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Content
November 2025, Volume 647, Issue 8088
- 143-156 Transcriptomic and spatial organization of telencephalic GABAergic neurons
by Cindy T. J. Velthoven & Yuan Gao & Michael Kunst & Changkyu Lee & Delissa McMillen & Anish Bhaswanth Chakka & Tamara Casper & Michael Clark & Rushil Chakrabarty & Scott Daniel & Tim Dolbeare & Rebecca Ferrer & Jessica Gloe & Jeff Goldy & Junitta Guzman & Carliana Halterman & Windy Ho & Mike J. Huang & Katelyn James & Rachel McCue & Beagan Nguy & Trangthanh Cardenas & Kara Ronellenfitch & Emma D. Thomas & Amy Torkelson & Chelsea M. Pagan & Lauren Kruse & Nick Dee & Lydia Ng & Jack Waters & Kimberly A. Smith & Bosiljka Tasic & Zizhen Yao & Hongkui Zeng - 157-168 Sensory input, sex and function shape hypothalamic cell type development
by Harris S. Kaplan & Brandon L. Logeman & Kai Zhang & Tate A. Yawitz & Celine Santiago & Noor Sohail & Mustafa Talay & Changwoo Seo & Serhiy Naumenko & Shannan J. Ho Sui & David D. Ginty & Bing Ren & Catherine Dulac - 169-178 Molecular and cellular dynamics of the developing human neocortex
by Li Wang & Cheng Wang & Juan A. Moriano & Songcang Chen & Guolong Zuo & Arantxa Cebrián-Silla & Shaobo Zhang & Tanzila Mukhtar & Shaohui Wang & Mengyi Song & Lilian Gomes Oliveira & Qiuli Bi & Jonathan J. Augustin & Xinxin Ge & Mercedes F. Paredes & Eric J. Huang & Arturo Alvarez-Buylla & Xin Duan & Jingjing Li & Arnold R. Kriegstein - 179-186 Chromatin accessibility during human first-trimester neurodevelopment
by Camiel C. A. Mannens & Lijuan Hu & Peter Lönnerberg & Marijn Schipper & Caleb C. Reagor & Xiaofei Li & Xiaoling He & Roger A. Barker & Erik Sundström & Danielle Posthuma & Sten Linnarsson - 187-193 Conservation and alteration of mammalian striatal interneurons
by Emily K. Corrigan & Michael DeBerardine & Aunoy Poddar & Miguel Turrero García & Sean de la O & Siting He & Harsha Sen & Mariana Duhne & Shanti Lindberg & Mengyi Song & Matthew T. Schmitz & Karen E. Sears & Ricardo Mallarino & Joshua D. Berke & Corey C. Harwell & Mercedes F. Paredes & Fenna M. Krienen & Alex A. Pollen - 194-202 Lineage-resolved atlas of the developing human cortex
by Matthew G. Keefe & Marilyn R. Steyert & Tomasz J. Nowakowski - 203-212 Whole-cortex in situ sequencing reveals input-dependent area identity
by Xiaoyin Chen & Stephan Fischer & Mara C. P. Rue & Aixin Zhang & Didhiti Mukherjee & Patrick O. Kanold & Jesse Gillis & Anthony M. Zador - 213-227 Spatial dynamics of brain development and neuroinflammation
by Di Zhang & Leslie A. Rubio Rodríguez-Kirby & Yingxin Lin & Wenqi Wang & Mengyi Song & Li Wang & Lijun Wang & Shigeaki Kanatani & Tony Jimenez-Beristain & Yonglong Dang & Mei Zhong & Petra Kukanja & Shuozhen Bao & Shaohui Wang & Xinyi Lisa Chen & Fu Gao & Dejiang Wang & Hang Xu & Cong Ma & Xing Lou & Yang Liu & Jinmiao Chen & Nenad Sestan & Per Uhlén & Arnold Kriegstein & Hongyu Zhao & Gonçalo Castelo-Branco & Rong Fan - 228-237 Repeated head trauma causes neuron loss and inflammation in young athletes
by Morgane L. M. D. Butler & Nida Pervaiz & Kerry Breen & Samantha Calderazzo & Petra Ypsilantis & Yichen Wang & Julia Cammasola Breda & Sarah Mazzilli & Raymond Nicks & Elizabeth Spurlock & Marco M. Hefti & Kimberly L. Fiock & Bertrand R. Huber & Victor E. Alvarez & Thor D. Stein & Joshua D. Campbell & Ann C. McKee & Jonathan D. Cherry - 238-247 A human-specific regulatory mechanism revealed in a pre-implantation model
by Raquel Fueyo & Sicong Wang & Olivia J. Crocker & Tomek Swigut & Hiromitsu Nakauchi & Joanna Wysocka - 248-256 Learning the natural history of human disease with generative transformers
by Artem Shmatko & Alexander Wolfgang Jung & Kumar Gaurav & Søren Brunak & Laust Hvas Mortensen & Ewan Birney & Tom Fitzgerald & Moritz Gerstung - 257-267 Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
by Abbie S. Ireland & Daniel A. Xie & Sarah B. Hawgood & Margaret W. Barbier & Lisa Y. Zuo & Benjamin E. Hanna & Scarlett Lucas-Randolph & Darren R. Tyson & Benjamin L. Witt & Ramaswamy Govindan & Afshin Dowlati & Justin C. Moser & Anish Thomas & Sonam Puri & Charles M. Rudin & Joseph M. Chan & Andrew Elliott & Trudy G. Oliver - 268-276 Covariation MS uncovers a protein that controls cysteine catabolism
by Haopeng Xiao & Martha Ordonez & Emma C. Fink & Taylor A. Covington & Hilina B. Woldemichael & Junyi Chen & Mika Sarkin Jain & Milan H. Rohatgi & Shelley M. Wei & Nils Burger & Muneeb A. Sharif & Julius Jan & Yaoyu Wang & Jonathan J. Petrocelli & Katherine Blackmore & Amanda L. Smythers & Bingsen Zhang & Matthew Gilbert & Hakyung Cheong & Sumeet A. Khetarpal & Arianne Smith & Dina Bogoslavski & Yu Lei & Laura Pontano Vaites & Fiona E. McAllister & Nick Bruggen & Katherine A. Donovan & Edward L. Huttlin & Evanna L. Mills & Eric S. Fischer & Edward T. Chouchani - 277-279 Insiders warn how dismantling federal agencies could put science at risk
by Virginia Gewin - 282-282 From pangolins to primates: how I use zoo facilities to treat wild animals
by Jack Leeming
October 2025, Volume 646, Issue 8087
- 18-19 Carbon implications of wood harvesting and forest management
by Brent Sohngen & Justin S. Baker & Alice Favero & Adam Daigneault - 20-23 Reply to: Carbon implications of wood harvesting and forest management
by Timothy D. Searchinger & Steven Berry & Liqing Peng - 24-25 On anisotropy in cubic Cu2O photoelectrodes
by Yuhao Fu & David J. Singh - 26-27 Reply to: On anisotropy in cubic Cu2O photoelectrodes
by Linfeng Pan & Linjie Dai & Oliver J. Burton & Lu Chen & Virgil Andrei & Youcheng Zhang & Dan Ren & Jinshui Cheng & Linxiao Wu & Kyle Frohna & Anna Abfalterer & Terry Chien-Jen Yang & Wenzhe Niu & Meng Xia & Stephan Hofmann & Paul J. Dyson & Erwin Reisner & Henning Sirringhaus & Jingshan Luo & Anders Hagfeldt & Michael Grätzel & Samuel D. Stranks - 28-28 Author Correction: Crystal structure of heliorhodopsin
