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Biomechanics in bone tissue engineering

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  • Dominique P. Pioletti

Abstract

Biomechanics may be considered as central in the development of bone tissue engineering. The initial mechanical aspects are essential to the outcome of a functional tissue engineering approach; so are aspects of interface micromotion, bone ingrowths inside the scaffold and finally, the mechanical integrity of the scaffold during its degradation. A proposed view is presented herein on how biomechanical aspects can be synthesised and where future developments are needed. In particular, a distinction is made between the mechanical and the mechanotransductional aspects of bone tissue engineering: the former could be related to osteoconduction, while the latter may be correlated to the osteoinductive properties of the scaffold. This distinction allows biomechanicians to follow a strategy in the development of a scaffold having not only mechanical targets but also incorporating some mechanotransduction principles.

Suggested Citation

  • Dominique P. Pioletti, 2010. "Biomechanics in bone tissue engineering," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 13(6), pages 837-846.
    • Handle: RePEc:taf:gcmbxx:v:13:y:2010:i:6:p:837-846
    DOI: 10.1080/10255841003630660
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    References listed on IDEAS

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    1. Alexandre Terrier & Marjan Sedighi-Gilani & Alireza Roshan Ghias & Line Aschwanden & Dominique P. Pioletti, 2009. "Biomechanical evaluation of porous biodegradable scaffolds for revision knee arthroplasty," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 12(3), pages 333-339.
    2. Rik Huiskes & Ronald Ruimerman & G. Harry van Lenthe & Jan D. Janssen, 2000. "Effects of mechanical forces on maintenance and adaptation of form in trabecular bone," Nature, Nature, vol. 405(6787), pages 704-706, June.
    3. Emma Brazel & David Taylor, 2009. "Predicting the structural integrity of bone defects repaired using bone graft materials," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 12(3), pages 297-304.
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    1. A. Roshan-Ghias & A. Terrier & B.M. Jolles & D.P. Pioletti, 2014. "Translation of biomechanical concepts in bone tissue engineering: from animal study to revision knee arthroplasty," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(8), pages 845-852, June.
    2. M. K. Heljak & K. J. Kurzydlowski & W. Swieszkowski, 2017. "Computer aided design of architecture of degradable tissue engineering scaffolds," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 20(15), pages 1623-1632, November.
    3. Dominique P. Pioletti, 2013. "Integration of mechanotransduction concepts in bone tissue engineering," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 16(10), pages 1050-1055, October.
    4. S. J. Ramos-Infante & M. A. Pérez, 2017. "and characterization of open-cell structures of trabecular bone," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 20(14), pages 1562-1570, October.

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