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Different Frameworks, Similar Results? Head-to-Head Comparison of the Generic Preference-Based Health-Outcome Measures CS-Base and EQ-5D-5L

Author

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  • Xin Zhang

    (University Medical Center Groningen)

  • Karin M. Vermeulen

    (University Medical Center Groningen)

  • Paul F. M. Krabbe

    (University Medical Center Groningen)

Abstract

Objective We compared two generic, preference-based health-outcome measures: the novel patient-centered Château-Santé Base (CS-Base), entailing a multi-attribute preference response framework, and the widely used EQ-5D-5L, regarding effects of different measurement frameworks and different descriptive systems. Methods We conducted a cross-sectional study using a random sample of patients (3019 reached, 1988 included) in the USA with various health conditions. The CS-Base (12 attributes, each with four levels), EQ-5D-5L and the 5D-4L (an ad hoc, multi-attribute preference response-based measure that includes five attributes similar to the EQ-5D-5L, but with four levels) were used as health-outcome measures. We compared the proportions of problems reported on health attributes, statistical robustness and face validity of coefficients, attribute importance, differentiation between health states based on health-state values obtained with these measures, and user experience. Results All the CS-Base and 5D-4L coefficients had logical orders and significant differences from the reference level (p

Suggested Citation

  • Xin Zhang & Karin M. Vermeulen & Paul F. M. Krabbe, 2024. "Different Frameworks, Similar Results? Head-to-Head Comparison of the Generic Preference-Based Health-Outcome Measures CS-Base and EQ-5D-5L," Applied Health Economics and Health Policy, Springer, vol. 22(2), pages 227-242, March.
    • Handle: RePEc:spr:aphecp:v:22:y:2024:i:2:d:10.1007_s40258-023-00837-1
    DOI: 10.1007/s40258-023-00837-1
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    1. Angela Robinson & Anne Spencer, 2006. "Exploring challenges to TTO utilities: valuing states worse than dead," Health Economics, John Wiley & Sons, Ltd., vol. 15(4), pages 393-402, April.
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