by Wataru Shihoya & Keiichi Inoue & Manish Singh & Masae Konno & Shoko Hososhima & Keitaro Yamashita & Kento Ikeda & Akimitsu Higuchi & Tamaki Izume & Sae Okazaki & Masanori Hashimoto & Ritsu Mizutori & Sahoko Tomida & Yumeka Yamauchi & Rei Abe-Yoshizumi & Kota Katayama & Satoshi P. Tsunoda & Mikihiro Shibata & Yuji Furutani & Alina Pushkarev & Oded Béjà & Takayuki Uchihashi & Hideki Kandori & Osamu Nureki - 29-30 Author Correction: Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy
by Elisabeth Perez-Ruiz & Luna Minute & Itziar Otano & Maite Alvarez & Maria Carmen Ochoa & Virginia Belsue & Carlos de Andrea & Maria Esperanza Rodriguez-Ruiz & Jose Luis Perez-Gracia & Ivan Marquez-Rodas & Casilda Llacer & Martina Alvarez & Vanesa de Luque & Carmen Molina & Alvaro Teijeira & Pedro Berraondo & Ignacio Melero - 31-31 Author Correction: Ribonucleotide incorporation into mitochondrial DNA drives inflammation
by Amir Bahat & Dusanka Milenkovic & Eileen Cors & Mabel Barnett & Sadig Niftullayev & Athanasios Katsalifis & Marc Schwill & Petra Kirschner & Thomas MacVicar & Patrick Giavalisco & Louise Jenninger & Anders R. Clausen & Vincent Paupe & Julien Prudent & Nils-Göran Larsson & Manuel Rogg & Christoph Schell & Isabella Muylaert & Erik Larsson & Hendrik Nolte & Maria Falkenberg & Thomas Langer - 32-32 Author Correction: EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells
by Jianhua Li & Erick Lu & Tangsheng Yi & Jason G. Cyster - 33-33 Publisher Correction: Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors
by Ling-Xiao Shao & Clara Liao & Pasha A. Davoudian & Neil K. Savalia & Quan Jiang & Cassandra Wojtasiewicz & Diran Tan & Jack D. Nothnagel & Rong-Jian Liu & Samuel C. Woodburn & Olesia M. Bilash & Hail Kim & Alicia Che & Alex C. Kwan - 39-41 How nanobots are accelerating cancer-targeting therapies
by Amanda Heidt - 1027-1027 We need a new Turing test to assess AI’s real-world knowledge
by Vinay K. Chaudhri - 1028-1028 What now for the global plastics treaty?
by Maria Ivanova - 1031-1032 Blood tests are now approved for Alzheimer’s: how accurate are they?
by Katie Kavanagh - 1032-1033 What’s the cap on human energy expenditure? Elite athletes reveal ‘metabolic ceiling’
by Mohana Basu - 1033-1033 Surprise meteorite debris uncovered on Moon’s far side
by Jenna Ahart - 1034-1035 How scientists are pushing back against Trump’s funding ‘deal’ for universities
by Dan Garisto & Alexandra Witze & Jenna Ahart - 1035-1036 People with blindness can read again after retinal implant
by Liam Drew - 1036-1037 Is academic research becoming too competitive? Nature examines the data
by Miryam Naddaf - 1038-1038 The world’s first plastics treaty is in crisis: can it be salvaged?
by Katharine Sanderson - 1040-1043 7 basic science discoveries that changed the world
by Michael Marshall - 1044-1046 Plants have a secret language that scientists are only now starting to decipher
by Amber Dance - 1048-1049 AI can supercharge inequality — unless the public learns to control it
by Cathy O’Neil - 1050-1051 How do you know what I know you know? Steven Pinker on common knowledge
by David Adam - 1053-1053 John Gurdon obituary: Biologist who made cloning possible
by Ron Laskey - 1054-1056 Environmental treaties are paralysed — here’s how we can do better
by Rakhyun E. Kim & Peter Bridgewater - 1057-1059 How to understand exoplanets — space scientists call on lab-based chemists to help
by Frank A. F. Winiberg & Laura Kreidberg & Julianne I. Moses & Carl J. Percival & Paul I. Palmer - 1060-1060 Treat children as citizen co-researchers in health technology
by Melike Şahinol - 1060-1060 Ethics must keep pace with embryo research
by Tsutomu Sawai - 1060-1060 Don’t overlook the plastic footprint of fireworks
by Kai Liu & Zongbo Shi & Yulan Zhang & Daoji Li - 1060-1060 Universities can harness AI to make learning intuitive
by Shuaiguo Wang - 1061-1062 Ultrasound-driven artificial muscles can grasp, flex and swim
by Joseph Rufo & Tony Jun Huang - 1062-1063 Distorted representations of age and gender are reflected in AI models
by Ana Macanovic - 1064-1065 Early- and late-diagnosed autism are genetically distinct
by Elliot M. Tucker-Drob - 1065-1067 To make water, exoplanets might just need some pressure
by Quentin Williams - 1067-1068 Wired for growth: neuron–tumour signalling in the lung and brain increases growth of a hard-to-treat cancer
by Abbie S. Ireland & Trudy G. Oliver - 1069-1074 Building wet planets through high-pressure magma–hydrogen reactions
by H. W. Horn & A. Vazan & S. Chariton & V. B. Prakapenka & S.-H. Shim - 1075-1080 Continuous operation of a coherent 3,000-qubit system
by Neng-Chun Chiu & Elias C. Trapp & Jinen Guo & Mohamed H. Abobeih & Luke M. Stewart & Simon Hollerith & Pavel L. Stroganov & Marcin Kalinowski & Alexandra A. Geim & Simon J. Evered & Sophie H. Li & Xingjian Lyu & Lisa M. Peters & Dolev Bluvstein & Tout T. Wang & Markus Greiner & Vladan Vuletić & Mikhail D. Lukin - 1081-1088 A full-featured 2D flash chip enabled by system integration
by Chunsen Liu & Yongbo Jiang & Boqian Shen & Shengchao Yuan & Zhenyuan Cao & Zhongyu Bi & Chong Wang & Yutong Xiang & Tanjun Wang & Haoqi Wu & Zizheng Liu & Yang Wang & Shuiyuan Wang & Peng Zhou - 1089-1095 Video‐rate tunable colour electronic paper with human resolution
by Ade Satria Saloka Santosa & Yu-Wei Chang & Andreas B. Dahlin & Lars Österlund & Giovanni Volpe & Kunli Xiong - 1096-1104 Ultrasound-driven programmable artificial muscles
by Zhan Shi & Zhiyuan Zhang & Justus Schnermann & Stephan C. F. Neuhauss & Nitesh Nama & Raphael Wittkowski & Daniel Ahmed - 1105-1113 Decoding the redox behaviour of copper in Ullmann-type coupling reactions
by Yongrui Luo & Yuli Li & Botao Wu & Guangyu Wang & Jian Wu & Sheng-Ye Zhang & K. N. Houk & Qilong Shen - 1114-1121 A circular economy approach for the global lithium-ion battery supply chain
