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Association between early serum cholinesterase activity and 30-day mortality in sepsis-3 patients: A retrospective cohort study

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  • Zheng-Liang Peng
  • Liang-Wei Huang
  • Jian Yin
  • Ke-Na Zhang
  • Kang Xiao
  • Guo-Zhong Qing

Abstract

Low serum cholinesterase (SCHE) activity has been associated with poor prognoses in a variety of conditions, including sepsis. However, such an association has not been well characterized since the Third International Consensus Definitions Task Force modified the definition of sepsis to “life-threatening organ dysfunction due to a dysregulated host response to infection” (known as sepsis-3) in 2016. In the current retrospective cohort study, we examined whether 30-day mortality in sepsis-3 patients is associated with SCHE activity. A total of 166 sepsis-3 patients receiving treatment at an emergency intensive care unit (EICU) were included. The 30-day death rate was 33.1% (55/166). SCHE activity upon EICU admission was lower in nonsurvivors (3.3 vs. 4.5 KU/L in survivors, p = 0.0002). Subjects with low SCHE activity (defined as

Suggested Citation

  • Zheng-Liang Peng & Liang-Wei Huang & Jian Yin & Ke-Na Zhang & Kang Xiao & Guo-Zhong Qing, 2018. "Association between early serum cholinesterase activity and 30-day mortality in sepsis-3 patients: A retrospective cohort study," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0203128
    DOI: 10.1371/journal.pone.0203128
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