IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v408y2000i6810d10.1038_35042675.html
   My bibliography  Save this article

Surfing the p53 network

Author

Listed:
  • Bert Vogelstein

    (The Howard Hughes Medical Institute and Johns Hopkins Oncology Center)

  • David Lane

    (Ninewells Hospital, University of Dundee)

  • Arnold J. Levine

    (Laboratory of Cancer Biology, Genetics, and Molecular Biophysics, Rockefeller University)

Abstract

The p53 tumour-suppressor gene integrates numerous signals that control cell life and death. As when a highly connected node in the Internet breaks down, the disruption of p53 has severe consequences.

Suggested Citation

  • Bert Vogelstein & David Lane & Arnold J. Levine, 2000. "Surfing the p53 network," Nature, Nature, vol. 408(6810), pages 307-310, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6810:d:10.1038_35042675
    DOI: 10.1038/35042675
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35042675
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35042675?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Bálint Mészáros & István Simon & Zsuzsanna Dosztányi, 2009. "Prediction of Protein Binding Regions in Disordered Proteins," PLOS Computational Biology, Public Library of Science, vol. 5(5), pages 1-18, May.
    2. Jae Kyoung Kim & Trachette L Jackson, 2013. "Mechanisms That Enhance Sustainability of p53 Pulses," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-11, June.
    3. Ikeda, N., 2007. "Network formed by traces of random walks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 379(2), pages 701-713.
    4. Jeffrey V Wong & Bochong Li & Lingchong You, 2012. "Tension and Robustness in Multitasking Cellular Networks," PLOS Computational Biology, Public Library of Science, vol. 8(4), pages 1-12, April.
    5. Ronja Foraita & Juliane Friemel & Kathrin Günther & Thomas Behrens & Jörn Bullerdiek & Rolf Nimzyk & Wolfgang Ahrens & Vanessa Didelez, 2020. "Causal discovery of gene regulation with incomplete data," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 183(4), pages 1747-1775, October.
    6. Wassim Abou-Jaoudé & Madalena Chaves & Jean-Luc Gouzé, 2011. "A Theoretical Exploration of Birhythmicity in the p53-Mdm2 Network," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-12, February.
    7. Phillips, J.C., 2016. "Autoantibody recognition mechanisms of p53 epitopes," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 451(C), pages 162-170.
    8. Shruti Koulgi & Archana Achalere & Uddhavesh Sonavane & Rajendra Joshi, 2015. "Investigating DNA Binding and Conformational Variation in Temperature Sensitive p53 Cancer Mutants Using QM-MM Simulations," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-22, November.
    9. Sirkku Karinen & Tuomas Heikkinen & Heli Nevanlinna & Sampsa Hautaniemi, 2011. "Data Integration Workflow for Search of Disease Driving Genes and Genetic Variants," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-8, April.
    10. Piotrowska, Monika J. & Bartłomiejczyk, Agnieszka & Bodnar, Marek, 2018. "Mathematical analysis of a generalised p53-Mdm2 protein gene expression model," Applied Mathematics and Computation, Elsevier, vol. 328(C), pages 26-44.
    11. Yong-Jun Shin & Ali H Sayed & Xiling Shen, 2012. "Adaptive Models for Gene Networks," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-6, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:408:y:2000:i:6810:d:10.1038_35042675. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.