by Mengyu Zhai & Yufeng Wu & Shaonan Tian & Haoran Yuan & Bin Li & Xubiao Luo & Guohe Huang & Yupeng Fu & Mengye Zhu & Yifan Gu & Wei Huan & Yu Dai & Huaidong Wang & Liming Yang & Xiaofei Yin & Gongqi Liu & Zhi Li & Jing Gu & Yazhuo Wang & Yong Chen & Tieyong Zuo - 1122-1128 Magnetotelluric evidence for a melt-rich magmatic reservoir beneath Mayotte
by Pierre Wawrzyniak & Fabrice Gaillard & Sophie Hautot & Juan Andujar & Pascal Tarits & Laurent Arbaret & Samuel Guegan & David Sifré & Jean-François D’Eu & Jacques Deparis & Anne Lemoine & Isabelle Thinon & Sheldon Warden & Frédéric Dubois - 1129-1137 Age and gender distortion in online media and large language models
by Douglas Guilbeault & Solène Delecourt & Bhargav Srinivasa Desikan - 1138-1145 A domed pachycephalosaur from the early Cretaceous of Mongolia
by Tsogtbaatar Chinzorig & Ryuji Takasaki & Junki Yoshida & Ryan T. Tucker & Batsaikhan Buyantegsh & Buuvei Mainbayar & Khishigjav Tsogtbaatar & Lindsay E. Zanno - 1146-1155 Polygenic and developmental profiles of autism differ by age at diagnosis
by Xinhe Zhang & Jakob Grove & Yuanjun Gu & Cornelia K. Buus & Lea K. Nielsen & Sharon A. S. Neufeld & Mahmoud Koko & Daniel S. Malawsky & Emma M. Wade & Ellen Verhoef & Anna Gui & Laura Hegemann & Daniel H. Geschwind & Naomi R. Wray & Alexandra Havdahl & Angelica Ronald & Beate Pourcain & Elise B. Robinson & Thomas Bourgeron & Simon Baron-Cohen & Anders D. Børglum & Hilary C. Martin & Varun Warrier - 1156-1166 Transitions in dynamical regime and neural mode during perceptual decisions
by Thomas Zhihao Luo & Timothy Doyeon Kim & Diksha Gupta & Adrian G. Bondy & Charles D. Kopec & Verity A. Elliott & Brian DePasquale & Carlos D. Brody - 1167-1177 A neuronal architecture underlying autonomic dysreflexia
by Jan Elaine Soriano & Remi Hudelle & Lois Mahe & Matthieu Gautier & Alan Yue Yang Teo & Michael A. Skinnider & Achilleas Laskaratos & Steven Ceto & Claudia Kathe & Thomas Hutson & Rebecca Charbonneau & Fady Girgis & Steve Casha & Julien Rimok & Marcus Tso & Kelly Larkin-Kaiser & Nicolas Hankov & Aasta Gandhi & Suje Amir & Xiaoyang Kang & Yashwanth Vyza & Eduardo Martin-Moraud & Stephanie Lacour & Robin Demesmaeker & Leonie Asboth & Quentin Barraud & Mark A. Anderson & Jocelyne Bloch & Jordan W. Squair & Aaron A. Phillips & Gregoire Courtine - 1178-1186 PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia
by Alena Kozlova & Siwei Zhang & Ari Sudwarts & Hanwen Zhang & Stanislau Smirnou & Seul Kee Byeon & Christina Thapa & Xiaotong Sun & Kimberley Stephenson & Xiaojie Zhao & Brendan Jamison & Moorthi Ponnusamy & Xin He & Julie A. Schneider & Akhilesh Pandey & David A. Bennett & Zhiping P. Pang & Alan R. Sanders & Hugo J. Bellen & Gopal Thinakaran & Jubao Duan - 1187-1194 Energy deficiency selects crowded live epithelial cells for extrusion
by Saranne J. Mitchell & Carlos Pardo-Pastor & Anastassia Tchoumakova & Thomas A. Zangle & Jody Rosenblatt - 1195-1203 Programmable antisense oligomers for phage functional genomics
by Milan Gerovac & Leandro Buhlmann & Yan Zhu & Svetlana Ðurica-Mitić & Valentin Rech & Samuel Carien & Tom Gräfenhan & Linda Popella & Jörg Vogel - 1204-1213 Monoclonal antibodies protect against pandrug-resistant Klebsiella pneumoniae
by Emanuele Roscioli & Vittoria Zucconi Galli Fonseca & Soraya Soledad Bosch & Ida Paciello & Giuseppe Maccari & Giulia Cardinali & Giampiero Batani & Samuele Stazzoni & Giusy Tiseo & Cesira Giordano & Shen Yuwei & Laura Capoccia & Dario Cardamone & Matteo Ridelfi & Marco Troisi & Noemi Manganaro & Chiara Mugnaini & Concetta De Santi & Annalisa Ciabattini & Linda Cerofolini & Marco Fragai & Danilo Licastro & Kelly Wyres & Laurent Dortet & Simona Barnini & David P. Nicolau & Francesco Menichetti & Marco Falcone & Kamilia Abdelraouf & Claudia Sala & Anna Kabanova & Rino Rappuoli - 1214-1222 Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
by Samarth Hegde & Bruno Giotti & Brian Y. Soong & Laszlo Halasz & Jessica Berichel & Maximilian M. Schaefer & Benoit Kloeckner & Raphaël Mattiuz & Matthew D. Park & Assaf Magen & Adam Marks & Meriem Belabed & Pauline Hamon & Theodore Chin & Leanna Troncoso & Juliana J. Lee & Kaili Fan & Dughan Ahimovic & Michael J. Bale & Kai Nie & Grace Chung & Darwin D’souza & Krista Angeliadis & Seunghee Kim-Schulze & Raja M. Flores & Andrew J. Kaufman & Florent Ginhoux & Jason D. Buenrostro & Steven Z. Josefowicz & Alexander M. Tsankov & Thomas U. Marron & Sai Ma & Brian D. Brown & Miriam Merad - 1223-1231 Peroxisomal metabolism of branched fatty acids regulates energy homeostasis
by Xuejing Liu & Anyuan He & Dongliang Lu & Donghua Hu & Min Tan & Abenezer Abere & Parniyan Goodarzi & Bilal Ahmad & Brian Kleiboeker & Brian N. Finck & Mohamed Zayed & Katsuhiko Funai & Jonathan R. Brestoff & Ali Javaheri & Patricia Weisensee & Bettina Mittendorfer & Fong-Fu Hsu & Paul P. Veldhoven & Babak Razani & Clay F. Semenkovich & Irfan J. Lodhi - 1232-1242 Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis
by Solomiia Savchuk & Kaylee M. Gentry & Wengang Wang & Elana Carleton & Carlos A. O. Biagi-Junior & Karan Luthria & Belgin Yalçın & Lijun Ni & Hannah C. Farnsworth & Rachel A. Davis & Richard Drexler & Johannes C. Melms & Yin Liu & Lehi Acosta-Alvarez & Griffin G. Hartmann & Elisa C. Pavarino & Jenna LaBelle & Pamelyn J. Woo & Angus M. Toland & Fangfei Qu & Yoon Seok Kim & Mariella G. Filbin & Mark A. Krasnow & Keith L. Ligon & Benjamin Izar & Julien Sage & Bernardo L. Sabatini & Michelle Monje & Humsa S. Venkatesh - 1243-1253 Functional synapses between neurons and small cell lung cancer
