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The efficacy of inspiratory muscle training in patients with coronary artery disease: Protocol for a systematic review and meta-analysis

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  • Yoshito Kadoya
  • Saad Balamane
  • Sarah Visintini
  • Benjamin Chow

Abstract

Background: Inspiratory muscle training (IMT) has been recognized as an effective form of training in patients with cardiovascular disease and heart failure. However, little is known about the efficacy of IMT in the treatment of patients with coronary artery disease (CAD). The aim of this systematic review will be to evaluate randomized controlled studies to understand the effect of IMT on CAD patients. Method: We will include randomized controlled trials evaluating the efficacy of IMT in patients 18 years and older diagnosed with CAD. Crossover trials, cluster-randomized, quasi-randomized, and non-randomized trials will be excluded. Study search will be conducted in major databases (MEDLINE, the Cochrane Central Register of Controlled Trials, Embase, and PEDro). The study intervention will be IMT independent of the duration, frequency, or intensity of training. The primary outcome will be quality of life, patient-reported health status, and all adverse events related to IMT. Secondary outcomes will include exercise capacity and respiratory muscle strength. The risk of bias will be evaluated based on the Cochrane Risk of Bias tool. Screening, data extraction, and quality assessment will be performed by two independent reviewers. If two or more studies are considered to be clinically homogeneous, a meta-analysis based on the random-effects model will be performed. The quality of evidence will be evaluated based on the GRADE approach. Conclusion: This systematic review will improve our understanding of the effects of IMT on CAD patients and potentially establish IMT as an alternative form of exercise training for the treatment of CAD. Trial registration: Study registration. OSF registries (https://osf.io/3ch7m). Date registered: May 10, 2022. Registration DOI: https://doi.org/10.17605/OSF.IO/GVMY7.

Suggested Citation

  • Yoshito Kadoya & Saad Balamane & Sarah Visintini & Benjamin Chow, 2023. "The efficacy of inspiratory muscle training in patients with coronary artery disease: Protocol for a systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(9), pages 1-8, September.
    • Handle: RePEc:plo:pone00:0289287
    DOI: 10.1371/journal.pone.0289287
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    1. Sarah Kelly & Steven Martin & Isla Kuhn & Andy Cowan & Carol Brayne & Louise Lafortune, 2016. "Barriers and Facilitators to the Uptake and Maintenance of Healthy Behaviours by People at Mid-Life: A Rapid Systematic Review," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-26, January.
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