, and downstream outcome of concern for many chemical exposures. This AOP is referred to as AOP 442 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki): https://aopwiki.org.

Suggested Citation

  • Iris Mangas & Antonio F. Hernandez & Kevin Crofton & Mary Gilbert & Martin Paparella & Anna Price & Tim Shafer & Laura Martino & Martina Panzarea & Andrea Terron, 2025. "Adverse Outcome Pathway on Binding to voltage gate sodium channels during development leading to cognitive impairment," OECD Series on Adverse Outcome Pathways 36, OECD Publishing.
    • Handle: RePEc:oec:envaad:36-en
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a search for a similarly titled item that would be available.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:oec:envaad:36-en. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: the person in charge (email available below). General contact details of provider: https://edirc.repec.org/data/enoecfr.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.