IDEAS home Printed from https://ideas.repec.org/a/wly/riskan/v35y2015i5p811-827.html
   My bibliography  Save this article

Evaluation of Inhaled Versus Deposited Dose Using the Exponential Dose‐Response Model for Inhalational Anthrax in Nonhuman Primate, Rabbit, and Guinea Pig

Author

Listed:
  • Bradford W. Gutting
  • Andrey Rukhin
  • Ryan S. Mackie
  • David Marchette
  • Brandolyn Thran

Abstract

The application of the exponential model is extended by the inclusion of new nonhuman primate (NHP), rabbit, and guinea pig dose‐lethality data for inhalation anthrax. Because deposition is a critical step in the initiation of inhalation anthrax, inhaled doses may not provide the most accurate cross‐species comparison. For this reason, species‐specific deposition factors were derived to translate inhaled dose to deposited dose. Four NHP, three rabbit, and two guinea pig data sets were utilized. Results from species‐specific pooling analysis suggested all four NHP data sets could be pooled into a single NHP data set, which was also true for the rabbit and guinea pig data sets. The three species‐specific pooled data sets could not be combined into a single generic mammalian data set. For inhaled dose, NHPs were the most sensitive (relative lowest LD50) species and rabbits the least. Improved inhaled LD50s proposed for use in risk assessment are 50,600, 102,600, and 70,800 inhaled spores for NHP, rabbit, and guinea pig, respectively. Lung deposition factors were estimated for each species using published deposition data from Bacillus spore exposures, particle deposition studies, and computer modeling. Deposition was estimated at 22%, 9%, and 30% of the inhaled dose for NHP, rabbit, and guinea pig, respectively. When the inhaled dose was adjusted to reflect deposited dose, the rabbit animal model appears the most sensitive with the guinea pig the least sensitive species.

