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3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements

Author

Listed:
  • Vincent A. Stadelmann
  • Jean Hocké
  • Jensen Verhelle
  • Vincent Forster
  • Francesco Merlini
  • Alexandre Terrier
  • Dominique P. Pioletti

Abstract

A combined experimental/numerical study was performed to calculate the 3D octahedral shear strain map in a mouse tibia loaded axially. This study is motivated by the fact that the bone remodelling analysis, in this in vivo mouse model should be performed at the zone of highest mechanical stimulus to maximise the measured effects. Accordingly, it is proposed that quantification of bone remodelling should be performed at the tibial crest and at the distal diaphysis. The numerical model could also be used to furnish a more subtle analysis as a precise correlation between local strain and local biological response can be obtained with the experimentally validated numerical model.

Suggested Citation

  • Vincent A. Stadelmann & Jean Hocké & Jensen Verhelle & Vincent Forster & Francesco Merlini & Alexandre Terrier & Dominique P. Pioletti, 2009. "3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 12(1), pages 95-100.
  • Handle: RePEc:taf:gcmbxx:v:12:y:2009:i:1:p:95-100
    DOI: 10.1080/10255840802178053
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    References listed on IDEAS

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    1. Rik Huiskes & Ronald Ruimerman & G. Harry van Lenthe & Jan D. Janssen, 2000. "Effects of mechanical forces on maintenance and adaptation of form in trabecular bone," Nature, Nature, vol. 405(6787), pages 704-706, June.
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