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Experimental Closed‐Loop Control of Breast Cancer in Mice

Author

Listed:
  • Levente Kovács
  • Bence Czakó
  • Máté Siket
  • Tamás Ferenci
  • András Füredi
  • Balázs Gombos
  • Gergely Szakács
  • Dániel András Drexler

Abstract

Cancer therapy optimization is an issue that can be solved using the control engineering approach. An optimal therapy generation algorithm is presented and tested using a tractable mouse model of breast cancer. The optimized therapeutic protocol is calculated in a closed‐loop manner at fixed time instants, twice in a week. The controller consists of a nonlinear model predictive controller which uses the state estimation of a moving horizon estimator. The estimator also computes parameter estimates of the prediction model such that the time varying nature of tumor evolution can be captured. Results show that remission can be induced in a 28‐day interval using the algorithm.

Suggested Citation

  • Levente Kovács & Bence Czakó & Máté Siket & Tamás Ferenci & András Füredi & Balázs Gombos & Gergely Szakács & Dániel András Drexler, 2022. "Experimental Closed‐Loop Control of Breast Cancer in Mice," Complexity, John Wiley & Sons, vol. 2022(1).
    • Handle: RePEc:wly:complx:v:2022:y:2022:i:1:n:9348166
    DOI: 10.1155/2022/9348166
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    References listed on IDEAS

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    1. Rihan, F.A. & Lakshmanan, S. & Maurer, H., 2019. "Optimal control of tumour-immune model with time-delay and immuno-chemotherapy," Applied Mathematics and Computation, Elsevier, vol. 353(C), pages 147-165.
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