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Relation Between Benchmark Dose and No‐Observed‐Adverse‐Effect Level in Clinical Research: Effects of Daily Alcohol Intake on Blood Pressure in Japanese Salesmen

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  • Miwako Dakeishi
  • Katsuyuki Murata
  • Akiko Tamura
  • Toyoto Iwata

Abstract

The benchmark dose (BMD) is defined as the dose that corresponds to a specific change in an adverse response compared to the response in unexposed subjects, and the lower 95% confidence limit is termed the benchmark dose level (BMDL). In this study, the threshold of daily ethanol intake affecting blood pressure was calculated by both the BMD approach and multiple logistic regression analysis to clarify the relation between the BMDL and no‐observed‐adverse‐effect level (NOAEL). Systolic and diastolic blood pressures (SBP and DBP) and daily ethanol intake were explored in 1,100 Japanese salesmen. The SBP and DBP were positively related to daily ethanol intake (p

Suggested Citation

  • Miwako Dakeishi & Katsuyuki Murata & Akiko Tamura & Toyoto Iwata, 2006. "Relation Between Benchmark Dose and No‐Observed‐Adverse‐Effect Level in Clinical Research: Effects of Daily Alcohol Intake on Blood Pressure in Japanese Salesmen," Risk Analysis, John Wiley & Sons, vol. 26(1), pages 115-123, February.
    • Handle: RePEc:wly:riskan:v:26:y:2006:i:1:p:115-123
    DOI: 10.1111/j.1539-6924.2006.00722.x
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    References listed on IDEAS

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    1. R. Webster West & Ralph L. Kodell, 1999. "A Comparison of Methods of Benchmark‐Dose Estimation for Continuous Response Data," Risk Analysis, John Wiley & Sons, vol. 19(3), pages 453-459, June.
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    4. Katsuyuki Murata & Esben Budtz‐Jørgensen & Philippe Grandjean, 2002. "Benchmark Dose Calculations for Methylmercury‐Associated Delays on Evoked Potential Latencies in Two Cohorts of Children," Risk Analysis, John Wiley & Sons, vol. 22(3), pages 465-474, June.
    5. Esben Budtz-Jørgensen & Niels Keiding & Philippe Grandjean, 2001. "Benchmark Dose Calculation from Epidemiological Data," Biometrics, The International Biometric Society, vol. 57(3), pages 698-706, September.
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    Cited by:

    1. Noelle Liao & Edmund Seto & Brenda Eskenazi & May Wang & Yan Li & Jenna Hua, 2018. "A Comprehensive Review of Arsenic Exposure and Risk from Rice and a Risk Assessment among a Cohort of Adolescents in Kunming, China," IJERPH, MDPI, vol. 15(10), pages 1-17, October.
    2. Yasushi Suwazono & Kouichi Sakata & Mitsuhiro Oishi & Yasushi Okubo & Mirei Dochi & Etsuko Kobayashi & Teruhiko Kido & Koji Nogawa, 2007. "Estimation of Benchmark Dose as the Threshold Amount of Alcohol Consumption for Blood Pressure in Japanese Workers," Risk Analysis, John Wiley & Sons, vol. 27(6), pages 1487-1495, December.

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