IDEAS home Printed from https://ideas.repec.org/a/sae/medema/v32y2012i1p70-82.html
   My bibliography  Save this article

Effect of Treatment Interruption and Intensification of Antiretroviral Therapy on Health-Related Quality of Life in Patients with Advanced HIV

Author

Listed:
  • Vilija R. Joyce
  • Paul G. Barnett
  • Adam Chow
  • Ahmed M. Bayoumi
  • Susan C. Griffin
  • Huiying Sun
  • Mark Holodniy
  • Sheldon T. Brown
  • Tassos C. Kyriakides
  • D. William Cameron
  • Mike Youle
  • Mark Sculpher
  • Aslam H. Anis
  • Douglas K. Owens

Abstract

Background . The effect of antiretroviral therapy (ART) interruption or intensification on health-related quality of life (HRQoL) in advanced HIV patients is unknown. Objective . To assess the impact of temporary treatment interruption and intensification of ART on HRQoL. Design . A 2 x 2 factorial open label randomized controlled trial. Setting . Hospitals in the United States, Canada, and the United Kingdom. Patients . Multidrug resistant (MDR) HIV patients. Intervention . Patients were randomized to receive a 12-wk interruption or not, and ART intensification or standard ART. Measurements . The Health Utilities Index (HUI3), EQ-5D, standard gamble (SG), time tradeoff (TTO), visual analog scale (VAS), and the Medical Outcomes Study HIV Health Survey (MOS-HIV). Results . There were no significant differences in HRQoL among the four groups during follow-up; however, there was a temporary significant decline in HRQoL on some measures within the interruption group during interruption (HUI3 −0.05, P = 0.03; VAS −5.9, P = 0.002; physical health summary −2.9, P = 0.001; mental health summary −1.9, P = 0.02). Scores declined slightly overall during follow-up. Multivariate analysis showed significantly lower HRQoL associated with some clinical events. Limitations . The results may not apply to HIV patients who have not experienced multiple treatment failures or who have not developed MDR HIV. Conclusions . Temporary ART interruption and ART intensification provided neither superior nor inferior HRQoL compared with no interruption and standard ART. Among surviving patients, HRQoL scores declined only slightly over years of follow-up in this advanced HIV cohort; however, approximately one-third of patients died during the trial follow up. Lower HRQoL was associated with adverse clinical events.

Suggested Citation

  • Vilija R. Joyce & Paul G. Barnett & Adam Chow & Ahmed M. Bayoumi & Susan C. Griffin & Huiying Sun & Mark Holodniy & Sheldon T. Brown & Tassos C. Kyriakides & D. William Cameron & Mike Youle & Mark Scu, 2012. "Effect of Treatment Interruption and Intensification of Antiretroviral Therapy on Health-Related Quality of Life in Patients with Advanced HIV," Medical Decision Making, , vol. 32(1), pages 70-82, January.
    • Handle: RePEc:sae:medema:v:32:y:2012:i:1:p:70-82
    DOI: 10.1177/0272989X10397615
    as

    Download full text from publisher

    File URL: https://journals.sagepub.com/doi/10.1177/0272989X10397615
    Download Restriction: no
    File URL: https://libkey.io/10.1177/0272989X10397615?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Feeny, David & Furlong, William & Saigal, Saroj & Sun, Jian, 2004. "Comparing directly measured standard gamble scores to HUI2 and HUI3 utility scores: group- and individual-level comparisons," Social Science & Medicine, Elsevier, vol. 58(4), pages 799-809, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Huguet, Nathalie & Kaplan, Mark S. & Feeny, David, 2008. "Socioeconomic status and health-related quality of life among elderly people: Results from the Joint Canada/United States Survey of Health," Social Science & Medicine, Elsevier, vol. 66(4), pages 803-810, February.
    2. Asakawa, Keiko & Feeny, David & Senthilselvan, Ambikaipakan & Johnson, Jeffrey A. & Rolfson, Darryl, 2009. "Do the determinants of health differ between people living in the community and in institutions?," Social Science & Medicine, Elsevier, vol. 69(3), pages 345-353, August.
    3. Musal, R. Muzaffer & Soyer, Refik & McCabe, Christopher & Kharroubi, Samer A., 2012. "Estimating the population utility function: A parametric Bayesian approach," European Journal of Operational Research, Elsevier, vol. 218(2), pages 538-547.
    4. Rachel Lee-Yin Tan & Sonia Zhi Yi Soh & Le Ann Chen & Michael Herdman & Nan Luo, 2023. "Psychometric Properties of Generic Preference-Weighted Measures for Children and Adolescents: A Systematic Review," PharmacoEconomics, Springer, vol. 41(2), pages 155-174, February.
    5. J. Tilford & Nalin Payakachat & Erica Kovacs & Jeffrey Pyne & Werner Brouwer & Todd Nick & Jayne Bellando & Karen Kuhlthau, 2012. "Preference-Based Health-Related Quality-of-Life Outcomes in Children with Autism Spectrum Disorders," PharmacoEconomics, Springer, vol. 30(8), pages 661-679, August.
    6. Stavros Petrou & Natnaree Krabuanrat & Kamran Khan, 2020. "Preference-Based Health-Related Quality of Life Outcomes Associated with Preterm Birth: A Systematic Review and Meta-analysis," PharmacoEconomics, Springer, vol. 38(4), pages 357-373, April.
    7. Christine McDonough & Anna Tosteson, 2007. "Measuring Preferences for Cost-Utility Analysis," PharmacoEconomics, Springer, vol. 25(2), pages 93-106, February.
    8. Gang Chen & Julie Ratcliffe, 2015. "A Review of the Development and Application of Generic Multi-Attribute Utility Instruments for Paediatric Populations," PharmacoEconomics, Springer, vol. 33(10), pages 1013-1028, October.
    9. Gillian A. Lancaster, 2009. "Statistical issues in the assessment of health outcomes in children: a methodological review," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 172(4), pages 707-727, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:sae:medema:v:32:y:2012:i:1:p:70-82. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: SAGE Publications (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.