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CYP11B2 T-344C Gene Polymorphism and Atrial Fibrillation: A Meta-Analysis of 2,758 Subjects

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  • Yan-yan Li
  • Chuan-wei Zhou
  • Jian Xu
  • Yun Qian
  • Bei Wang

Abstract

Background: Aldosterone synthase (CYP11B2) T-344C gene polymorphism was found to be correlated with atrial fibrillation (AF) risk. However, the results of individual studies remain conflicting. Objective and methods: A meta-analysis including 2,758 subjects from six individual studies was performed to explore the correlation between CYP11B2 T-344C gene polymorphisms and AF. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by the fixed– or random–effects model. Results: A significant relationship between CYP11B2 T-344C gene polymorphism and AF was found under allelic (OR: 1.26, 95% CI: 1.11–1.42, P = 0.0002), recessive (OR: 1.99, 95% CI: 1.26–3.14, P = 0.003), dominant (OR: 0.903, 95% CI: 0.820–0.994, P = 0.036), homozygous (OR: 1.356, 95% CI: 1.130–1.628, P = 0.001), and additive (OR: 1.153, 95% CI: 1.070–1.243, P = 1.0×10−10) genetic models. No significant association between CYP11B2 T-344C gene polymorphism and AF was found under the heterozygous genetic model (OR: 1.040, 95% CI: 0.956–1.131, P = 0.361). Conclusions: A significant association was found between CYP11B2 T-344C gene polymorphism and AF risk. Individuals with the C allele of CYP11B2 T-344C gene polymorphism have higher risk for AF.

Suggested Citation

  • Yan-yan Li & Chuan-wei Zhou & Jian Xu & Yun Qian & Bei Wang, 2012. "CYP11B2 T-344C Gene Polymorphism and Atrial Fibrillation: A Meta-Analysis of 2,758 Subjects," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-7, November.
    • Handle: RePEc:plo:pone00:0050910
    DOI: 10.1371/journal.pone.0050910
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    References listed on IDEAS

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    1. Stanley Nattel, 2002. "New ideas about atrial fibrillation 50 years on," Nature, Nature, vol. 415(6868), pages 219-226, January.
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    Cited by:

    1. Yan Pi & Li-li Zhang & Kai Chang & Lu Guo & Yun Liu & Bing-hu Li & Xiao-jie Cao & Shao-qiong Liao & Chang-yue Gao & Jing-cheng Li, 2013. "Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-7, August.
    2. Wu, Mengjia & Zhang, Yi & Zhang, Guangquan & Lu, Jie, 2021. "Exploring the genetic basis of diseases through a heterogeneous bibliometric network: A methodology and case study," Technological Forecasting and Social Change, Elsevier, vol. 164(C).

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