by Vignesh Sakthivelu & Anna Schmitt & Franka Odenthal & Kristiano Ndoci & Marian Touet & Ali H. Shaib & Abdulla Chihab & Gulzar A. Wani & Pascal Nieper & Griffin G. Hartmann & Isabel Pintelon & Ilmars Kisis & Maike Boecker & Naja M. Eckert & Manoela Iannicelli Caiaffa & Olta Ibruli & Julia Weber & Roman Maresch & Christina M. Bebber & Ali Chitsaz & Anna Lütz & Mira Kim Alves Carpinteiro & Kaylee M. Morris & Camilla A. Franchino & Jonas Benz & Laura Pérez-Revuelta & Jorge A. Soriano-Campos & Maxim A. Huetzen & Jonas Goergens & Milica Jevtic & Hannah M. Jahn-Kelleter & Hans Zempel & Aleksandra Placzek & Alexandru A. Hennrich & Karl-Klaus Conzelmann & Hannah L. Tumbrink & Pascal Hunold & Joerg Isensee & Lisa Werr & Felix Gaedke & Astrid Schauss & Marielle Minère & Marie Müller & Henning Fenselau & Yin Liu & Alena Heimsoeth & Gülce S. Gülcüler Balta & Henning Walczak & Christian Frezza & Ron D. Jachimowicz & Julie George & Marcel Schmiel & Johannes Brägelmann & Tim Hucho & Silvia Karstedt & Martin Peifer & Alessandro Annibaldi & Robert Hänsel-Hertsch & Thorsten Persigehl & Holger Grüll & Martin L. Sos & Guido Reifenberger & Matthias Fischer & Dirk Adriaensen & Reinhard Büttner & Julien Sage & Inge Brouns & Roland Rad & Roman K. Thomas & Max Anstötz & Silvio O. Rizzoli & Matteo Bergami & Elisa Motori & Hans Christian Reinhardt & Filippo Beleggia - 1254-1260 Engineered prime editors with minimal genomic errors
by Vikash P. Chauhan & Phillip A. Sharp & Robert Langer - 1261-1271 Spatial joint profiling of DNA methylome and transcriptome in tissues
by Chin Nien Lee & Hongxiang Fu & Angelysia Cardilla & Wanding Zhou & Yanxiang Deng - 1272-1280 Structure and mechanism of the mitochondrial calcium transporter NCLX
by Minrui Fan & Chen-Wei Tsai & Jinru Zhang & Jianxiu Zhang & Aswini R. Krishnan & Tsung-Yun Liu & Yu-Lun Huang & Deniz Aydin & Siyuan Du & Briana L. Sobecks & Madison X. Rodriguez & Andrew H. Reiter & Carolyn R. Bertozzi & Ron O. Dror & Ming-Feng Tsai & Liang Feng - 1281-1282 Cake to the rescue: how these PhD students are cooking up a sense of community
by Sarah Wells - 1284-1284 Preserving Pompeii’s past, one step at a time
by Agnese Abrusci
October 2025, Volume 646, Issue 8086
- 4-9 Uncertain climate effects of anthropogenic reactive nitrogen
by Øivind Hodnebrog & Caroline Jouan & Didier A. Hauglustaine & Fabien Paulot & Susanne E. Bauer & Maureen Beaudor & Michael J. Prather & Marit Sandstad & Ragnhild B. Skeie & Gunnar Myhre - 10-12 Reply to: Uncertain climate effects of anthropogenic reactive nitrogen
by Cheng Gong & Hanqin Tian & Hong Liao & Naiqing Pan & Shufen Pan & Akihiko Ito & Atul K. Jain & Sian Kou-Giesbrecht & Fortunat Joos & Qing Sun & Hao Shi & Nicolas Vuichard & Qing Zhu & Changhui Peng & Federico Maggi & Fiona H. M. Tang & Sönke Zaehle - 13-13 Author Correction: Clonal dynamics and somatic evolution of haematopoiesis in mouse
by Chiraag D. Kapadia & Nicholas Williams & Kevin J. Dawson & Caroline Watson & Matthew J. Yousefzadeh & Duy Le & Kudzai Nyamondo & Sreeya Kodavali & Alex Cagan & Sarah Waldvogel & Xiaoyan Zhang & Josephine Fuente & Daniel Leongamornlert & Emily Mitchell & Marcus A. Florez & Krzysztof Sosnowski & Rogelio Aguilar & Alejandra Martell & Anna Guzman & David Harrison & Laura J. Niedernhofer & Katherine Y. King & Peter J. Campbell & Jamie Blundell & Margaret A. Goodell & Jyoti Nangalia - 14-14 Author Correction: Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection
by Ilaria Ceppi & Maria Rosaria Dello Stritto & Martin Mütze & Stefan Braunshier & Valentina Mengoli & Giordano Reginato & Hồ Mỹ Phúc Võ & Sonia Jimeno & Ananya Acharya & Megha Roy & Aurore Sanchez & Swagata Halder & Sean Michael Howard & Raphaël Guérois & Pablo Huertas & Sylvie M. Noordermeer & Ralf Seidel & Petr Cejka - 15-15 Author Correction: Selenium-alloyed tellurium oxide for amorphous p-channel transistors
by Ao Liu & Yong-Sung Kim & Min Gyu Kim & Youjin Reo & Taoyu Zou & Taesu Choi & Sai Bai & Huihui Zhu & Yong-Young Noh - 16-16 Publisher Correction: Multimodal cell maps as a foundation for structural and functional genomics
by Leah V. Schaffer & Mengzhou Hu & Gege Qian & Kyung-Mee Moon & Abantika Pal & Neelesh Soni & Andrew P. Latham & Laura Pontano Vaites & Dorothy Tsai & Nicole M. Mattson & Katherine Licon & Robin Bachelder & Anthony Cesnik & Ishan Gaur & Trang Le & William Leineweber & Aji Palar & Ernst Pulido & Yue Qin & Xiaoyu Zhao & Christopher Churas & Joanna Lenkiewicz & Jing Chen & Keiichiro Ono & Dexter Pratt & Peter Zage & Ignacia Echeverria & Andrej Sali & J. Wade Harper & Steven P. Gygi & Leonard J. Foster & Edward L. Huttlin & Emma Lundberg & Trey Ideker - 17-17 Publisher Correction: Functional synapses between neurons and small cell lung cancer
by Vignesh Sakthivelu & Anna Schmitt & Franka Odenthal & Kristiano Ndoci & Marian Touet & Ali H. Shaib & Abdulla Chihab & Gulzar A. Wani & Pascal Nieper & Griffin G. Hartmann & Isabel Pintelon & Ilmars Kisis & Maike Boecker & Naja M. Eckert & Manoela Iannicelli Caiaffa & Olta Ibruli & Julia Weber & Roman Maresch & Christina M. Bebber & Ali Chitsaz & Anna Lütz & Mira Kim Alves Carpinteiro & Kaylee M. Morris & Camilla A. Franchino & Jonas Benz & Laura Pérez-Revuelta & Jorge A. Soriano-Campos & Maxim A. Huetzen & Jonas Goergens & Milica Jevtic & Hannah M. Jahn-Kelleter & Hans Zempel & Aleksandra Placzek & Alexandru A. Hennrich & Karl-Klaus Conzelmann & Hannah L. Tumbrink & Pascal Hunold & Joerg Isensee & Lisa Werr & Felix Gaedke & Astrid Schauss & Marielle Minère & Marie Müller & Henning Fenselau & Yin Liu & Alena Heimsoeth & Gülce S. Gülcüler Balta & Henning Walczak & Christian Frezza & Ron D. Jachimowicz & Julie George & Marcel Schmiel & Johannes Brägelmann & Tim Hucho & Silvia Karstedt & Martin Peifer & Alessandro Annibaldi & Robert Hänsel-Hertsch & Thorsten Persigehl & Holger Grüll & Martin L. Sos & Guido Reifenberger & Matthias Fischer & Dirk Adriaensen & Reinhard Büttner & Julien Sage & Inge Brouns & Roland Rad & Roman K. Thomas & Max Anstötz & Silvio O. Rizzoli & Matteo Bergami & Elisa Motori & Hans Christian Reinhardt & Filippo Beleggia - 23-23 We need more than good science to fight infectious disease
by Bec Crew - 24-27 Measles, polio, tuberculosis: what’s causing spikes in infectious diseases?
