IDEAS home Printed from https://ideas.repec.org/a/taf/gcmbxx/v17y2014i8p845-852.html
   My bibliography  Save this article

Translation of biomechanical concepts in bone tissue engineering: from animal study to revision knee arthroplasty

Author

Listed:
  • A. Roshan-Ghias
  • A. Terrier
  • B.M. Jolles
  • D.P. Pioletti

Abstract

Bone defects in revision knee arthroplasty are often located in load-bearing regions. The goal of this study was to determine whether a physiologic load could be used as an in situ osteogenic signal to the scaffolds filling the bone defects. In order to answer this question, we proposed a novel translation procedure having four steps: (1) determining the mechanical stimulus using finite element method, (2) designing an animal study to measure bone formation spatially and temporally using micro-CT imaging in the scaffold subjected to the estimated mechanical stimulus, (3) identifying bone formation parameters for the loaded and non-loaded cases appearing in a recently developed mathematical model for bone formation in the scaffold and (4) estimating the stiffness and the bone formation in the bone-scaffold construct. With this procedure, we estimated that after 3 years mechanical stimulation increases the bone volume fraction and the stiffness of scaffold by 1.5- and 2.7-fold, respectively, compared to a non-loaded situation.

Suggested Citation

  • A. Roshan-Ghias & A. Terrier & B.M. Jolles & D.P. Pioletti, 2014. "Translation of biomechanical concepts in bone tissue engineering: from animal study to revision knee arthroplasty," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 17(8), pages 845-852, June.
    • Handle: RePEc:taf:gcmbxx:v:17:y:2014:i:8:p:845-852
    DOI: 10.1080/10255842.2012.719607
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/10255842.2012.719607
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/10255842.2012.719607?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Alexandre Terrier & Marjan Sedighi-Gilani & Alireza Roshan Ghias & Line Aschwanden & Dominique P. Pioletti, 2009. "Biomechanical evaluation of porous biodegradable scaffolds for revision knee arthroplasty," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 12(3), pages 333-339.
    2. Dominique P. Pioletti, 2010. "Biomechanics in bone tissue engineering," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 13(6), pages 837-846.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Dominique P. Pioletti, 2013. "Integration of mechanotransduction concepts in bone tissue engineering," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 16(10), pages 1050-1055, October.
    2. Dominique P. Pioletti, 2010. "Biomechanics in bone tissue engineering," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 13(6), pages 837-846.
    3. S. J. Ramos-Infante & M. A. Pérez, 2017. "and characterization of open-cell structures of trabecular bone," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 20(14), pages 1562-1570, October.
    4. M. K. Heljak & K. J. Kurzydlowski & W. Swieszkowski, 2017. "Computer aided design of architecture of degradable tissue engineering scaffolds," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 20(15), pages 1623-1632, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:gcmbxx:v:17:y:2014:i:8:p:845-852. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/gcmb .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.