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Cost-Utility Analysis of a Dolutegravir-Based Versus Low-Dose Efavirenz-Based Regimen for the Initial Treatment of HIV-Infected Patients in Cameroon (NAMSAL ANRS 12313 Trial)

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  • Marwân-Al-Qays Bousmah

    (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale - IRD - Institut de Recherche pour le Développement - AMU - Aix Marseille Université - INSERM - Institut National de la Santé et de la Recherche Médicale, CEPED - UMR_D 196 - Centre population et développement - IRD - Institut de Recherche pour le Développement - UPCité - Université Paris Cité)

  • Marie Libérée Nishimwe

    (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale - IRD - Institut de Recherche pour le Développement - AMU - Aix Marseille Université - INSERM - Institut National de la Santé et de la Recherche Médicale, ORS PACA - Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille])

  • Tamara Tovar-Sanchez

    (TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes - IRD - Institut de Recherche pour le Développement - UY1 - Université de Yaoundé I - INSERM - Institut National de la Santé et de la Recherche Médicale - UM - Université de Montpellier - UCAD - Université Cheikh Anta Diop de Dakar [Sénégal], CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier])

  • Martial Lantche Wandji

    (ANRS - Agence Nationale de Recherches sur le Sida et les Hépatites Virales, Hôpital Central de Yaoundé [Yaoundé])

  • Mireille Mpoudi-Etame

    (Hôpital Militaire de Yaoundé - Partenaires INRAE)

  • Gwenaëlle Maradan

    (ORS PACA - Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille])

  • Pierrette Omgba Bassega

    (Hôpital de la Cité Verte [Yaoundé])

  • Marie Varloteaux

    (ANRS - Agence Nationale de Recherches sur le Sida et les Hépatites Virales, Hôpital Central de Yaoundé [Yaoundé])

  • Alice Montoyo

    (ANRS - Agence Nationale de Recherches sur le Sida et les Hépatites Virales)

  • Charles Kouanfack

    (ANRS - Agence Nationale de Recherches sur le Sida et les Hépatites Virales, Hôpital Central de Yaoundé [Yaoundé], Université de Dshang)

  • Eric Delaporte

    (TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes - IRD - Institut de Recherche pour le Développement - UY1 - Université de Yaoundé I - INSERM - Institut National de la Santé et de la Recherche Médicale - UM - Université de Montpellier - UCAD - Université Cheikh Anta Diop de Dakar [Sénégal], CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier])

  • Sylvie Boyer

    (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale - IRD - Institut de Recherche pour le Développement - AMU - Aix Marseille Université - INSERM - Institut National de la Santé et de la Recherche Médicale)

Abstract

Objectives: Evidence comparing the economic and patient values of the World Health Organization's preferred (dolutegravir 50 mg [DTG]-based) and alternative (low-dose [400 mg] efavirenz [EFV400]-based) first-line antiretroviral regimens is limited. We compared patient-reported outcomes (PROs), costs, and the cost-utility of DTG- versus EFV400-based regimens in treatment-naive HIV-1 adults in the randomised NAMSAL ANRS 12313 trial in Yaoundé, Cameroon. Methods: We used clinical data, PROs, and health resource use data collected in the trial's first 96 weeks (2016–2019). Quality-adjusted life-years (QALYs) were computed using utility scores obtained from the 12-item Short Form (SF-12) generic health scale. Other PROs included perceived symptoms, depression, anxiety, and stress. In the 96-week base-case analysis, we estimated the unadjusted and multivariate-adjusted (1) mean costs (in US$, 2016 values) and QALYs/patient, (2) incremental costs and QALYs/patient, and (3) net health benefit (NHB). Outcomes were extrapolated over 5 and 10 years. Uncertainty was assessed using the cost-effectiveness acceptability curve and scenario and cost-effective price threshold analyses.

Suggested Citation

  • Marwân-Al-Qays Bousmah & Marie Libérée Nishimwe & Tamara Tovar-Sanchez & Martial Lantche Wandji & Mireille Mpoudi-Etame & Gwenaëlle Maradan & Pierrette Omgba Bassega & Marie Varloteaux & Alice Montoyo, 2021. "Cost-Utility Analysis of a Dolutegravir-Based Versus Low-Dose Efavirenz-Based Regimen for the Initial Treatment of HIV-Infected Patients in Cameroon (NAMSAL ANRS 12313 Trial)," Post-Print hal-03174666, HAL.
  • Handle: RePEc:hal:journl:hal-03174666
    DOI: 10.1007/s40273-020-00987-3
    Note: View the original document on HAL open archive server: https://hal.umontpellier.fr/hal-03174666
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    References listed on IDEAS

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    1. Glick, Henry A. & Doshi, Jalpa A. & Sonnad, Seema S. & Polsky, Daniel, 2014. "Economic Evaluation in Clinical Trials," OUP Catalogue, Oxford University Press, edition 2, number 9780199685028, Decembrie.
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    1. Journal round-up: PharmacoEconomics 39(3)
      by Chris Sampson in The Academic Health Economists' Blog on 2021-04-05 06:00:12

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