by Rachel Nuwer - 30-32 Four game-changing immunology tools to watch
by Gemma Conroy - 777-777 The TrumpRx website won’t slash drug prices — but this will
by Beth Woods - 779-780 Mysterious cosmic ‘dots’ are baffling astronomers. What are they?
by Jenna Ahart - 780-781 Global health is in crisis — who will step in to fix it?
by Fred Schwaller - 782-783 Economics Nobel prize won by researchers who showed how science boosts growth
by Philip Ball - 783-783 First proposed blood test for chronic fatigue syndrome: what scientists think
by David Adam - 784-785 More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys
by Jenna Ahart - 786-786 AI bots wrote and reviewed all papers at this conference
by Elizabeth Gibney - 788-791 Universities are embracing AI: will students get smarter or stop thinking?
by Helen Pearson - 792-794 How to spot fake scientists and stop them from publishing papers
by Miryam Naddaf - 795-796 Why we still don’t understand the Universe — even after a century of dispute
by Helge Kragh - 797-797 Mark Norell obituary: palaeontologist who showed that dinosaurs still walk among us — as birds
by Michael J. Novacek - 799-801 Alternatives to animal testing are the future — it’s time that journals, funders and scientists embrace them
by Todd J. Herron & Anke Brüning-Richardson & Julie E. Gough & Aline F. Miller & Geoffrey J. Pilkington & John Greenman & Valerie Speirs & Joseph C. Wu - 802-803 Why simply ending animal testing isn’t the answer in biomedical research
by K. C. Kent Lloyd - 804-804 Genetics can give evolving societies a leg up
by Andrew J. Doig - 804-804 Take the time to ensure that AI is safe
by Sam Illingworth - 804-804 The race for deep-sea minerals could cause geopolitical and ecological harm
by Milad Haghani & Abbas Rajabifard & Thomas Wiedmann & David A. Hensher - 804-804 Brazil must beef up its COP30 scheme to preserve tropical forests
by James D. Langston & Daniel S. Mendham & Ali Yansyah Abdurrahim & Jatna Supriatna - 805-806 Clues to why the weight-loss condition cachexia arises when cancer occurs
by Kerstin Haase & Mariam Jamal-Hanjani - 806-807 Copper-free chips generate robust ‘combs’ of multicoloured light
by Mher Ghulinyan & Martino Bernard - 808-809 Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing
by Michael Hudecek - 809-811 Is there a ‘smoking gun’ test for quantum gravity?
by Zachary Weller-Davies - 811-812 How a tick-borne virus enters human cells
by Yaw Shin Ooi - 813-817 Classical theories of gravity produce entanglement
by Joseph Aziz & Richard Howl - 831-836 Optimization by decoded quantum interferometry
by Stephen P. Jordan & Noah Shutty & Mary Wootters & Adam Zalcman & Alexander Schmidhuber & Robbie King & Sergei V. Isakov & Tanuj Khattar & Ryan Babbush - 837-842 A metallic p-wave magnet with commensurate spin helix
by Rinsuke Yamada & Max T. Birch & Priya R. Baral & Shun Okumura & Ryota Nakano & Shang Gao & Motohiko Ezawa & Takuya Nomoto & Jan Masell & Yuki Ishihara & Kamil K. Kolincio & Ilya Belopolski & Hajime Sagayama & Hironori Nakao & Kazuki Ohishi & Takashi Ohhara & Ryoji Kiyanagi & Taro Nakajima & Yoshinori Tokura & Taka-hisa Arima & Yukitoshi Motome & Moritz M. Hirschmann & Max Hirschberger - 843-849 Deterministic soliton microcombs in Cu-free photonic integrated circuits
by Xinru Ji & Xurong Li & Zheru Qiu & Rui Ning Wang & Marta Divall & Andrey Gelash & Grigory Lihachev & Tobias J. Kippenberg - 850-855 Cryogenic X-ray photoelectron spectroscopy for battery interfaces
by Sanzeeda Baig Shuchi & Giulio D’Acunto & Philaphon Sayavong & Solomon T. Oyakhire & Kenzie M. Sanroman Gutierrez & Juliet Risner-Jamtgaard & Il Rok Choi & Yi Cui & Stacey F. Bent - 856-864 Modern sea-level rise breaks 4,000-year stability in southeastern China
by Yucheng Lin & Robert E. Kopp & Haixian Xiong & Fiona D. Hibbert & Zhuo Zheng & Fengling Yu & Praveen Kumar & Sönke Dangendorf & Hailin Yi & Yaze Zhang - 865-871 In situ light-field imaging of octopus locomotion reveals simplified control
by Kakani Katija & Christine L. Huffard & Paul L. D. Roberts & Joost Daniels & Jon Erickson & Denis Klimov & Henry A. Ruhl & Alana D. Sherman - 872-882 A compressed hierarchy for visual form processing in the tree shrew
by Frank F. Lanfranchi & Joseph Wekselblatt & Daniel A. Wagenaar & Doris Y. Tsao - 883-892 Rate and noise in human amygdala drive increased exploration in aversive learning
by Tamar Reitich-Stolero & Kristoffer C. Aberg & Dean Halperin & Carmel Ariel & Genela Morris & Lilach Goldstein & Firas Fahoum & Ido Strauss & Rony Paz - 893-902 Human gastroids to model regional patterning in early stomach development
