IDEAS home Printed from https://ideas.repec.org/a/spr/stmapp/v15y2006i1p43-73.html
   My bibliography  Save this article

More Powerful Control of the False Discovery Rate Under Dependence

Author

Listed:
  • Alessio Farcomeni

    ()

Abstract

Abstract In a breakthrough paper, Benjamini and Hochberg (J Roy Stat Soc Ser B 57:289–300, 1995) proposed a new error measure for multiple testing, the FDR; and developed a distribution-free procedure to control it under independence among the test statistics. In this paper we argue by extensive simulation and theoretical considerations that the assumption of independence is not needed. Along the lines of (Ann Stat 32:1035–1061, 2004b), we moreover provide a more powerful method, that exploits an estimator of the number of false nulls among the tests. We propose a whole family of iterative estimators that prove robust under dependence and independence between the test statistics. These estimators can be used to improve also classical multiple testing procedures, and in general to estimate the weight of a known component in a mixture distribution. Innovations are illustrated by simulations.
(This abstract was borrowed from another version of this item.)

Suggested Citation

  • Alessio Farcomeni, 2006. "More Powerful Control of the False Discovery Rate Under Dependence," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 15(1), pages 43-73, May.
  • Handle: RePEc:spr:stmapp:v:15:y:2006:i:1:p:43-73
    DOI: 10.1007/s10260-006-0002-z
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1007/s10260-006-0002-z
    Download Restriction: Access to full text is restricted to subscribers.

    As the access to this document is restricted, you may want to look for a different version below or search for a different version of it.

    Other versions of this item:

    References listed on IDEAS

    as
    1. John D. Storey & Jonathan E. Taylor & David Siegmund, 2004. "Strong control, conservative point estimation and simultaneous conservative consistency of false discovery rates: a unified approach," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 66(1), pages 187-205.
    2. Efron B. & Tibshirani R. & Storey J.D. & Tusher V., 2001. "Empirical Bayes Analysis of a Microarray Experiment," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 1151-1160, December.
    3. Edward Ip, 2001. "Testing for local dependency in dichotomous and polytomous item response models," Psychometrika, Springer;The Psychometric Society, vol. 66(1), pages 109-132, March.
    4. John D. Storey, 2002. "A direct approach to false discovery rates," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 64(3), pages 479-498.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Farcomeni, Alessio & Pacillo, Simona, 2011. "A conservative estimator for the proportion of false nulls based on Dvoretzky, Kiefer and Wolfowitz inequality," Statistics & Probability Letters, Elsevier, vol. 81(12), pages 1867-1870.
    2. A. Farcomeni & L. Finos, 2013. "FDR Control with Pseudo-Gatekeeping Based on a Possibly Data Driven Order of the Hypotheses," Biometrics, The International Biometric Society, vol. 69(3), pages 606-613, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:stmapp:v:15:y:2006:i:1:p:43-73. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Sonal Shukla) or (Rebekah McClure). General contact details of provider: http://www.springer.com .

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service hosted by the Research Division of the Federal Reserve Bank of St. Louis . RePEc uses bibliographic data supplied by the respective publishers.