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Evolution of Robustness and Cellular Stochasticity of Gene Expression

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  • Steven A Frank

Abstract

Recent measurements of gene expression show a lot of randomness between cells. Steven Frank proposes a theory in which robustness protects against the effects of randomness and so allows relaxed regulatory control and greater randomness to evolve.Gene expression varies widely in cells with the same genotype and environment [1],[2]. Predicting the patterns of stochastic cellular fluctuations remains an unsolved challenge. I propose that the degree to which varying cellular components combine to determine robust phenotypes may predict the amount of variability. Microbes provide excellent experimental models to analyze the relations between robust phenotypes and stochastic variability.

Suggested Citation

  • Steven A Frank, 2013. "Evolution of Robustness and Cellular Stochasticity of Gene Expression," PLOS Biology, Public Library of Science, vol. 11(6), pages 1-3, June.
    • Handle: RePEc:plo:pbio00:1001578
    DOI: 10.1371/journal.pbio.1001578
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    References listed on IDEAS

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    1. Alex Sigal & Ron Milo & Ariel Cohen & Naama Geva-Zatorsky & Yael Klein & Yuvalal Liron & Nitzan Rosenfeld & Tamar Danon & Natalie Perzov & Uri Alon, 2006. "Variability and memory of protein levels in human cells," Nature, Nature, vol. 444(7119), pages 643-646, November.
    2. Steven A Frank, 2007. "Maladaptation and the Paradox of Robustness in Evolution," PLOS ONE, Public Library of Science, vol. 2(10), pages 1-6, October.
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