by Xia Li & Feng Lin & Qiqi Cui & Shiyu Sun & Shixin Li & Yue Wang & Yiting Wang & Jianbo Bai & Shiyi Liu & Jia Guo & Yizhao Han & Meiru Zhang & Tie Chang & Yifan Zheng & Jianlin Liu & Longqi Liu & Leyun Wang & Jianping Fu & Xin Liu & Bing Bai & Yue Shao - 903-912 Therapeutic genetic restoration through allogeneic brain microglia replacement
by Marius Marc-Daniel Mader & Alexa Scavetti & Yongjin Yoo & Aaron Tianyue Chai & Takeshi Uenaka & Marius Wernig - 913-924 Microglia–neuron crosstalk through Hex–GM2–MGL2 maintains brain homeostasis
by Maximilian Frosch & Takashi Shimizu & Emile Wogram & Lukas Amann & Lars Gruber & Ayelén I. Groisman & Maximilian Fliegauf & Marius Schwabenland & Chintan Chhatbar & Sabrina Zechel & Hendrik Rosewich & Jutta Gärtner & Francisco J. Quintana & Joerg M. Buescher & Thomas Blank & Harald Binder & Christine Stadelmann & Johannes J. Letzkus & Carsten Hopf & Takahiro Masuda & Klaus-Peter Knobeloch & Marco Prinz - 925-933 Microbial iron oxide respiration coupled to sulfide oxidation
by Song-Can Chen & Xiao-Min Li & Nicola Battisti & Guoqing Guan & Maria A. Montoya & Jay Osvatic & Petra Pjevac & Shaul Pollak & Andreas Richter & Arno Schintlmeister & Wolfgang Wanek & Marc Mussmann & Alexander Loy - 934-944 Dynamic fibroblast–immune interactions shape recovery after brain injury
by Nathan A. Ewing-Crystal & Nicholas M. Mroz & Amara Larpthaveesarp & Carlos O. Lizama & Remy Pennington & Pailin Chiaranunt & Jason I. Dennis & Anthony A. Chang & Eric Dean Merrill & Sofia E. Caryotakis & Nikhita Kirthivasan & Leon Teo & Tatsuya Tsukui & Aditya Katewa & Gabriel L. McKinsey & Sophia C. K. Nelson & Agnieszka Ciesielska & Nicole C. Lummis & Lucija Pintarić & Madelene W. Dahlgren & Amha Atakilit & Helena Paidassi & Saket Jain & Xiaodan Liu & Duan Xu & Manish K. Aghi & James A. Bourne & Jeanne T. Paz & Richard Daneman & Fernando F. Gonzalez & Dean Sheppard & Anna V. Molofsky & Thomas D. Arnold & Ari B. Molofsky - 945-952 LRP8 is a receptor for tick-borne encephalitis virus
by Eva Mittler & Alexandra L. Tse & Pham-Tue-Hung Tran & Catalina Florez & Javier Janer & Renata Varnaite & Ezgi Kasikci & Vasantha Kumar MV & Michaela Loomis & Wanda Christ & Erik Cazares & Russell R. Bakken & Caroline K. Martin & Xiankun Zeng & Jo Lynne Raymond & Mansoureh Shahsavani & Sara Khanal & Eric R. Wilkinson & Rischa Maya Oktavia & Megan M. Slough & Denise Haslwanter & Julianna Han & Jacob Berrigan & Ebba Rosendal & Margaret Kielian & Balaji Manicassamy & Anna K. Överby & Anna Falk & Giovanna Barba-Spaeth & Felix A. Rey & Jonas Klingström & Evripidis Gavathiotis & Andrew S. Herbert & Kartik Chandran & Sara Gredmark-Russ - 953-962 In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma
by Nelson H. Knudsen & Giulia Escobar & Felix Korell & Tamina Kienka & Celeste Nobrega & Seth Anderson & Andrew Y. Cheng & Maria Zschummel & Alexander Armstrong & Amanda Bouffard & Michael C. Kann & Sadie Goncalves & Hans W. Pope & Mitra Pezeshki & Alexander Rojas & Juliette S. M. T. Suermondt & Merle Phillips & Trisha R. Berger & Sangwoo Park & Diego Salas-Benito & Elijah P. Darnell & Filippo Birocchi & Mark B. Leick & Rebecca C. Larson & John G. Doench & Debattama Sen & Kathleen B. Yates & Robert T. Manguso & Marcela V. Maus - 963-972 Systematic discovery of CRISPR-boosted CAR T cell immunotherapies
by Paul Datlinger & Eugenia V. Pankevich & Cosmas D. Arnold & Nicole Pranckevicius & Jenny Lin & Daria Romanovskaia & Moritz Schaefer & Francesco Piras & Anne-Christine Orts & Amelie Nemc & Paulina N. Biesaga & Michelle Chan & Teresa Neuwirth & Artem V. Artemov & Wentao Li & Sabrina Ladstätter & Thomas Krausgruber & Christoph Bock - 973-982 Molecular subtypes of human skeletal muscle in cancer cachexia
by Bhumi J. Bhatt & Sunita Ghosh & Vera Mazurak & Aurélien Q. Brun & Oliver Bathe & Vickie E. Baracos & Sambasivarao Damaraju - 983-991 CRISPR activation for SCN2A-related neurodevelopmental disorders
by Serena Tamura & Andrew D. Nelson & Perry W. E. Spratt & Elizabeth C. Hamada & Xujia Zhou & Henry Kyoung & Zizheng Li & Coline Arnould & Vladyslav Barskyi & Beniamin Krupkin & Kiana Young & Jingjing Zhao & Stephanie S. Holden & Atehsa Sahagun & Caroline M. Keeshen & Congyi Lu & Roy Ben-Shalom & Sunrae E. Taloma & Selin Schamiloglu & Ying C. Li & Lia Min & Paul M. Jenkins & Jen Q. Pan & Jeanne T. Paz & Stephan J. Sanders & Navneet Matharu & Nadav Ahituv & Kevin J. Bender - 992-1000 DNA2 enables growth by restricting recombination-restarted replication
by Jessica J. R. Hudson & Rowin Appanah & David Jones & Kathryn Davidson & Alice M. Budden & Alina Vaitsiankova & Kok-Lung Chan & Keith W. Caldecott & Antony M. Carr & Ulrich Rass - 1001-1011 Multiple overlapping binding sites determine transcription factor occupancy
by Shubham Khetan & Brent S. Carroll & Martha L. Bulyk - 1013-1016 Are these the happiest PhD students in the world?