Suggested Citation

  • Bradford W. Gutting & Andrey Rukhin & Ryan S. Mackie & David Marchette & Brandolyn Thran, 2015. "Evaluation of Inhaled Versus Deposited Dose Using the Exponential Dose‐Response Model for Inhalational Anthrax in Nonhuman Primate, Rabbit, and Guinea Pig," Risk Analysis, John Wiley & Sons, vol. 35(5), pages 811-827, May.
    • Handle: RePEc:wly:riskan:v:35:y:2015:i:5:p:811-827
    DOI: 10.1111/risa.12326
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/risa.12326
    Download Restriction: no
    File URL: https://libkey.io/10.1111/risa.12326?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sarah C. Taft & Stephanie A. Hines, 2012. "Benchmark Dose Analysis for Bacillus anthracis Inhalation Exposures in the Nonhuman Primate," Risk Analysis, John Wiley & Sons, vol. 32(10), pages 1750-1768, October.
    2. Timothy A. Bartrand & Mark H. Weir & Charles N. Haas, 2008. "Dose‐Response Models for Inhalation of Bacillus anthracis Spores: Interspecies Comparisons," Risk Analysis, John Wiley & Sons, vol. 28(4), pages 1115-1124, August.
    3. Charles N. Haas & Joan B. Rose & Charles Gerba & Stig Regli, 1993. "Risk Assessment of Virus in Drinking Water," Risk Analysis, John Wiley & Sons, vol. 13(5), pages 545-552, October.
    4. Dean A. Wilkening, 2008. "Modeling the Incubation Period of Inhalational Anthrax," Medical Decision Making, , vol. 28(4), pages 593-605, July.
    5. Damon J A Toth & Adi V Gundlapalli & Wiley A Schell & Kenneth Bulmahn & Thomas E Walton & Christopher W Woods & Catherine Coghill & Frank Gallegos & Matthew H Samore & Frederick R Adler, 2013. "Quantitative Models of the Dose-Response and Time Course of Inhalational Anthrax in Humans," PLOS Pathogens, Public Library of Science, vol. 9(8), pages 1-18, August.
    6. Charles N. Haas, 2002. "On the Risk of Mortality to Primates Exposed to Anthrax Spores," Risk Analysis, John Wiley & Sons, vol. 22(2), pages 189-193, April.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Bradford W. Gutting & Andrey Rukhin & David Marchette & Ryan S. Mackie & Brandolyn Thran, 2016. "Dose‐Response Modeling for Inhalational Anthrax in Rabbits Following Single or Multiple Exposures," Risk Analysis, John Wiley & Sons, vol. 36(11), pages 2031-2038, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Damon J A Toth & Adi V Gundlapalli & Wiley A Schell & Kenneth Bulmahn & Thomas E Walton & Christopher W Woods & Catherine Coghill & Frank Gallegos & Matthew H Samore & Frederick R Adler, 2013. "Quantitative Models of the Dose-Response and Time Course of Inhalational Anthrax in Humans," PLOS Pathogens, Public Library of Science, vol. 9(8), pages 1-18, August.
    2. Margaret E. Coleman & Harry M. Marks & Timothy A. Bartrand & Darrell W. Donahue & Stephanie A. Hines & Jason E. Comer & Sarah C. Taft, 2017. "Modeling Rabbit Responses to Single and Multiple Aerosol Exposures of Bacillus anthracis Spores," Risk Analysis, John Wiley & Sons, vol. 37(5), pages 943-957, May.
    3. Bradford W. Gutting & Andrey Rukhin & David Marchette & Ryan S. Mackie & Brandolyn Thran, 2016. "Dose‐Response Modeling for Inhalational Anthrax in Rabbits Following Single or Multiple Exposures," Risk Analysis, John Wiley & Sons, vol. 36(11), pages 2031-2038, November.
    4. Tao Hong & Patrick L. Gurian & Nicholas F. Dudley Ward, 2010. "Setting Risk‐Informed Environmental Standards for Bacillus Anthracis Spores," Risk Analysis, John Wiley & Sons, vol. 30(10), pages 1602-1622, October.
    5. Sarah C. Taft & Stephanie A. Hines, 2012. "Benchmark Dose Analysis for Bacillus anthracis Inhalation Exposures in the Nonhuman Primate," Risk Analysis, John Wiley & Sons, vol. 32(10), pages 1750-1768, October.
    6. Michael A. Hamilton & Tao Hong & Elizabeth Casman & Patrick L. Gurian, 2015. "Risk‐Based Decision Making for Reoccupation of Contaminated Areas Following a Wide‐Area Anthrax Release," Risk Analysis, John Wiley & Sons, vol. 35(7), pages 1348-1363, July.
    7. Michael Greenberg & Charles Haas & Anthony Cox & Karen Lowrie & Katherine McComas & Warner North, 2012. "Ten Most Important Accomplishments in Risk Analysis, 1980–2010," Risk Analysis, John Wiley & Sons, vol. 32(5), pages 771-781, May.
    8. David Simchi-Levi & Nikolaos Trichakis & Peter Yun Zhang, 2019. "Designing Response Supply Chain Against Bioattacks," Operations Research, INFORMS, vol. 67(5), pages 1246-1268, September.
    9. Hamilton, Andrew J. & Boland, Anne-Maree & Stevens, Daryl & Kelly, Jim & Radcliffe, John & Ziehrl, Angelika & Dillon, Peter & Paulin, Bob, 2005. "Position of the Australian horticultural industry with respect to the use of reclaimed water," Agricultural Water Management, Elsevier, vol. 71(3), pages 181-209, February.
    10. Laura X. Henao‐Herreño & Ana M. López‐Tamayo & Juan P. Ramos‐Bonilla & Charles N. Haas & Johana Husserl, 2017. "Risk of Illness with Salmonella due to Consumption of Raw Unwashed Vegetables Irrigated with Water from the Bogotá River," Risk Analysis, John Wiley & Sons, vol. 37(4), pages 733-743, April.
    11. Judith Legrand & Joseph R Egan & Ian M Hall & Simon Cauchemez & Steve Leach & Neil M Ferguson, 2009. "Estimating the Location and Spatial Extent of a Covert Anthrax Release," PLOS Computational Biology, Public Library of Science, vol. 5(1), pages 1-9, April.
    12. Philip J. Schmidt & Katarina D. M. Pintar & Aamir M. Fazil & Edward Topp, 2013. "Harnessing the Theoretical Foundations of the Exponential and Beta‐Poisson Dose‐Response Models to Quantify Parameter Uncertainty Using Markov Chain Monte Carlo," Risk Analysis, John Wiley & Sons, vol. 33(9), pages 1677-1693, September.
    13. Signe M. Jensen & Christian Ritz, 2015. "Simultaneous Inference for Model Averaging of Derived Parameters," Risk Analysis, John Wiley & Sons, vol. 35(1), pages 68-76, January.
    14. Hetty Blaak & Gretta Lynch & Ronald Italiaander & Raditijo A Hamidjaja & Franciska M Schets & Ana Maria de Roda Husman, 2015. "Multidrug-Resistant and Extended Spectrum Beta-Lactamase-Producing Escherichia coli in Dutch Surface Water and Wastewater," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-16, June.
    15. Tucker Burch, 2019. "Validation of Quantitative Microbial Risk Assessment Using Epidemiological Data from Outbreaks of Waterborne Gastrointestinal Disease," Risk Analysis, John Wiley & Sons, vol. 39(3), pages 599-615, March.
    16. Margaret L. Brandeau, 2019. "OR Forum—Public Health Preparedness: Answering (Largely Unanswerable) Questions with Operations Research—The 2016–2017 Philip McCord Morse Lecture," Operations Research, INFORMS, vol. 67(3), pages 700-710, May.
    17. Joseph Shingleton & David Mustard & Steven Dyke & Hannah Williams & Emma Bennett & Thomas Finnie, 2024. "Backtracking: Improved methods for identifying the source of a deliberate release of Bacillus anthracis from the temporal and spatial distribution of cases," PLOS Computational Biology, Public Library of Science, vol. 20(9), pages 1-18, September.
    18. S. R. Petterson, 2016. "Application of a QMRA Framework to Inform Selection of Drinking Water Interventions in the Developing Context," Risk Analysis, John Wiley & Sons, vol. 36(2), pages 203-214, February.
    19. Charles N. Haas, 2002. "On the Risk of Mortality to Primates Exposed to Anthrax Spores," Risk Analysis, John Wiley & Sons, vol. 22(2), pages 189-193, April.
    20. John L. Cicmanec, 2002. "Letter to the Editor from Cicmanec," Risk Analysis, John Wiley & Sons, vol. 22(6), pages 1035-1036, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:wly:riskan:v:35:y:2015:i:5:p:811-827. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: https://doi.org/10.1111/(ISSN)1539-6924 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.