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Support of Unrelated Stem Cell Donor Searches by Donor Center-Initiated HLA Typing of Potentially Matching Donors

Author

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  • Alexander H Schmidt
  • Ute V Solloch
  • Daniel Baier
  • Alois Grathwohl
  • Jan Hofmann
  • Julia Pingel
  • Andrea Stahr
  • Gerhard Ehninger

Abstract

Large registries of potential unrelated stem cell donors have been established in order to enable stem cell transplantation for patients without HLA-identical related donors. Donor search is complicated by the fact that the stored HLA information of many registered donors is incomplete. We carried out a project that was aimed to improve chances of patients with ongoing donor searches to find an HLA-matched unrelated donor. For that purpose, we carried out additional donor center-initiated HLA-DRB1 typing of donors who were only typed for the HLA loci A and B so far and were potential matches for patients in need of a stem cell transplant. In total, 8,861 donors were contacted for donor center-initiated HLA-DRB1 typing within 1,089 donor searches. 12 of these donors have donated stem cells so far, 8 thereof for their respective target patients. We conclude that chances of patients with ongoing donor searches to find an HLA-matched unrelated donor can indeed be improved by donor-center initiated typing that is carried out in addition to the standard donor search process. Our results also raise questions regarding the appropriate use of incompletely typed donors within unrelated donor searches.

Suggested Citation

  • Alexander H Schmidt & Ute V Solloch & Daniel Baier & Alois Grathwohl & Jan Hofmann & Julia Pingel & Andrea Stahr & Gerhard Ehninger, 2011. "Support of Unrelated Stem Cell Donor Searches by Donor Center-Initiated HLA Typing of Potentially Matching Donors," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-5, May.
    • Handle: RePEc:plo:pone00:0020268
    DOI: 10.1371/journal.pone.0020268
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    Cited by:

    1. Michael Haylock & Patrick Kampkötter & Mario Macis & Jürgen Sauter & Susanne Seitz & Robert Slonim & Daniel Wiesen & Alexander H. Schmidt, 2022. "Improving the Availability of Unrelated Stem Cell Donors: Evidence from a Major Donor Registry," NBER Working Papers 29857, National Bureau of Economic Research, Inc.

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