by Linda Nordling - 1018-1018 Cold plunge: how I gained hands-on experience in marine biology
by Nikki Forrester
October 2025, Volume 646, Issue 8085
- 517-517 How journals can break down barriers for Latin American scientists
by Mariana Viglino - 518-518 Inside our university’s mission to pivot to research
by Doreen Ramogola-Masire - 521-522 Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
by Miryam Naddaf & Elizabeth Gibney - 522-523 Chemistry Nobel for scientists who developed massively porous ‘super sponge’ materials
by Davide Castelvecchi & Miryam Naddaf - 523-524 Groundbreaking quantum-tunnelling experiments win physics Nobel
by Elizabeth Gibney & Davide Castelvecchi - 524-525 Creative hobbies could slow brain ageing at the molecular level
by Gemma Conroy - 525-525 First human transplant of kidney modified to have ‘universal’ blood type
by Rachel Fieldhouse - 526-527 The rise of ‘nightmare bacteria’: antimicrobial resistance in five charts
by Katie Kavanagh - 528-528 ‘Google for DNA’ brings order to biology’s big data
by Elie Dolgin - 530-532 Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier
by Gemma Conroy - 534-536 The quest to make babies with lab-grown eggs and sperm
by Heidi Ledford - 537-538 Alchemy: discredited pseudoscience or chemistry’s worthy ancestor?
by Kit Chapman - 539-540 The race to uncover snow’s many mysteries before it disappears forever
by Gareth Thompson - 541-541 Jane Goodall obituary: pioneer primatologist who inspired generations of scientists
by Richard Wrangham - 543-546 Carbon credits are failing to help with climate change — here’s why
by Andrew Macintosh & Gregory Trencher & Benedict Probst & Shanta Barley & Danny Cullenward & Thales A. P. West & Don Butler & Johan Rockström - 547-549 Metals are key to the global economy — but three challenges threaten supply chains
by Tarasankar DebRoy & Todd A. Palmer & John W. Elmer & Tuhin Mukherjee - 550-550 AI’s therapeutic potential goes beyond emotional connection
by Elad Refoua & Eshkol Rafaeli & Dorit Hadar Shoval - 550-550 Brazil’s COP30 legacy should be to protect more of its forests
by Paulo Moutinho & André Guimarães - 550-550 Longer grant cycles would boost research in Africa
by Fulufhelo Nemavhola - 550-550 Red lines for religious AI
by Max Tretter & Anna Puzio - 551-552 Ion stencils used for synthesis of patchy nanoparticles
by Ilona Kretzschmar & Emanuela Bianchi - 552-554 Flies evolved a shock-absorber tissue used during embryonic development
by Thibaut Brunet - 554-554 Birds’ intruder alert hints at how sounds took on new meanings
by Holly Smith - 555-556 Extreme confinement unleashes water’s hidden electrical capabilities
by Neus Domingo & Albert Verdaguer - 556-558 Caribbean coral reefs are threatened by rising seas
by Nicola K. Browne - 558-559 A drug–diet combination could improve childhood cancer treatment
by Frank Speleman & Louis Delhaye - 561-566 Efficient quantum thermal simulation
by Chi-Fang Chen & Michael Kastoryano & Fernando G. S. L. Brandão & András Gilyén - 567-575 Integrated lithium niobate photonics for sub-ångström snapshot spectroscopy
by Zhiyang Yao & Shuyang Liu & Yingce Wang & Xiaoyun Yuan & Lu Fang - 576-583 Proximal cooperative aerial manipulation with vertically stacked drones
by Huazi Cao & Jiahao Shen & Yin Zhang & Zheng Fu & Cunjia Liu & Sihao Sun & Shiyu Zhao - 584-591 Long-distance remote epitaxy
by Ru Jia & Yan Xin & Mark Potter & Jie Jiang & Zixu Wang & Hanxue Ma & Zhihao Zhang & Zhizhuo Liang & Lifu Zhang & Zonghuan Lu & Ruizhe Yang & Saloni Pendse & Yang Hu & Kai Peng & Yilin Meng & Wei Bao & Jun Liu & Gwo-Ching Wang & Toh-Ming Lu & Yunfeng Shi & Hanwei Gao & Jian Shi - 592-600 Patchy nanoparticles by atomic stencilling
by Ahyoung Kim & Chansong Kim & Tommy Waltmann & Thi Vo & Eun Mi Kim & Junseok Kim & Yu-Tsun Shao & Aaron Michelson & John R. Crockett & Falon C. Kalutantirige & Eric Yang & Lehan Yao & Chu-Yun Hwang & Yugang Zhang & Yu-Shen Liu & Hyosung An & Zirui Gao & Jiyeon Kim & Sohini Mandal & David A. Muller & Kristen A. Fichthorn & Sharon C. Glotzer & Qian Chen - 601-605 Marcus kinetics control singlet and triplet oxygen evolving from superoxide
by Soumyadip Mondal & Huyen T. K. Nguyen & Robert Hauschild & Stefan A. Freunberger - 606-610 In-plane dielectric constant and conductivity of confined water
by R. Wang & M. Souilamas & A. Esfandiar & R. Fabregas & S. Benaglia & H. Nevison-Andrews & Q. Yang & J. Normansell & P. Ares & G. Ferrari & A. Principi & A. K. Geim & L. Fumagalli - 611-618 Aboveground biomass in Australian tropical forests now a net carbon source
by Hannah Carle & David Bauman & Michael N. Evans & Ingrid Coughlin & Oliver Binks & Andrew Ford & Matthew Bradford & Adrienne Nicotra & Helen Murphy & Patrick Meir - 619-626 Reduced Atlantic reef growth past 2 °C warming amplifies sea-level impacts
by Chris T. Perry & Didier M. Bakker & Alice E. Webb & Steeve Comeau & Ben P. Harvey & Christopher E. Cornwall & Lorenzo Alvarez-Filip & Esmeralda Pérez-Cervantes & John Morris & Ian C. Enochs & Lauren T. Toth & Aaron O’Dea & Erin M. Dillon & Erik H. Meesters & William F. Precht - 627-636 Patterned invagination prevents mechanical instability during gastrulation
by Bruno C. Vellutini & Marina B. Cuenca & Abhijeet Krishna & Alicja Szałapak & Carl D. Modes & Pavel Tomancak - 637-646 Divergent evolutionary strategies pre-empt tissue collision in gastrulation
by Bipasha Dey & Verena Kaul & Girish Kale & Maily Scorcelletti & Michiko Takeda & Yu-Chiun Wang & Steffen Lemke - 647-656 Parent-of-origin effects on complex traits in up to 236,781 individuals
by Robin J. Hofmeister & Théo Cavinato & Roya Karimi & Adriaan Graaf & Fanny-Dhelia Pajuste & Jaanika Kronberg & Nele Taba & Reedik Mägi & Marc Vaudel & Simone Rubinacci & Stefan Johansson & Lili Milani & Olivier Delaneau & Zoltán Kutalik - 657-666 Single-cell transcriptomic and genomic changes in the ageing human brain
by Ailsa M. Jeffries & Tianxiong Yu & Jennifer S. Ziegenfuss & Allie K. Tolles & Christina E. Baer & Cesar Bautista Sotelo & Yerin Kim & Zhiping Weng & Michael A. Lodato - 667-675 Network synchrony creates neural filters promoting quiescence in Drosophila
