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Long Term Evaluation of the Impact of Autologous Peripheral Blood Stem Cell Transplantation in Multiple Myeloma: A Cost-Effectiveness Analysis

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  • Alessandro Corso
  • Silvia Mangiacavalli
  • Federica Cocito
  • Cristiana Pascutto
  • Virginia Valeria Ferretti
  • Alessandra Pompa
  • Roberta Ciampichini
  • Lara Pochintesta
  • Lorenzo G Mantovani

Abstract

Background: High-dose therapy with autologous peripheral stem cell transplantation represents today the standard approach for younger multiple myeloma patients. This study aimed to evaluate the long term economic impact of autologous transplantation with respect to conventional therapy. Methods: We retrospectively reviewed the charts of multiple myeloma patients diagnosed at our department between 1986 and 2003 and treated according to the therapy considered standard at the time of diagnosis. Analysis of costs was done by assessing resource utilization and direct costs were measured and monetized before proceeding with the analysis, based on public health service tariffs. Results: Group A including 78 patients treated with Melphalan and Prednisone was compared with Group B including 74 patients who received an autologous transplant. The median overall survival was 3.2 and 5.4 years respectively (p = 0.0002). Mean cost per patient was significantly higher in group B with respect to group A (102373€ vs 23825€; p

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  • Alessandro Corso & Silvia Mangiacavalli & Federica Cocito & Cristiana Pascutto & Virginia Valeria Ferretti & Alessandra Pompa & Roberta Ciampichini & Lara Pochintesta & Lorenzo G Mantovani, 2013. "Long Term Evaluation of the Impact of Autologous Peripheral Blood Stem Cell Transplantation in Multiple Myeloma: A Cost-Effectiveness Analysis," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-6, September.
    • Handle: RePEc:plo:pone00:0075047
    DOI: 10.1371/journal.pone.0075047
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    1. Nord, Erik, 1992. "Methods for quality adjustment of life years," Social Science & Medicine, Elsevier, vol. 34(5), pages 559-569, March.
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    1. Jason R. Guertin & Blanchard Conombo & Raphaël Langevin & Frédéric Bergeron & Anne Holbrook & Brittany Humphries & Alexis Matteau & Brian J. Potter & Christel Renoux & Jean-Éric Tarride & Madelein, 2020. "A Systematic Review of Methods Used for Confounding Adjustment in Observational Economic Evaluations in Cardiology Conducted between 2013 and 2017," Medical Decision Making, , vol. 40(5), pages 582-595, July.

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