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Gene x Environment Interactions: Polygenic Scores and the Impact of an Early Childhood Intervention in Colombia

Author

Listed:
  • Orazio Attanasio
  • Gabriella Conti
  • Pamela Jervis
  • Costas Meghir
  • Aysu Okbay

Abstract

We evaluate impacts heterogeneity of an Early Childhood Intervention, with respect to the Educational Attainment Polygenic Score (EA4 PGS) constructed from DNA data based on GWAS weights from a European population. We find that the EA4 PGS is predictive of several measures of child development, mother’s IQ and, to some extent, educational attainment. We also show that the impacts of the intervention are significantly greater in children with low PGS, to the point that the intervention eliminates the initial genetic disadvantage. Lastly, we find that children with high PGS attract more parental stimulation; however, the latter increases more strongly in children with low PGS.

Suggested Citation

  • Orazio Attanasio & Gabriella Conti & Pamela Jervis & Costas Meghir & Aysu Okbay, 2025. "Gene x Environment Interactions: Polygenic Scores and the Impact of an Early Childhood Intervention in Colombia," NBER Working Papers 33781, National Bureau of Economic Research, Inc.
    • Handle: RePEc:nbr:nberwo:33781
    Note: CH PE
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    JEL classification:

    • I24 - Health, Education, and Welfare - - Education - - - Education and Inequality
    • I26 - Health, Education, and Welfare - - Education - - - Returns to Education
    • I3 - Health, Education, and Welfare - - Welfare, Well-Being, and Poverty
    • I38 - Health, Education, and Welfare - - Welfare, Well-Being, and Poverty - - - Government Programs; Provision and Effects of Welfare Programs
    • O15 - Economic Development, Innovation, Technological Change, and Growth - - Economic Development - - - Economic Development: Human Resources; Human Development; Income Distribution; Migration

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