by Davide Raccuglia & Raquel Suárez-Grimalt & Laura Krumm & Anatoli Ender & Cédric B. Brodersen & Sridhar R. Jagannathan & Martin Freire Krück & Niccolò P. Pampaloni & Carolin Rauch & York Winter & Genevieve Yvon-Durocher & Richard Kempter & Jörg R. P. Geiger & David Owald - 676-686 Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
by Diankun Yu & Samhita Jain & Andi Wangzhou & Beika Zhu & Wenyuan Shao & Elena J. Coley-O’Rourke & Stacy Florencio & JaeYeon Kim & Jennifer Ja-Yoon Choi & Mercedes F. Paredes & Tomasz J. Nowakowski & Eric J. Huang & Xianhua Piao - 687-696 Haematopoietic stem cell number is not solely defined by niche availability
by Shoichiro Takeishi & Tony Marchand & Wade R. Koba & Daniel K. Borger & Chunliang Xu & Chandan Guha & Aviv Bergman & Paul S. Frenette & Kira Gritsman & Ulrich Steidl - 697-706 Amygdala–liver signalling orchestrates glycaemic responses to stress
by J. R. E. Carty & K. Devarakonda & R. M. O’Connor & A. Krek & D. Espinoza & M. Jimenez-Gonzalez & A. Alvarsson & R. F. Hampton & R. Li & Y. Qiu & S. Petri & A. Shtekler & A. Rajbhandari & K. Conner & M. Bayne & D. Garibay & J. Martin & V. Lehmann & L. Wang & K. Beaumont & I. Kurland & G. C. Yuan & P. J. Kenny & S. A. Stanley - 707-715 Reprogramming neuroblastoma by diet-enhanced polyamine depletion
by Sarah Cherkaoui & Christina S. Turn & Yuan Yuan & Wenyun Lu & Lifeng Yang & Matthew J. McBride & Caroline Eigenmann & George E. Allen & Olesya O. Panasenko & Lu Zhang & Annette Vu & Kangning Liu & Yimei Li & Om H. Gandhi & Lea F. Surrey & Sandra D. Kienast & Sebastian A. Leidel & Michael Wierer & Eileen White & Joshua D. Rabinowitz & Michael D. Hogarty & Raphael J. Morscher - 716-723 The Virtual Lab of AI agents designs new SARS-CoV-2 nanobodies
by Kyle Swanson & Wesley Wu & Nash L. Bulaong & John E. Pak & James Zou - 724-733 Thymic epithelial cells amplify epigenetic noise to promote immune tolerance
by Noah Gamble & Jason A. Caldwell & Joshua McKeever & Caroline Kaiser & Alexandra Bradu & Peyton J. Dooley & Sandy Klemm & William J. Greenleaf & Narutoshi Hibino & Aaron R. Dinner & Andrew S. Koh - 734-745 Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors
by Shilpa Singh & Catherine E. Gleason & Min Fang & Yasmin N. Laimon & Vishal Khivansara & Shanhai Xie & Yavuz T. Durmaz & Aniruddha Sarkar & Kenneth Ngo & Varunika Savla & Yixiang Li & Muhannad Abu-Remaileh & Xinyue Li & Marie-Anais Locquet & Bishma Tuladhar & Ranya Odeh & Frances Hamkins-Indik & Daphne He & Miles W. Membreno & Meisam Nosrati & Nathan N. Gushwa & Siegfried S. F. Leung & Breena Fraga-Walton & Luis Hernandez & Miguel P. Baldomero & Bryan M. Lent & David Spellmeyer & Joshua F. Luna & Dalena Hoang & Yuliana Gritsenko & Manesh Chand & Megan K. DeMart & Sammy Metobo & Chinmay Bhatt & Justin A. Shapiro & Kai Yang & Nathan J. Dupper & Andrew T. Bockus & Jinshu Fang & Ramesh Bambal & Peadar Cremin & John G. Doench & James B. Aggen & Li-Fen Liu & Bernard Levin & Evelyn W. Wang & Iolanda Vendrell & Roman Fischer & Benedikt Kessler & Prafulla C. Gokhale & Sabina Signoretti & Alexander Spektor & Constantine Kreatsoulas & Marie Evangelista & Rajinder Singh & David J. Earp & Deepak Nijhawan & Pablo D. Garcia & Matthew G. Oser - 746-753 Cocaine chemogenetics blunts drug-seeking by synthetic physiology
by Juan L. Gomez & Christopher J. Magnus & Jordi Bonaventura & Oscar Solis & Fallon P. Curry & Marjorie R. Levinstein & Reece C. Budinich & Meghan L. Carlton & Emilya N. Ventriglia & Sherry Lam & Le Wang & Ingrid Schoenborn & William Dunne & Michael Michaelides & Scott M. Sternson - 754-758 Crystal structures of agonist-bound human cannabinoid receptor CB1
by Tian Hua & Kiran Vemuri & Spyros P. Nikas & Yiran Wu & Lu Qu & Mengchen Pu & Anisha Korde & Shan Jiang & Jo-Hao Ho & Gye Won Han & Kang Ding & Xuanxuan Li & Haiguang Liu & Michael A. Hanson & Suwen Zhao & Laura M. Bohn & Alexandros Makriyannis & Raymond C. Stevens & Zhi-Jie Liu - 759-762 Research assessment: a round-up for early-career researchers
by Holly Else - 763-765 Digital flocks, predators allow ecologists to simulate real-world animal behaviour
by Heather Richardson - 768-768 Defending Ohuira Bay, Mexico
by Rachael Pells
October 2025, Volume 646, Issue 8084
- 261-261 Prizes must recognize machine contributions to discovery
by Dashun Wang - 263-264 US serial killer case opens door to using cutting-edge DNA data in courts
by Katherine Bourzac - 264-266 NIH races to spend its 2025 grant money — but fewer projects win funding
by Max Kozlov - 266-267 China pledges to cut emissions by 2035: what does that mean for the climate?
by Xiaoying You - 267-268 Swapping old immune cells in the brain with fresh ones could treat disease
by Heidi Ledford - 268-269 Will your study change the world? This AI tool predicts the impact of your research
by Brian Owens - 269-270 Want to do disruptive science? Include more rookie researchers
by Katie Kavanagh - 270-270 See space fireworks and lightning spaghetti — September’s best science images
by Fred Schwaller & Katie Kavanagh - 272-275 AI models that lie, cheat and plot murder: how dangerous are LLMs really?
by Matthew Hutson - 276-278 Will AI ever win its own Nobel? Some predict a prize-worthy science discovery soon
by Jenna Ahart - 279-280 From fossil fuels to ‘green capitalism’: the dilemmas of a just energy transition
by Sophia Kalantzakos - 281-283 The cutting-edge medical approaches that could transform ageing
by Coleen T. Murphy - 283-283 Violin therapy: Books in brief
by Andrew Robinson - 284-286 Stop treating code like an afterthought: record, share and value it
by Roberto Di Cosmo & Sabrina Granger & Konrad Hinsen & Nicolas Jullien & Daniel Le Berre & Violaine Louvet & Camille Maumet & Clémentine Maurice & Raphaël Monat & Nicolas P. Rougier - 286-287 Customizable AI systems that anyone can adapt bring big opportunities — and even bigger risks
by Yarin Gal & Stephen Casper