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Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues

Author

Listed:
  • Heather E Wheeler
  • Kaanan P Shah
  • Jonathon Brenner
  • Tzintzuni Garcia
  • Keston Aquino-Michaels
  • GTEx Consortium
  • Nancy J Cox
  • Dan L Nicolae
  • Hae Kyung Im

Abstract

Understanding the genetic architecture of gene expression traits is key to elucidating the underlying mechanisms of complex traits. Here, for the first time, we perform a systematic survey of the heritability and the distribution of effect sizes across all representative tissues in the human body. We find that local h2 can be relatively well characterized with 59% of expressed genes showing significant h2 (FDR

Suggested Citation

  • Heather E Wheeler & Kaanan P Shah & Jonathon Brenner & Tzintzuni Garcia & Keston Aquino-Michaels & GTEx Consortium & Nancy J Cox & Dan L Nicolae & Hae Kyung Im, 2016. "Survey of the Heritability and Sparse Architecture of Gene Expression Traits across Human Tissues," PLOS Genetics, Public Library of Science, vol. 12(11), pages 1-23, November.
    • Handle: RePEc:plo:pgen00:1006423
    DOI: 10.1371/journal.pgen.1006423
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    References listed on IDEAS

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    Cited by:

    1. Satoko Namba & Michio Iwata & Shin-Ichi Nureki & Noriko Yuyama Otani & Yoshihiro Yamanishi, 2025. "Therapeutic target prediction for orphan diseases integrating genome-wide and transcriptome-wide association studies," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    2. Thomas Battram & Tom R. Gaunt & Caroline L. Relton & Nicholas J. Timpson & Gibran Hemani, 2022. "A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Kevin L Keys & Angel C Y Mak & Marquitta J White & Walter L Eckalbar & Andrew W Dahl & Joel Mefford & Anna V Mikhaylova & María G Contreras & Jennifer R Elhawary & Celeste Eng & Donglei Hu & Scott Hun, 2020. "On the cross-population generalizability of gene expression prediction models," PLOS Genetics, Public Library of Science, vol. 16(8), pages 1-28, August.
    4. Mike Thompson & Mary Grace Gordon & Andrew Lu & Anchit Tandon & Eran Halperin & Alexander Gusev & Chun Jimmie Ye & Brunilda Balliu & Noah Zaitlen, 2022. "Multi-context genetic modeling of transcriptional regulation resolves novel disease loci," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. repec:plo:pone00:0220827 is not listed on IDEAS

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